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Article: A double‐blind, paralleled‐arm, placebo‐controlled and randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care

TitleA double‐blind, paralleled‐arm, placebo‐controlled and randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care
Authors
Keywordsadjunct care
Lactobacillus reuteri
non‐surgical periodontal therapy
probiotics
Issue Date2019
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-051X
Citation
Journal of Clinical Periodontology, 2019, v. 46 n. 12, p. 1217-1227 How to Cite?
AbstractAim: This study aimed to evaluate the clinical effectiveness of the probiotic Lactobacillus reuteri as an adjunct to non‐surgical periodontal therapy (NSPT). Materials and Methods: A double‐blind, paralleled‐arm, placebo‐controlled and randomized clinical trial was conducted. Probiotics L. reuteri or placebo lozenges were randomly prescribed for use twice‐daily for 28 days. Primary outcomes were clinical attachment levels (CAL) and probing pocket depths (PPD). All participants underwent NSPT, and follow‐up clinical assessments were performed at day 90 and day 180. Results: The trial response rate was 69.5% (41 out of 59). Among the test and control groups, there were significant intra‐group differences in primary outcomes: CAL (both, p < .001) and PPD (both, p < .001); and in secondary outcomes: percentage of sites with ‘bleeding on probing’ (both, p < .001) and visible plaque (both, p < .001). There were no statistically significant inter‐group differences in any outcomes at any time points (all, p > .05) nor in the changes in outcomes (∆) with time (all, p > .05). There was a trend of a greater magnitude of statistical change occurring among the test group compared to the control group. Conclusion: The adjunctive use of probiotics with NSPT did not show any additional clinical effectiveness when compared to NSPT alone in the management of periodontitis (ChiCTR‐IOR‐17010526).
Persistent Identifierhttp://hdl.handle.net/10722/279968
ISSN
2020 Impact Factor: 8.728
2020 SCImago Journal Rankings: 3.456
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPelekos, G-
dc.contributor.authorHO, SN-
dc.contributor.authorAcharya, A-
dc.contributor.authorLeung, WK-
dc.contributor.authorMcGrath, C-
dc.date.accessioned2019-12-23T08:24:22Z-
dc.date.available2019-12-23T08:24:22Z-
dc.date.issued2019-
dc.identifier.citationJournal of Clinical Periodontology, 2019, v. 46 n. 12, p. 1217-1227-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/279968-
dc.description.abstractAim: This study aimed to evaluate the clinical effectiveness of the probiotic Lactobacillus reuteri as an adjunct to non‐surgical periodontal therapy (NSPT). Materials and Methods: A double‐blind, paralleled‐arm, placebo‐controlled and randomized clinical trial was conducted. Probiotics L. reuteri or placebo lozenges were randomly prescribed for use twice‐daily for 28 days. Primary outcomes were clinical attachment levels (CAL) and probing pocket depths (PPD). All participants underwent NSPT, and follow‐up clinical assessments were performed at day 90 and day 180. Results: The trial response rate was 69.5% (41 out of 59). Among the test and control groups, there were significant intra‐group differences in primary outcomes: CAL (both, p < .001) and PPD (both, p < .001); and in secondary outcomes: percentage of sites with ‘bleeding on probing’ (both, p < .001) and visible plaque (both, p < .001). There were no statistically significant inter‐group differences in any outcomes at any time points (all, p > .05) nor in the changes in outcomes (∆) with time (all, p > .05). There was a trend of a greater magnitude of statistical change occurring among the test group compared to the control group. Conclusion: The adjunctive use of probiotics with NSPT did not show any additional clinical effectiveness when compared to NSPT alone in the management of periodontitis (ChiCTR‐IOR‐17010526).-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-051X-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectadjunct care-
dc.subjectLactobacillus reuteri-
dc.subjectnon‐surgical periodontal therapy-
dc.subjectprobiotics-
dc.titleA double‐blind, paralleled‐arm, placebo‐controlled and randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care-
dc.typeArticle-
dc.identifier.emailPelekos, G: george74@hku.hk-
dc.identifier.emailAcharya, A: aneesha@hku.hk-
dc.identifier.emailLeung, WK: ewkleung@hkucc.hku.hk-
dc.identifier.emailMcGrath, C: mcgrathc@hkucc.hku.hk-
dc.identifier.authorityPelekos, G=rp01894-
dc.identifier.authorityLeung, WK=rp00019-
dc.identifier.authorityMcGrath, C=rp00037-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jcpe.13191-
dc.identifier.pmid31479530-
dc.identifier.scopuseid_2-s2.0-85074566173-
dc.identifier.hkuros308708-
dc.identifier.volume46-
dc.identifier.issue12-
dc.identifier.spage1217-
dc.identifier.epage1227-
dc.identifier.isiWOS:000492823700001-
dc.publisher.placeUnited States-
dc.identifier.issnl0303-6979-

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