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Article: ‘Search less, verify more’ – Reviewing salivary biomarkers in oral cancer detection

Title‘Search less, verify more’ – Reviewing salivary biomarkers in oral cancer detection
Authors
Keywordsbiomarkers
oral squamous cell carcinoma
saliva
Issue Date2020
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0714
Citation
Journal of Oral Pathology & Medicine, 2020, v. 49 n. 8, p. 711-719 How to Cite?
AbstractOral squamous cell carcinoma is one of the commonest head and neck malignancies with approximately 350,000 cases reported annually and a mortality rate of 50% often attributed to late clinical presentation. Due to the close relationship between saliva bio‐fluid and tumour lesions, optimizing salivary biomarkers for disease detection and screening provides a major new research direction in diagnostic oral oncology. As inter‐ and intra‐tumour heterogeneity are common within oral cavity neoplasms, it is unlikely that a single diagnostic or ‘risk‐stratifying’ saliva biomarker will suffice for universal translation to clinical practice. Therefore, this article highlights a number of promising saliva biomarker combinations for oral cavity cancer detection that require further research and validation to determine their true diagnostic potential.
Persistent Identifierhttp://hdl.handle.net/10722/280961
ISSN
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.716
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorADEOYE, J-
dc.contributor.authorBrennan, PA-
dc.contributor.authorThomson, PJ-
dc.date.accessioned2020-02-25T07:43:19Z-
dc.date.available2020-02-25T07:43:19Z-
dc.date.issued2020-
dc.identifier.citationJournal of Oral Pathology & Medicine, 2020, v. 49 n. 8, p. 711-719-
dc.identifier.issn0904-2512-
dc.identifier.urihttp://hdl.handle.net/10722/280961-
dc.description.abstractOral squamous cell carcinoma is one of the commonest head and neck malignancies with approximately 350,000 cases reported annually and a mortality rate of 50% often attributed to late clinical presentation. Due to the close relationship between saliva bio‐fluid and tumour lesions, optimizing salivary biomarkers for disease detection and screening provides a major new research direction in diagnostic oral oncology. As inter‐ and intra‐tumour heterogeneity are common within oral cavity neoplasms, it is unlikely that a single diagnostic or ‘risk‐stratifying’ saliva biomarker will suffice for universal translation to clinical practice. Therefore, this article highlights a number of promising saliva biomarker combinations for oral cavity cancer detection that require further research and validation to determine their true diagnostic potential.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0714-
dc.relation.ispartofJournal of Oral Pathology & Medicine-
dc.rightsPostprint This is the peer reviewed version of the following article: [Journal of Oral Pathology & Medicine, 2020, v. 49 n. 8, p. 711-719], which has been published in final form at [http://dx.doi.org/10.1111/jop.13003]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectbiomarkers-
dc.subjectoral squamous cell carcinoma-
dc.subjectsaliva-
dc.title‘Search less, verify more’ – Reviewing salivary biomarkers in oral cancer detection-
dc.typeArticle-
dc.identifier.emailThomson, PJ: thomsonp@hku.hk-
dc.identifier.authorityThomson, PJ=rp02327-
dc.description.naturepostprint-
dc.identifier.doi10.1111/jop.13003-
dc.identifier.pmid32027406-
dc.identifier.scopuseid_2-s2.0-85080872992-
dc.identifier.hkuros309151-
dc.identifier.volume49-
dc.identifier.issue8-
dc.identifier.spage711-
dc.identifier.epage719-
dc.identifier.isiWOS:000561629400001-
dc.publisher.placeDenmark-
dc.identifier.issnl0904-2512-

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