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Article: Pre-pandemic live-attenuated influenza vaccine

TitlePre-pandemic live-attenuated influenza vaccine
Authors
Issue Date2019
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
Hong Kong Medical Journal, 2019, v. 25 n. suppl. 9, p. 24-27 How to Cite?
AbstractKEY MESSAGES 1. During the 2009 influenza pandemic in Hong Kong, matched vaccines for the pandemic strain were not available until 8 months after its start. We described the potential use of pre-pandemic seasonal vaccine to mitigate the next pandemic. 2. We used an age-structured epidemic model to identify the optimal timing and age-specific allocation strategies for administration of vaccinations. 3. With a stockpile of 200 000 doses, if we start vaccinating those aged 5 to 9 years and 15 to 19 years on day 1, the maximum peak time delayed is 17.4 days and the peak height reduction is 16.8%, compared with no vaccination. 4. If we start vaccinating on 98.8th day, the maximum reduction in death is 13.85% by vaccinating those aged 5 to 9 years and 15 to 19 years. The maximum reduction in hospitalisation is 15.00% by vaccinating those aged 5 to 19 years. 5. In future influenza pandemic with limited vaccine stockpile, vaccinating those aged 5 to 19 years one week before the major wave can minimise the number of hospitalisations and deaths. Vaccination campaign should be started early in order to delay the arrival of a major wave of infections and reduce its height.
Persistent Identifierhttp://hdl.handle.net/10722/281765
ISSN
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 0.261
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHe, DH-
dc.contributor.authorChiu, APY-
dc.contributor.authorWu, JTK-
dc.contributor.authorCowling, BJ-
dc.date.accessioned2020-03-27T04:22:17Z-
dc.date.available2020-03-27T04:22:17Z-
dc.date.issued2019-
dc.identifier.citationHong Kong Medical Journal, 2019, v. 25 n. suppl. 9, p. 24-27-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/281765-
dc.description.abstractKEY MESSAGES 1. During the 2009 influenza pandemic in Hong Kong, matched vaccines for the pandemic strain were not available until 8 months after its start. We described the potential use of pre-pandemic seasonal vaccine to mitigate the next pandemic. 2. We used an age-structured epidemic model to identify the optimal timing and age-specific allocation strategies for administration of vaccinations. 3. With a stockpile of 200 000 doses, if we start vaccinating those aged 5 to 9 years and 15 to 19 years on day 1, the maximum peak time delayed is 17.4 days and the peak height reduction is 16.8%, compared with no vaccination. 4. If we start vaccinating on 98.8th day, the maximum reduction in death is 13.85% by vaccinating those aged 5 to 9 years and 15 to 19 years. The maximum reduction in hospitalisation is 15.00% by vaccinating those aged 5 to 19 years. 5. In future influenza pandemic with limited vaccine stockpile, vaccinating those aged 5 to 19 years one week before the major wave can minimise the number of hospitalisations and deaths. Vaccination campaign should be started early in order to delay the arrival of a major wave of infections and reduce its height.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.titlePre-pandemic live-attenuated influenza vaccine-
dc.typeArticle-
dc.identifier.emailWu, JTK: joewu@hku.hk-
dc.identifier.authorityWu, JTK=rp00517-
dc.description.naturepublished_or_final_version-
dc.identifier.pmid31889031-
dc.identifier.scopuseid_2-s2.0-85077320748-
dc.identifier.hkuros309575-
dc.identifier.volume25-
dc.identifier.issuesuppl. 9-
dc.identifier.spage24-
dc.identifier.epage27-
dc.identifier.isiWOS:000688287700007-
dc.publisher.placeHong Kong-
dc.identifier.issnl1024-2708-

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