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Article: Birth weight and prematurity with lung function at ~17.5 years: “Children of 1997” birth cohort
Title | Birth weight and prematurity with lung function at ~17.5 years: “Children of 1997” birth cohort |
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Authors | |
Keywords | Bronchopulmonary Dysplasia Infant Premature Supplemental oxygen |
Issue Date | 2020 |
Publisher | Nature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html |
Citation | Scientific Reports, 2020, v. 10 n. 1, p. article no. 341 How to Cite? |
Abstract | We aimed to determine if prematurity and lower birth weight are associated with poorer lung function in a non-western developed setting with less marked confounding by socioeconomic position. Using multivariable linear regression in Hong Kong’s “Children of 1997” birth cohort, adjusted associations of prematurity and birth weight with forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and forced expiratory flow at 25–75% of the pulmonary volume (FEF25–75%) at ~17.5 years were assessed. Associations for birth weight were stronger in boys for FEV1 (boys: 0.31 L, 95% confidence interval (CI) 0.24 to 0.38, girls: 0.18 L, 95% CI 0.12 to 0.25), FVC (boys: 0.36 L, 95% CI 0.27 to 0.44, girls: 0.22 L, 95% CI 0.15 to 0.28) and FEF25–75% (boys: 0.35 L, 95% CI 0.21 to 0.49, girls: 0.22 L, 95% CI 0.09 to 0.34) adjusted for age, socioeconomic position and infant and maternal characteristics. Similarly adjusted, preterm birth (compared to full-term birth) was associated with lower FEV1/FVC and FEF25–75%. Thus, associations of lower birth weight, especially in boys, and prematurity with poorer lung function at 17.5 years were found. Identifying underlying mechanism might contribute to the improvement of pulmonary health and the prevention of adult respiratory illness. |
Persistent Identifier | http://hdl.handle.net/10722/280904 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 0.900 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | HE, B | - |
dc.contributor.author | Kwok, MK | - |
dc.contributor.author | Au Yeung, SL | - |
dc.contributor.author | Lin, SC | - |
dc.contributor.author | Leung, JYY | - |
dc.contributor.author | Hui, LL | - |
dc.contributor.author | Li, AM | - |
dc.contributor.author | Leung, GM | - |
dc.contributor.author | Schooling, CM | - |
dc.date.accessioned | 2020-02-25T07:42:26Z | - |
dc.date.available | 2020-02-25T07:42:26Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Scientific Reports, 2020, v. 10 n. 1, p. article no. 341 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10722/280904 | - |
dc.description.abstract | We aimed to determine if prematurity and lower birth weight are associated with poorer lung function in a non-western developed setting with less marked confounding by socioeconomic position. Using multivariable linear regression in Hong Kong’s “Children of 1997” birth cohort, adjusted associations of prematurity and birth weight with forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and forced expiratory flow at 25–75% of the pulmonary volume (FEF25–75%) at ~17.5 years were assessed. Associations for birth weight were stronger in boys for FEV1 (boys: 0.31 L, 95% confidence interval (CI) 0.24 to 0.38, girls: 0.18 L, 95% CI 0.12 to 0.25), FVC (boys: 0.36 L, 95% CI 0.27 to 0.44, girls: 0.22 L, 95% CI 0.15 to 0.28) and FEF25–75% (boys: 0.35 L, 95% CI 0.21 to 0.49, girls: 0.22 L, 95% CI 0.09 to 0.34) adjusted for age, socioeconomic position and infant and maternal characteristics. Similarly adjusted, preterm birth (compared to full-term birth) was associated with lower FEV1/FVC and FEF25–75%. Thus, associations of lower birth weight, especially in boys, and prematurity with poorer lung function at 17.5 years were found. Identifying underlying mechanism might contribute to the improvement of pulmonary health and the prevention of adult respiratory illness. | - |
dc.language | eng | - |
dc.publisher | Nature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Bronchopulmonary Dysplasia | - |
dc.subject | Infant | - |
dc.subject | Premature | - |
dc.subject | Supplemental oxygen | - |
dc.title | Birth weight and prematurity with lung function at ~17.5 years: “Children of 1997” birth cohort | - |
dc.type | Article | - |
dc.identifier.email | Kwok, MK: maggiek@hku.hk | - |
dc.identifier.email | Au Yeung, SL: ayslryan@hku.hk | - |
dc.identifier.email | Lin, SC: lincindy@hku.hk | - |
dc.identifier.email | Leung, JYY: leungjy@hku.hk | - |
dc.identifier.email | Hui, LL: huic@hkucc.hku.hk | - |
dc.identifier.email | Leung, GM: gmleung@hku.hk | - |
dc.identifier.email | Schooling, CM: cms1@hkucc.hku.hk | - |
dc.identifier.authority | Kwok, MK=rp02051 | - |
dc.identifier.authority | Au Yeung, SL=rp02224 | - |
dc.identifier.authority | Leung, JYY=rp01817 | - |
dc.identifier.authority | Hui, LL=rp01698 | - |
dc.identifier.authority | Leung, GM=rp00460 | - |
dc.identifier.authority | Schooling, CM=rp00504 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41598-019-56086-7 | - |
dc.identifier.pmid | 31941940 | - |
dc.identifier.pmcid | PMC6962201 | - |
dc.identifier.scopus | eid_2-s2.0-85077942096 | - |
dc.identifier.hkuros | 309157 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 341 | - |
dc.identifier.epage | article no. 341 | - |
dc.identifier.isi | WOS:000551443500001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2045-2322 | - |