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- Publisher Website: 10.1093/ije/dyz238
- Scopus: eid_2-s2.0-85078129383
- PMID: 31872233
- WOS: WOS:000542052400010
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Article: Determinants of physical, mental and social well-being: a longitudinal environment-wide association study
Title | Determinants of physical, mental and social well-being: a longitudinal environment-wide association study |
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Authors | |
Keywords | Environment-wide association study physical well-being mental well-being social well-being depressive symptoms |
Issue Date | 2020 |
Publisher | Oxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/ |
Citation | International Journal of Epidemiology, 2020, v. 49 n. 2, p. 380-389 How to Cite? |
Abstract | Background
Although the World Health Organization (WHO) has defined health as a state of physical, mental and social well-being, public health strategies have primarily focused on one domain of well-being. We sought to systematically and simultaneously identify and validate associations of behavioural patterns, psychosocial factors, mental and physical health conditions, access to and utilization of health care and anthropometrics with physical, mental and social well-being.
Methods:
We conducted a longitudinal environment-wide association study (EWAS) with a training and testing set approach, accounting for multiple testing using a false discovery rate control. We used multivariate multilevel regression to examine the association of each exposure at wave 1 with the three outcomes at wave 2 in the Hong Kong FAMILY Cohort (n = 10 484).
Results:
Out of 194 exposures, we identified and validated 14, 5 and 5 exposures that were individually associated with physical, mental and social well-being, respectively. We discovered three factors, namely depressive symptoms, life satisfaction and happiness, that were simultaneously associated with the three domains that define health.
Conclusions:
These associations, if verified to be causal, could become intervention targets to holistically improve population health. Our findings provide empirical support for placing mental health at the forefront of the public health agenda, and also support recent calls to use life satisfaction and happiness to guide public policy. |
Persistent Identifier | http://hdl.handle.net/10722/281669 |
ISSN | 2021 Impact Factor: 9.685 2020 SCImago Journal Rankings: 3.406 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ni, MY | - |
dc.contributor.author | Yao, X | - |
dc.contributor.author | Cheung, F | - |
dc.contributor.author | Wu, JT | - |
dc.contributor.author | Schooling, CM | - |
dc.contributor.author | Pang, H | - |
dc.contributor.author | Leung, GM | - |
dc.date.accessioned | 2020-03-22T04:18:03Z | - |
dc.date.available | 2020-03-22T04:18:03Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | International Journal of Epidemiology, 2020, v. 49 n. 2, p. 380-389 | - |
dc.identifier.issn | 0300-5771 | - |
dc.identifier.uri | http://hdl.handle.net/10722/281669 | - |
dc.description.abstract | Background Although the World Health Organization (WHO) has defined health as a state of physical, mental and social well-being, public health strategies have primarily focused on one domain of well-being. We sought to systematically and simultaneously identify and validate associations of behavioural patterns, psychosocial factors, mental and physical health conditions, access to and utilization of health care and anthropometrics with physical, mental and social well-being. Methods: We conducted a longitudinal environment-wide association study (EWAS) with a training and testing set approach, accounting for multiple testing using a false discovery rate control. We used multivariate multilevel regression to examine the association of each exposure at wave 1 with the three outcomes at wave 2 in the Hong Kong FAMILY Cohort (n = 10 484). Results: Out of 194 exposures, we identified and validated 14, 5 and 5 exposures that were individually associated with physical, mental and social well-being, respectively. We discovered three factors, namely depressive symptoms, life satisfaction and happiness, that were simultaneously associated with the three domains that define health. Conclusions: These associations, if verified to be causal, could become intervention targets to holistically improve population health. Our findings provide empirical support for placing mental health at the forefront of the public health agenda, and also support recent calls to use life satisfaction and happiness to guide public policy. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/ | - |
dc.relation.ispartof | International Journal of Epidemiology | - |
dc.rights | Pre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here]. | - |
dc.subject | Environment-wide association study | - |
dc.subject | physical well-being | - |
dc.subject | mental well-being | - |
dc.subject | social well-being | - |
dc.subject | depressive symptoms | - |
dc.title | Determinants of physical, mental and social well-being: a longitudinal environment-wide association study | - |
dc.type | Article | - |
dc.identifier.email | Ni, MY: nimy@hku.hk | - |
dc.identifier.email | Yao, X: irisyxx@hku.hk | - |
dc.identifier.email | Cheung, F: felixckc@hku.hk | - |
dc.identifier.email | Wu, JT: joewu@hku.hk | - |
dc.identifier.email | Schooling, CM: cms1@hkucc.hku.hk | - |
dc.identifier.email | Pang, H: herbpang@hku.hk | - |
dc.identifier.email | Leung, GM: gmleung@hku.hk | - |
dc.identifier.authority | Ni, MY=rp01639 | - |
dc.identifier.authority | Cheung, F=rp02275 | - |
dc.identifier.authority | Wu, JT=rp00517 | - |
dc.identifier.authority | Schooling, CM=rp00504 | - |
dc.identifier.authority | Pang, H=rp01857 | - |
dc.identifier.authority | Leung, GM=rp00460 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1093/ije/dyz238 | - |
dc.identifier.pmid | 31872233 | - |
dc.identifier.scopus | eid_2-s2.0-85078129383 | - |
dc.identifier.hkuros | 309483 | - |
dc.identifier.volume | 49 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 380 | - |
dc.identifier.epage | 389 | - |
dc.identifier.isi | WOS:000542052400010 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0300-5771 | - |