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Article: Surfactant Tracheobronchial Lavage for the Management of a Rabbit Model of Meconium Aspiration Syndrome
Title | Surfactant Tracheobronchial Lavage for the Management of a Rabbit Model of Meconium Aspiration Syndrome |
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Authors | |
Keywords | Lavage Meconium aspiration syndrome Pulmonary surfactants |
Issue Date | 2000 |
Publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/BON |
Citation | Biology of the Neonate, 2000, v. 78 n. 2, p. 129-138 How to Cite? |
Abstract | We evaluated the effect of tracheobronchial lavage with diluted surfactant solution (bovine lipid extract surfactant, bLES) in a rabbit model of meconium aspiration. All animals were anaesthetized, tracheotomized and given 3-4 ml/kg of 25% slurry of human meconium into the endotracheal tube and mechanically ventilated for 1 h. The animals were then randomly assigned to surfactant lavage (n = 12) with 15 ml/kg of diluted surfactant at a concentration of 5.4 mg phospholipid/ml administered in aliquots of 2 ml; or simple endotracheal suction (control n = 12) when the oxygenation index (OI) was >/=15. Changes in the arterial blood gases and the histomorphological and radiological appearances of the lungs were recorded. The OI and arterial/alveolar oxygen tension (a/A PO2) of the surfactant lavage group improved significantly at 5 min post-treatment, and these improvements were observed throughout the ensuing 4 h of ventilation. There was significantly more solid content recovered by surfactant lavage compared with the control group (p = 0.0001). Radiologically, the post-treatment air space opacification scores of the lavage group were significantly lower compared with the control (p = 0.002). The post-treatment radiographs of the lavage-treated rabbits were rated by the radiologist, who was blinded to the treatment groups, as much improved in 5 and improved in 4, whereas the control rabbits were rated as much worse in 3 and worse in 4. Histological examination showed the lungs of the lavaged rabbits had significantly more normal airway (p < 0.0001), more fields showing completely normal airspace (p = 0.0001) and less fields showing severe overdistension with meconium (p = 0.0005). We concluded that lavage with diluted surfactant solution effectively washed out the meconium, improved gases exchanges, and improved the histological and radiological appearances in the rabbit model of MAS. |
Persistent Identifier | http://hdl.handle.net/10722/280046 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lam, BCC | - |
dc.contributor.author | Yeung, CY | - |
dc.contributor.author | Fu, KH | - |
dc.contributor.author | Wong, KY | - |
dc.contributor.author | Chan, FL | - |
dc.contributor.author | Tsoi, NS | - |
dc.date.accessioned | 2020-01-02T02:28:49Z | - |
dc.date.available | 2020-01-02T02:28:49Z | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Biology of the Neonate, 2000, v. 78 n. 2, p. 129-138 | - |
dc.identifier.issn | 0006-3126 | - |
dc.identifier.uri | http://hdl.handle.net/10722/280046 | - |
dc.description.abstract | We evaluated the effect of tracheobronchial lavage with diluted surfactant solution (bovine lipid extract surfactant, bLES) in a rabbit model of meconium aspiration. All animals were anaesthetized, tracheotomized and given 3-4 ml/kg of 25% slurry of human meconium into the endotracheal tube and mechanically ventilated for 1 h. The animals were then randomly assigned to surfactant lavage (n = 12) with 15 ml/kg of diluted surfactant at a concentration of 5.4 mg phospholipid/ml administered in aliquots of 2 ml; or simple endotracheal suction (control n = 12) when the oxygenation index (OI) was >/=15. Changes in the arterial blood gases and the histomorphological and radiological appearances of the lungs were recorded. The OI and arterial/alveolar oxygen tension (a/A PO2) of the surfactant lavage group improved significantly at 5 min post-treatment, and these improvements were observed throughout the ensuing 4 h of ventilation. There was significantly more solid content recovered by surfactant lavage compared with the control group (p = 0.0001). Radiologically, the post-treatment air space opacification scores of the lavage group were significantly lower compared with the control (p = 0.002). The post-treatment radiographs of the lavage-treated rabbits were rated by the radiologist, who was blinded to the treatment groups, as much improved in 5 and improved in 4, whereas the control rabbits were rated as much worse in 3 and worse in 4. Histological examination showed the lungs of the lavaged rabbits had significantly more normal airway (p < 0.0001), more fields showing completely normal airspace (p = 0.0001) and less fields showing severe overdistension with meconium (p = 0.0005). We concluded that lavage with diluted surfactant solution effectively washed out the meconium, improved gases exchanges, and improved the histological and radiological appearances in the rabbit model of MAS. | - |
dc.language | eng | - |
dc.publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/BON | - |
dc.relation.ispartof | Biology of the Neonate | - |
dc.rights | Biology of the Neonate. Copyright © S Karger AG. | - |
dc.rights | This is the peer-reviewed but unedited manuscript version of the following article: [insert full citation, e.g., Cytogenet Genome Res 2014;142:227–238 (DOI: 10.1159/000361001)]. The final, published version is available at http://www.karger.com/?doi=[insert DOI number]. OR This is the un-reviewed and unedited manuscript version of the following article: [insert full citation, e.g., Cytogenet Genome Res 2014;142:227–238 (DOI: 10.1159/000361001)]. The final, published version is available at http://www.karger.com/?doi=[insert DOI number]. | - |
dc.subject | Lavage | - |
dc.subject | Meconium aspiration syndrome | - |
dc.subject | Pulmonary surfactants | - |
dc.title | Surfactant Tracheobronchial Lavage for the Management of a Rabbit Model of Meconium Aspiration Syndrome | - |
dc.type | Article | - |
dc.identifier.email | Lam, BCC: lamccb@HKUCC.hku.hk | - |
dc.identifier.email | Yeung, CY: hrmpycy@hkucc.hku.hk | - |
dc.identifier.email | Wong, KY: kywongb@HKUCC.hku.hk | - |
dc.identifier.email | Tsoi, NS: tsoins@hkucc.hku.hk | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1159/000014261 | - |
dc.identifier.pmid | 10971006 | - |
dc.identifier.scopus | eid_2-s2.0-0033822999 | - |
dc.identifier.hkuros | 55806 | - |
dc.identifier.volume | 78 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 129 | - |
dc.identifier.epage | 138 | - |
dc.identifier.isi | WOS:000089279900010 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 0006-3126 | - |