File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Mortality in patients with schizophrenia admitted for incident ischemic stroke: A population-based cohort study

TitleMortality in patients with schizophrenia admitted for incident ischemic stroke: A population-based cohort study
Authors
KeywordsIschemic stroke
Mortality
Population-based study
Schizophrenia
Stroke
Issue Date2020
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/euroneuro
Citation
European Neuropsychopharmacology, 2020, v. 31, p. 152-157 How to Cite?
AbstractEvidence shows that schizophrenia is associated with increased incidence of stroke. However, relationship between schizophrenia and short-term mortality risk is understudied, and mixed findings were observed. In this retrospective population-based cohort study, we identified individuals admitted for incident ischemic stroke between 2006 and 2016 using a territory-wide electronic medical record database of public healthcare system in Hong Kong to examine 30-day and 1-year mortality rates in 817 schizophrenia patients compared with 8170 patients without psychotic disorder (10:1 matched to schizophrenia patients on demographics, treatment sites and calendar-period for index admission). Multivariate regression analyses adjusting for medical comorbidities revealed that schizophrenia patients experienced elevated 1-year (16.9% vs 12.1%; p < 0.001) and 30-day mortality (7.2% vs 5.3%; p = 0.053) relative to control group. Additional age- and gender-stratified analyses revealed even more pronounced effect of schizophrenia on raised mortality risk, as indicated by higher odds, in younger-age (<65 years) group and men. Our results indicate that schizophrenia is associated with heightened short-term mortality following incident ischemic stroke. Further research is warranted to identify factors contributing to excess post-stroke deaths among schizophrenia patients to facilitate development of effective interventions for mortality risk reduction.
Persistent Identifierhttp://hdl.handle.net/10722/280388
ISSN
2020 Impact Factor: 4.6
2015 SCImago Journal Rankings: 1.851
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYung, NCL-
dc.contributor.authorWong, CSM-
dc.contributor.authorChan, JKN-
dc.contributor.authorOr, PCF-
dc.contributor.authorChen, EYH-
dc.contributor.authorChang, WC-
dc.date.accessioned2020-02-07T07:40:18Z-
dc.date.available2020-02-07T07:40:18Z-
dc.date.issued2020-
dc.identifier.citationEuropean Neuropsychopharmacology, 2020, v. 31, p. 152-157-
dc.identifier.issn0924-977X-
dc.identifier.urihttp://hdl.handle.net/10722/280388-
dc.description.abstractEvidence shows that schizophrenia is associated with increased incidence of stroke. However, relationship between schizophrenia and short-term mortality risk is understudied, and mixed findings were observed. In this retrospective population-based cohort study, we identified individuals admitted for incident ischemic stroke between 2006 and 2016 using a territory-wide electronic medical record database of public healthcare system in Hong Kong to examine 30-day and 1-year mortality rates in 817 schizophrenia patients compared with 8170 patients without psychotic disorder (10:1 matched to schizophrenia patients on demographics, treatment sites and calendar-period for index admission). Multivariate regression analyses adjusting for medical comorbidities revealed that schizophrenia patients experienced elevated 1-year (16.9% vs 12.1%; p < 0.001) and 30-day mortality (7.2% vs 5.3%; p = 0.053) relative to control group. Additional age- and gender-stratified analyses revealed even more pronounced effect of schizophrenia on raised mortality risk, as indicated by higher odds, in younger-age (<65 years) group and men. Our results indicate that schizophrenia is associated with heightened short-term mortality following incident ischemic stroke. Further research is warranted to identify factors contributing to excess post-stroke deaths among schizophrenia patients to facilitate development of effective interventions for mortality risk reduction.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/euroneuro-
dc.relation.ispartofEuropean Neuropsychopharmacology-
dc.subjectIschemic stroke-
dc.subjectMortality-
dc.subjectPopulation-based study-
dc.subjectSchizophrenia-
dc.subjectStroke-
dc.titleMortality in patients with schizophrenia admitted for incident ischemic stroke: A population-based cohort study-
dc.typeArticle-
dc.identifier.emailWong, CSM: wongcsm@hku.hk-
dc.identifier.emailChan, JKN: kwunnam@hku.hk-
dc.identifier.emailChen, EYH: eyhchen@hku.hk-
dc.identifier.emailChang, WC: changwc@hku.hk-
dc.identifier.authorityWong, CSM=rp02625-
dc.identifier.authorityChen, EYH=rp00392-
dc.identifier.authorityChang, WC=rp01465-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.euroneuro.2019.12.107-
dc.identifier.pmid31883653-
dc.identifier.scopuseid_2-s2.0-85077001176-
dc.identifier.hkuros309122-
dc.identifier.hkuros316159-
dc.identifier.volume31-
dc.identifier.spage152-
dc.identifier.epage157-
dc.identifier.isiWOS:000510016600013-
dc.publisher.placeNetherlands-
dc.identifier.issnl0924-977X-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats