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Article: Polymorphisms in complement system genes and risk of non-Hodgkin lymphoma

TitlePolymorphisms in complement system genes and risk of non-Hodgkin lymphoma
Authors
Keywordslymphoma
C1RL
innate immunity
SNP
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/10009058
Citation
Environmental and Molecular Mutagenesis, 2012, v. 53 n. 2, p. 145-151 How to Cite?
AbstractThe complement system plays an important role in inflammatory and immune responses, and recent evidence has suggested that it may also play a role in lymphomagenesis. We evaluated the association between genetic variation in complement system genes and risk of non-Hodgkin lymphoma (NHL) in a population-based case-control study conducted among women in Connecticut. Tag SNPs in 30 complement genes were genotyped in 432 Caucasian incident cases and 494 frequency-matched controls. A gene-based analysis that adjusted for the number of tag SNPs genotyped in each gene showed a significant association with NHL overall (P = 0.04) as well as with diffuse large B-cell lymphoma (DLBCL) (P = 0.01) for the C1RL gene. A SNP-based analysis showed that a C>T base substitution for C1RL rs3813729 (odds ratio (OR)(CT) = 0.60, 95% confidence interval (CI) = 0.42-0.87, P(trend) = 0.0062) was associated with a decreased risk of overall NHL, as well as for DLBCL (OR(CT) = 0.39, 95% CI = 0.20-0.73; P(trend) = 0.0034). Additionally, SNPs (C2 rs497309, A>C and C3 rs344550, G>C) in two complement genes were positively associated with marginal zone lymphoma (MZL) and C1QG was associated with CLL/SLL, but these results were based on a limited number of cases. Our results suggest a potential role of the complement system in susceptibility to NHL; however, our results should be viewed as exploratory and further replication is needed to clarify these preliminary findings.
Persistent Identifierhttp://hdl.handle.net/10722/281247
ISSN
2017 Impact Factor: 3.254
2015 SCImago Journal Rankings: 1.326
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorBassig, BA-
dc.contributor.authorZheng, T-
dc.contributor.authorZhang, Y-
dc.contributor.authorBerndt, SI-
dc.contributor.authorHolford, TR-
dc.contributor.authorHosgood, HD 3rd-
dc.contributor.authorHu, W-
dc.contributor.authorLeaderer, B-
dc.contributor.authorYeager, M-
dc.contributor.authorMenashe, I-
dc.contributor.authorBoyle, P-
dc.contributor.authorXu, J-
dc.contributor.authorZou, K-
dc.contributor.authorZhu, Y-
dc.contributor.authorChanock, S-
dc.contributor.authorRothman, N-
dc.contributor.authorLan, Q-
dc.date.accessioned2020-03-09T09:52:05Z-
dc.date.available2020-03-09T09:52:05Z-
dc.date.issued2012-
dc.identifier.citationEnvironmental and Molecular Mutagenesis, 2012, v. 53 n. 2, p. 145-151-
dc.identifier.issn0893-6692-
dc.identifier.urihttp://hdl.handle.net/10722/281247-
dc.description.abstractThe complement system plays an important role in inflammatory and immune responses, and recent evidence has suggested that it may also play a role in lymphomagenesis. We evaluated the association between genetic variation in complement system genes and risk of non-Hodgkin lymphoma (NHL) in a population-based case-control study conducted among women in Connecticut. Tag SNPs in 30 complement genes were genotyped in 432 Caucasian incident cases and 494 frequency-matched controls. A gene-based analysis that adjusted for the number of tag SNPs genotyped in each gene showed a significant association with NHL overall (P = 0.04) as well as with diffuse large B-cell lymphoma (DLBCL) (P = 0.01) for the C1RL gene. A SNP-based analysis showed that a C>T base substitution for C1RL rs3813729 (odds ratio (OR)(CT) = 0.60, 95% confidence interval (CI) = 0.42-0.87, P(trend) = 0.0062) was associated with a decreased risk of overall NHL, as well as for DLBCL (OR(CT) = 0.39, 95% CI = 0.20-0.73; P(trend) = 0.0034). Additionally, SNPs (C2 rs497309, A>C and C3 rs344550, G>C) in two complement genes were positively associated with marginal zone lymphoma (MZL) and C1QG was associated with CLL/SLL, but these results were based on a limited number of cases. Our results suggest a potential role of the complement system in susceptibility to NHL; however, our results should be viewed as exploratory and further replication is needed to clarify these preliminary findings.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/10009058-
dc.relation.ispartofEnvironmental and Molecular Mutagenesis-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectlymphoma-
dc.subjectC1RL-
dc.subjectinnate immunity-
dc.subjectSNP-
dc.titlePolymorphisms in complement system genes and risk of non-Hodgkin lymphoma-
dc.typeArticle-
dc.identifier.emailXu, J: xusunjun@hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/em.21675-
dc.identifier.pmid22170086-
dc.identifier.pmcidPMC3391498-
dc.identifier.scopuseid_2-s2.0-84856576991-
dc.identifier.hkuros309332-
dc.identifier.volume53-
dc.identifier.issue2-
dc.identifier.spage145-
dc.identifier.epage151-
dc.publisher.placeUnited States-

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