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Article: Serum tumor markers and positron emission tomography-computed tomography scan as post-breast cancer treatment surveillance
Title | Serum tumor markers and positron emission tomography-computed tomography scan as post-breast cancer treatment surveillance |
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Authors | |
Keywords | Breast neoplasm tumor marker recurrence |
Issue Date | 2019 |
Publisher | AME Publishing Company. The Journal's web site is located at http://abs.amegroups.com/ |
Citation | Annals of Breast Surgery, 2019, v. 3, article no. 30 How to Cite? |
Abstract | Background: Post-operative surveillance is an important aspect in managing breast cancers. The primary aim is to allow early detection of metachronous breast cancers. However, post-operative breast cancer surveillance has not been standardized. Mammography has been the only evidence-based imaging modality for detecting metachronous breast cancers. The value of regular monitoring with serum carcinoembryonic antigen (CEA) and CA 15-3 has been controversial. The aim of this study is to evaluate the efficacy of using tumor markers as a surveillance tool in post-operative patients.
Methods: This is a retrospective review of all post-breast cancer surgery patients monitored with tumor markers from 2005–2010. Correlation between tumor markers and subsequent detection of metachronous breast cancer was evaluated. Long-term survival data was analyzed.
Results: Six hundred and forty-nine patients underwent positron emission tomography-computed tomography (PET-CT) scan, 250 patients had regular tumor markers monitoring. By using 5 ng/mL as cutoff for CEA, and 23 U/mL for CA 15.3, elevated levels are associated with development of metachronous breast cancer (P=0.004 and P<0.001). The positive predictive values of CEA and CA 15.3 were 61.8% and 64.1% respectively. After median follow-up interval of 8 years after primary operation (range, 2–13 years). There were 93 breast-cancer related mortalities, 47 had elevated tumor marker, 142 patients remained disease free, 27 patients had elevated tumor marker levels. Elevated tumor marker during surveillance is associated with breast-cancer mortality in the current study (P<0.001).
Conclusions: Elevated serum CEA and CA 15-3 is associated with metachronous breast cancer and is associated with adverse long-term survival outcome. |
Description | Link to Open access |
Persistent Identifier | http://hdl.handle.net/10722/280252 |
ISSN |
DC Field | Value | Language |
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dc.contributor.author | Co, M | - |
dc.contributor.author | Man, V | - |
dc.contributor.author | Kwong, A | - |
dc.date.accessioned | 2020-01-21T11:50:48Z | - |
dc.date.available | 2020-01-21T11:50:48Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Annals of Breast Surgery, 2019, v. 3, article no. 30 | - |
dc.identifier.issn | 2616-2776 | - |
dc.identifier.uri | http://hdl.handle.net/10722/280252 | - |
dc.description | Link to Open access | - |
dc.description.abstract | Background: Post-operative surveillance is an important aspect in managing breast cancers. The primary aim is to allow early detection of metachronous breast cancers. However, post-operative breast cancer surveillance has not been standardized. Mammography has been the only evidence-based imaging modality for detecting metachronous breast cancers. The value of regular monitoring with serum carcinoembryonic antigen (CEA) and CA 15-3 has been controversial. The aim of this study is to evaluate the efficacy of using tumor markers as a surveillance tool in post-operative patients. Methods: This is a retrospective review of all post-breast cancer surgery patients monitored with tumor markers from 2005–2010. Correlation between tumor markers and subsequent detection of metachronous breast cancer was evaluated. Long-term survival data was analyzed. Results: Six hundred and forty-nine patients underwent positron emission tomography-computed tomography (PET-CT) scan, 250 patients had regular tumor markers monitoring. By using 5 ng/mL as cutoff for CEA, and 23 U/mL for CA 15.3, elevated levels are associated with development of metachronous breast cancer (P=0.004 and P<0.001). The positive predictive values of CEA and CA 15.3 were 61.8% and 64.1% respectively. After median follow-up interval of 8 years after primary operation (range, 2–13 years). There were 93 breast-cancer related mortalities, 47 had elevated tumor marker, 142 patients remained disease free, 27 patients had elevated tumor marker levels. Elevated tumor marker during surveillance is associated with breast-cancer mortality in the current study (P<0.001). Conclusions: Elevated serum CEA and CA 15-3 is associated with metachronous breast cancer and is associated with adverse long-term survival outcome. | - |
dc.language | eng | - |
dc.publisher | AME Publishing Company. The Journal's web site is located at http://abs.amegroups.com/ | - |
dc.relation.ispartof | Annals of Breast Surgery | - |
dc.subject | Breast neoplasm | - |
dc.subject | tumor marker | - |
dc.subject | recurrence | - |
dc.title | Serum tumor markers and positron emission tomography-computed tomography scan as post-breast cancer treatment surveillance | - |
dc.type | Article | - |
dc.identifier.email | Co, M: mcth@hku.hk | - |
dc.identifier.email | Kwong, A: avakwong@hku.hk | - |
dc.identifier.authority | Co, M=rp02101 | - |
dc.identifier.authority | Kwong, A=rp01734 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.21037/abs.2019.10.01 | - |
dc.identifier.hkuros | 308966 | - |
dc.identifier.hkuros | 311820 | - |
dc.identifier.volume | 3 | - |
dc.identifier.spage | article no. 30 | - |
dc.identifier.epage | article no. 30 | - |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 2616-2776 | - |