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Article: Efficacy of Scaffold‐Mediated Localized Chemotherapy in Cancer: A systematic review of current research

TitleEfficacy of Scaffold‐Mediated Localized Chemotherapy in Cancer: A systematic review of current research
Authors
KeywordsCancer
Chemotherapy
research
Scaffold
Systemic review
Issue Date2020
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0714
Citation
Journal of Oral Pathology & Medicine, 2020 How to Cite?
AbstractObjective: To assess the efficacy of scaffold‐mediated localized chemotherapy in cancer. Methods: Databases including PubMed, Cochrane Library, and SCOPUS were searched for articles reporting the use of scaffold‐mediated localized drug delivery in cancer. Essential data including scaffold fabrication material and methods, drug dosage and release duration and its effect on the cancer cells were extracted. Results: 15 articles out of 60 screened, fulfilled the eligibility criteria. Among the 15 studies, 5 studies included only cell lines and 2 studies were on mouse models, while 8 studies involved a combination of cell lines and mouse models. Scaffold materials included both synthetic polymers such as poly‐lactide, polycaprolactone and natural materials including d‐periosteum and human micro‐fragmented adipose tissueA wide number of other variables included the fabrication procedure, drugs used, and the methods used to assess the effects on cancer. As a result, it was not possible to make any direct comparison of the efficacy of the therapeutic strategy used in each of these studies. Conclusion: Irrespective of the many variables, a common consensus in all the included studies was that scaffold mediated localized drug delivery effectively reduced cancer cell viability by increasing drug bioavailability to the target tissue, while its localized effect reduced the risk of systemic toxicity.
Persistent Identifierhttp://hdl.handle.net/10722/280357
ISSN
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.716
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGupta, AA-
dc.contributor.authorKheur, S-
dc.contributor.authorArakeri, G-
dc.contributor.authorThirumai, A-
dc.contributor.authorBadhe, RV-
dc.contributor.authorPatil, S-
dc.contributor.authorRao US, V-
dc.contributor.authorPatil, H-
dc.contributor.authorSantiago Gomez, R-
dc.contributor.authorThomson, P-
dc.contributor.authorBrennan, PA-
dc.date.accessioned2020-02-07T07:39:56Z-
dc.date.available2020-02-07T07:39:56Z-
dc.date.issued2020-
dc.identifier.citationJournal of Oral Pathology & Medicine, 2020-
dc.identifier.issn0904-2512-
dc.identifier.urihttp://hdl.handle.net/10722/280357-
dc.description.abstractObjective: To assess the efficacy of scaffold‐mediated localized chemotherapy in cancer. Methods: Databases including PubMed, Cochrane Library, and SCOPUS were searched for articles reporting the use of scaffold‐mediated localized drug delivery in cancer. Essential data including scaffold fabrication material and methods, drug dosage and release duration and its effect on the cancer cells were extracted. Results: 15 articles out of 60 screened, fulfilled the eligibility criteria. Among the 15 studies, 5 studies included only cell lines and 2 studies were on mouse models, while 8 studies involved a combination of cell lines and mouse models. Scaffold materials included both synthetic polymers such as poly‐lactide, polycaprolactone and natural materials including d‐periosteum and human micro‐fragmented adipose tissueA wide number of other variables included the fabrication procedure, drugs used, and the methods used to assess the effects on cancer. As a result, it was not possible to make any direct comparison of the efficacy of the therapeutic strategy used in each of these studies. Conclusion: Irrespective of the many variables, a common consensus in all the included studies was that scaffold mediated localized drug delivery effectively reduced cancer cell viability by increasing drug bioavailability to the target tissue, while its localized effect reduced the risk of systemic toxicity.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0714-
dc.relation.ispartofJournal of Oral Pathology & Medicine-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectCancer-
dc.subjectChemotherapy-
dc.subjectresearch-
dc.subjectScaffold-
dc.subjectSystemic review-
dc.titleEfficacy of Scaffold‐Mediated Localized Chemotherapy in Cancer: A systematic review of current research-
dc.typeArticle-
dc.identifier.emailThomson, P: thomsonp@hku.hk-
dc.identifier.authorityThomson, P=rp02327-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jop.12994-
dc.identifier.scopuseid_2-s2.0-85080996401-
dc.identifier.hkuros309115-
dc.identifier.isiWOS:000517774100001-
dc.publisher.placeDenmark-
dc.identifier.issnl0904-2512-

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