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Article: Fine particulate matter and cause-specific mortality in the Hong Kong elder patients with chronic kidney disease

TitleFine particulate matter and cause-specific mortality in the Hong Kong elder patients with chronic kidney disease
Authors
KeywordsFine particulate matter
Chronic kidney disease
Ischemic heart disease
Cohort study
Issue Date2020
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/chemosphere
Citation
Chemosphere, 2020, v. 247, p. article no. 125913 How to Cite?
AbstractEmerging epidemiologic studies suggested that particulate matter (PM) was a risk factor for the incidence of chronic kidney disease (CKD). However, few studies were conducted to examine whether PM was associated with cause-specific deaths in the CKD progression. This study aimed to estimate the association between fine particulate matter (PM2.5) and a spectrum of deaths among CKD patients. We took leverage of the Elderly Health Service cohort (n = 66,820), a large Hong Kong elderly cohort followed up till 2010. A total of 902 CKD incident patients in the cohort were identified during the follow-up period. We estimated yearly PM2.5 at the residential address for each CKD patient based on a satellite-based spatiotemporal model. We used Cox proportional hazards models with attained age as the underlying timescale to assess the association between long-term exposure to PM2.5 and cause-specific mortality among CKD patients. A total of 496 patients died during the follow-up, where 147 died from cardiovascular disease, 61 from respiratory disease and 154 from renal failure. The mortality hazard ratio (HR) per interquartile-range increase in PM2.5 (4.0 μg/m3) was 1.97 (95% confidence interval (CI): 1.34 to 2.91) for ischemic heart disease (IHD) among CKD patients, and was 1.42 (95%CI: 1.05 to 1.93) for CKD among those patients concomitantly with hypertension. Associations were not of statistical significance between PM2.5 and mortality hazard ratios of all-cause, stroke, and pneumonia among CKD patients. Our findings suggest that long-term exposure to PM2.5 may contribute to the CKD progression into ischemic heart diseases.
Persistent Identifierhttp://hdl.handle.net/10722/281661
ISSN
2019 Impact Factor: 5.778
2015 SCImago Journal Rankings: 1.536

 

DC FieldValueLanguage
dc.contributor.authorRAN, J-
dc.contributor.authorSUN, S-
dc.contributor.authorHan, L-
dc.contributor.authorZhao, S-
dc.contributor.authorChen, D-
dc.contributor.authorGUO, F-
dc.contributor.authorLi, JC-
dc.contributor.authorQiu, H-
dc.contributor.authorLei, Y-
dc.contributor.authorTian, L-
dc.date.accessioned2020-03-22T04:17:56Z-
dc.date.available2020-03-22T04:17:56Z-
dc.date.issued2020-
dc.identifier.citationChemosphere, 2020, v. 247, p. article no. 125913-
dc.identifier.issn0045-6535-
dc.identifier.urihttp://hdl.handle.net/10722/281661-
dc.description.abstractEmerging epidemiologic studies suggested that particulate matter (PM) was a risk factor for the incidence of chronic kidney disease (CKD). However, few studies were conducted to examine whether PM was associated with cause-specific deaths in the CKD progression. This study aimed to estimate the association between fine particulate matter (PM2.5) and a spectrum of deaths among CKD patients. We took leverage of the Elderly Health Service cohort (n = 66,820), a large Hong Kong elderly cohort followed up till 2010. A total of 902 CKD incident patients in the cohort were identified during the follow-up period. We estimated yearly PM2.5 at the residential address for each CKD patient based on a satellite-based spatiotemporal model. We used Cox proportional hazards models with attained age as the underlying timescale to assess the association between long-term exposure to PM2.5 and cause-specific mortality among CKD patients. A total of 496 patients died during the follow-up, where 147 died from cardiovascular disease, 61 from respiratory disease and 154 from renal failure. The mortality hazard ratio (HR) per interquartile-range increase in PM2.5 (4.0 μg/m3) was 1.97 (95% confidence interval (CI): 1.34 to 2.91) for ischemic heart disease (IHD) among CKD patients, and was 1.42 (95%CI: 1.05 to 1.93) for CKD among those patients concomitantly with hypertension. Associations were not of statistical significance between PM2.5 and mortality hazard ratios of all-cause, stroke, and pneumonia among CKD patients. Our findings suggest that long-term exposure to PM2.5 may contribute to the CKD progression into ischemic heart diseases.-
dc.languageeng-
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/chemosphere-
dc.relation.ispartofChemosphere-
dc.subjectFine particulate matter-
dc.subjectChronic kidney disease-
dc.subjectIschemic heart disease-
dc.subjectCohort study-
dc.titleFine particulate matter and cause-specific mortality in the Hong Kong elder patients with chronic kidney disease-
dc.typeArticle-
dc.identifier.emailLi, JC: claire20@HKUCC-COM.hku.hk-
dc.identifier.emailTian, L: linweit@hku.hk-
dc.identifier.authorityTian, L=rp01991-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.chemosphere.2020.125913-
dc.identifier.pmid31962222-
dc.identifier.scopuseid_2-s2.0-85077916982-
dc.identifier.hkuros309388-
dc.identifier.volume247-
dc.identifier.spagearticle no. 125913-
dc.identifier.epagearticle no. 125913-
dc.publisher.placeUnited Kingdom-

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