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Article: Genetic scores for BMI related to metabolically unhealthy obesity in an older Chinese population

TitleGenetic scores for BMI related to metabolically unhealthy obesity in an older Chinese population
Authors
KeywordsChina
cohort study
genetic risk score
metabolically unhealthy obese
overweight
Issue Date2019
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664
Citation
Clinical Endocrinology, 2019, v. 91 n. 6, p. 759-769 How to Cite?
AbstractObjective: In this study, a genetic risk score (GRS) for the body mass index (BMI) tested and built using a large sample of Chinese individuals aged at least 50 years in southern China. We collected information regarding the participants’ weights at 20 years of age and middle age and tested the BMI‐GRS effect modes. Methods: This study involved a prospective study design. The genetic data of the participants in from the Guangzhou Biobank Cohort Study and selected BMI‐related single‐nucleotide polymorphisms (SNPs) were used to establish the GRS. Results: We included 13 597 participants with 12 SNPs. After adjusting for covariates, the high‐GRS group was 36% (95% CI: 25%‐48%) and 34% (95% CI: 23%‐47%) more likely of being overweight at baseline and follow‐up, respectively, and 56% (95% CI: 34%‐82%) and 49% (95% CI: 29%‐72%) more likely of being obese at baseline and follow‐up, respectively, compared with the low‐GRS group (P‐value for all trends <.05). The RRs for the incidences of metabolically healthy and unhealthy obese (MHO and MUO, respectively) individuals in the high‐GRS group were 0.94 (95% CI: 0.65‐1.35) and 1.28 (95% CI: 1.00‐1.63), respectively. Conclusion: High‐GRS participants were more likely to be overweight/obese at baseline and follow‐up, and this relationship exhibited a dose‐response relationship. The GRS was also associated with MUO.
Persistent Identifierhttp://hdl.handle.net/10722/279896
ISSN
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 0.978
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYang, SS-
dc.contributor.authorWang, Y-
dc.contributor.authorHe, Y-
dc.contributor.authorXu, L-
dc.contributor.authorJin, Y-
dc.contributor.authorZhang, WS-
dc.contributor.authorJiang, CQ-
dc.contributor.authorCheng, KK-
dc.contributor.authorLam, TH-
dc.date.accessioned2019-12-23T08:23:22Z-
dc.date.available2019-12-23T08:23:22Z-
dc.date.issued2019-
dc.identifier.citationClinical Endocrinology, 2019, v. 91 n. 6, p. 759-769-
dc.identifier.issn0300-0664-
dc.identifier.urihttp://hdl.handle.net/10722/279896-
dc.description.abstractObjective: In this study, a genetic risk score (GRS) for the body mass index (BMI) tested and built using a large sample of Chinese individuals aged at least 50 years in southern China. We collected information regarding the participants’ weights at 20 years of age and middle age and tested the BMI‐GRS effect modes. Methods: This study involved a prospective study design. The genetic data of the participants in from the Guangzhou Biobank Cohort Study and selected BMI‐related single‐nucleotide polymorphisms (SNPs) were used to establish the GRS. Results: We included 13 597 participants with 12 SNPs. After adjusting for covariates, the high‐GRS group was 36% (95% CI: 25%‐48%) and 34% (95% CI: 23%‐47%) more likely of being overweight at baseline and follow‐up, respectively, and 56% (95% CI: 34%‐82%) and 49% (95% CI: 29%‐72%) more likely of being obese at baseline and follow‐up, respectively, compared with the low‐GRS group (P‐value for all trends <.05). The RRs for the incidences of metabolically healthy and unhealthy obese (MHO and MUO, respectively) individuals in the high‐GRS group were 0.94 (95% CI: 0.65‐1.35) and 1.28 (95% CI: 1.00‐1.63), respectively. Conclusion: High‐GRS participants were more likely to be overweight/obese at baseline and follow‐up, and this relationship exhibited a dose‐response relationship. The GRS was also associated with MUO.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664-
dc.relation.ispartofClinical Endocrinology-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectChina-
dc.subjectcohort study-
dc.subjectgenetic risk score-
dc.subjectmetabolically unhealthy obese-
dc.subjectoverweight-
dc.titleGenetic scores for BMI related to metabolically unhealthy obesity in an older Chinese population-
dc.typeArticle-
dc.identifier.emailHe, Y: yaohe@hkucc.hku.hk-
dc.identifier.emailXu, L: linxu@hku.hk-
dc.identifier.emailZhang, WS: zhangws9@hku.hk-
dc.identifier.emailJiang, CQ: cqjiang@hkucc.hku.hk-
dc.identifier.emailCheng, KK: chengkk@hkucc.hku.hk-
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hk-
dc.identifier.authorityXu, L=rp02030-
dc.identifier.authorityLam, TH=rp00326-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/cen.14077-
dc.identifier.pmid31420887-
dc.identifier.scopuseid_2-s2.0-85074367797-
dc.identifier.hkuros308694-
dc.identifier.volume91-
dc.identifier.issue6-
dc.identifier.spage759-
dc.identifier.epage769-
dc.identifier.isiWOS:000491159400001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0300-0664-

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