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Article: Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study

TitlePost-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study
Authors
Kirmeier, EvaEriksson, Lars I.Lewald, HeidrunJonsson Fagerlund, MalinHoeft, AndreasHollmann, MarkusMeistelman, ClaudeHunter, Jennifer M.Ulm, KurtBlobner, ManfredAbad Gurumeta, AlfredoBorecka-Kedzierska, MiroslawaCarl, IlyasAbernethy, CarolineAbigail, PatrickAchaibar, KiraAdam, EmilyAfshari, ArashAgudelo Montoya, M. ElizabethAkgün, Fatma NurAletti, GabrieleAlkış, NeslihanAllan, KatieAllan, AshleyAllaouchiche, BernardAllcock, ClareAlmasy, EmokeAmey, IsobelAmigoni, MariaAndersen, ElinAndersson, PederAnipchenko, NatalyaAntunes, PedroArmstrong, EarleneAslam, Tayyba NazAslin, BjornAssunção, José PedroAusserer, JuliaAvvai, MaryAwad, NahlaAyas Montero, BegoñaAyuso, MercedesAzevedo, PatriciaBadarau, VictoriaBadescu, RoxanaBaiardo Redaelli, MartinaBaird, ColinBaird, YolandaBaker, TimBalaji, PackianathaswamyBălan, CristinaBalandin, AlinaBalescu-Arion, CarmenBaliuliene, VildaBaltasar Isabel, JorgeBaluch, Saif NasrBandrabur, DanielaBankewitz, CarlaBarber, KatrinaBarbera, FrancescoBarcraft-Barnes, HelenaBarletti, ValentinaBarnett, GillBaron, KirstyBarros, AnaBarsan, VictoriaBartlett, PaulineBatistaki, ChrysanthiBaumgarten, GeorgBaytas, VolkanBeauchamp, NigelBecerra Cayetano, Isabel A.Bell, StephanieBellandi, MattiaBelletti, AlessandroBelmonte Cuenca, JulioBenitez-Cano, AdelaBeretta, LuigiBerger, MarcBergmann, NicoleBergmark, KristinaBermudez Lopez, MariaBernotaite, MonikaBeurskens, CharlotteBidd, HeenaBifulco, FrancescaBignami, ElenaBilic, AleksandarBilskiene, DianaBischoff, PetraBishop, LukeBjonness, ThereseBlaylock, HetherBlethyn, KateBlincoe, ThomasBlokhin, IvanBlunt, NadiaBoer, ChristaBois, GrégoryBonicolini, EleonoraBooth, Joanna
Issue Date2019
Citation
The Lancet Respiratory Medicine, 2019, v. 7, n. 2, p. 129-140 How to Cite?
Abstract© 2019 Elsevier Ltd Background: Results from retrospective studies suggest that use of neuromuscular blocking agents during general anaesthesia might be linked to postoperative pulmonary complications. We therefore aimed to assess whether the use of neuromuscular blocking agents is associated with postoperative pulmonary complications. Methods: We did a multicentre, prospective observational cohort study. Patients were recruited from 211 hospitals in 28 European countries. We included patients (aged ≥18 years) who received general anaesthesia for any in-hospital procedure except cardiac surgery. Patient characteristics, surgical and anaesthetic details, and chart review at discharge were prospectively collected over 2 weeks. Additionally, each patient underwent postoperative physical examination within 3 days of surgery to check for adverse pulmonary events. The study outcome was the incidence of postoperative pulmonary complications from the end of surgery up to postoperative day 28. Logistic regression analyses were adjusted for surgical factors and patients' preoperative physical status, providing adjusted odds ratios (ORadj) and adjusted absolute risk reduction (ARRadj). This study is registered with ClinicalTrials.gov, number NCT01865513. Findings: Between June 16, 2014, and April 29, 2015, data from 22 803 patients were collected. The use of neuromuscular blocking agents was associated with an increased incidence of postoperative pulmonary complications in patients who had undergone general anaesthesia (1658 [7·6%] of 21 694); ORadj 1·86, 95% CI 1·53–2·26; ARRadj −4·4%, 95% CI −5·5 to −3·2). Only 2·3% of high-risk surgical patients and those with adverse respiratory profiles were anaesthetised without neuromuscular blocking agents. The use of neuromuscular monitoring (ORadj 1·31, 95% CI 1·15–1·49; ARRadj −2·6%, 95% CI −3·9 to −1·4) and the administration of reversal agents (1·23, 1·07–1·41; −1·9%, −3·2 to −0·7) were not associated with a decreased risk of postoperative pulmonary complications. Neither the choice of sugammadex instead of neostigmine for reversal (ORadj 1·03, 95% CI 0·85–1·25; ARRadj −0·3%, 95% CI −2·4 to 1·5) nor extubation at a train-of-four ratio of 0·9 or more (1·03, 0·82–1·31; −0·4%, −3·5 to 2·2) was associated with better pulmonary outcomes. Interpretation: We showed that the use of neuromuscular blocking drugs in general anaesthesia is associated with an increased risk of postoperative pulmonary complications. Anaesthetists must balance the potential benefits of neuromuscular blockade against the increased risk of postoperative pulmonary complications. Funding: European Society of Anaesthesiology.
Persistent Identifierhttp://hdl.handle.net/10722/279361
ISSN
2021 Impact Factor: 102.642
2020 SCImago Journal Rankings: 9.030
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKirmeier, Eva-
dc.contributor.authorEriksson, Lars I.-
dc.contributor.authorLewald, Heidrun-
dc.contributor.authorJonsson Fagerlund, Malin-
dc.contributor.authorHoeft, Andreas-
dc.contributor.authorHollmann, Markus-
dc.contributor.authorMeistelman, Claude-
dc.contributor.authorHunter, Jennifer M.-
dc.contributor.authorUlm, Kurt-
dc.contributor.authorBlobner, Manfred-
dc.contributor.authorAbad Gurumeta, Alfredo-
dc.contributor.authorBorecka-Kedzierska, Miroslawa-
dc.contributor.authorCarl, Ilyas-
dc.contributor.authorAbernethy, Caroline-
dc.contributor.authorAbigail, Patrick-
dc.contributor.authorAchaibar, Kira-
dc.contributor.authorAdam, Emily-
dc.contributor.authorAfshari, Arash-
dc.contributor.authorAgudelo Montoya, M. Elizabeth-
dc.contributor.authorAkgün, Fatma Nur-
dc.contributor.authorAletti, Gabriele-
dc.contributor.authorAlkış, Neslihan-
dc.contributor.authorAllan, Katie-
dc.contributor.authorAllan, Ashley-
dc.contributor.authorAllaouchiche, Bernard-
dc.contributor.authorAllcock, Clare-
dc.contributor.authorAlmasy, Emoke-
dc.contributor.authorAmey, Isobel-
dc.contributor.authorAmigoni, Maria-
dc.contributor.authorAndersen, Elin-
dc.contributor.authorAndersson, Peder-
dc.contributor.authorAnipchenko, Natalya-
dc.contributor.authorAntunes, Pedro-
dc.contributor.authorArmstrong, Earlene-
dc.contributor.authorAslam, Tayyba Naz-
dc.contributor.authorAslin, Bjorn-
dc.contributor.authorAssunção, José Pedro-
dc.contributor.authorAusserer, Julia-
dc.contributor.authorAvvai, Mary-
dc.contributor.authorAwad, Nahla-
dc.contributor.authorAyas Montero, Begoña-
dc.contributor.authorAyuso, Mercedes-
dc.contributor.authorAzevedo, Patricia-
dc.contributor.authorBadarau, Victoria-
dc.contributor.authorBadescu, Roxana-
dc.contributor.authorBaiardo Redaelli, Martina-
dc.contributor.authorBaird, Colin-
dc.contributor.authorBaird, Yolanda-
dc.contributor.authorBaker, Tim-
dc.contributor.authorBalaji, Packianathaswamy-
dc.contributor.authorBălan, Cristina-
dc.contributor.authorBalandin, Alina-
dc.contributor.authorBalescu-Arion, Carmen-
dc.contributor.authorBaliuliene, Vilda-
dc.contributor.authorBaltasar Isabel, Jorge-
dc.contributor.authorBaluch, Saif Nasr-
dc.contributor.authorBandrabur, Daniela-
dc.contributor.authorBankewitz, Carla-
dc.contributor.authorBarber, Katrina-
dc.contributor.authorBarbera, Francesco-
dc.contributor.authorBarcraft-Barnes, Helena-
dc.contributor.authorBarletti, Valentina-
dc.contributor.authorBarnett, Gill-
dc.contributor.authorBaron, Kirsty-
dc.contributor.authorBarros, Ana-
dc.contributor.authorBarsan, Victoria-
dc.contributor.authorBartlett, Pauline-
dc.contributor.authorBatistaki, Chrysanthi-
dc.contributor.authorBaumgarten, Georg-
dc.contributor.authorBaytas, Volkan-
dc.contributor.authorBeauchamp, Nigel-
dc.contributor.authorBecerra Cayetano, Isabel A.-
dc.contributor.authorBell, Stephanie-
dc.contributor.authorBellandi, Mattia-
dc.contributor.authorBelletti, Alessandro-
dc.contributor.authorBelmonte Cuenca, Julio-
dc.contributor.authorBenitez-Cano, Adela-
dc.contributor.authorBeretta, Luigi-
dc.contributor.authorBerger, Marc-
dc.contributor.authorBergmann, Nicole-
dc.contributor.authorBergmark, Kristina-
dc.contributor.authorBermudez Lopez, Maria-
dc.contributor.authorBernotaite, Monika-
dc.contributor.authorBeurskens, Charlotte-
dc.contributor.authorBidd, Heena-
dc.contributor.authorBifulco, Francesca-
dc.contributor.authorBignami, Elena-
dc.contributor.authorBilic, Aleksandar-
dc.contributor.authorBilskiene, Diana-
dc.contributor.authorBischoff, Petra-
dc.contributor.authorBishop, Luke-
dc.contributor.authorBjonness, Therese-
dc.contributor.authorBlaylock, Hether-
dc.contributor.authorBlethyn, Kate-
dc.contributor.authorBlincoe, Thomas-
dc.contributor.authorBlokhin, Ivan-
dc.contributor.authorBlunt, Nadia-
dc.contributor.authorBoer, Christa-
dc.contributor.authorBois, Grégory-
dc.contributor.authorBonicolini, Eleonora-
dc.contributor.authorBooth, Joanna-
dc.date.accessioned2019-10-28T03:02:27Z-
dc.date.available2019-10-28T03:02:27Z-
dc.date.issued2019-
dc.identifier.citationThe Lancet Respiratory Medicine, 2019, v. 7, n. 2, p. 129-140-
dc.identifier.issn2213-2600-
dc.identifier.urihttp://hdl.handle.net/10722/279361-
dc.description.abstract© 2019 Elsevier Ltd Background: Results from retrospective studies suggest that use of neuromuscular blocking agents during general anaesthesia might be linked to postoperative pulmonary complications. We therefore aimed to assess whether the use of neuromuscular blocking agents is associated with postoperative pulmonary complications. Methods: We did a multicentre, prospective observational cohort study. Patients were recruited from 211 hospitals in 28 European countries. We included patients (aged ≥18 years) who received general anaesthesia for any in-hospital procedure except cardiac surgery. Patient characteristics, surgical and anaesthetic details, and chart review at discharge were prospectively collected over 2 weeks. Additionally, each patient underwent postoperative physical examination within 3 days of surgery to check for adverse pulmonary events. The study outcome was the incidence of postoperative pulmonary complications from the end of surgery up to postoperative day 28. Logistic regression analyses were adjusted for surgical factors and patients' preoperative physical status, providing adjusted odds ratios (ORadj) and adjusted absolute risk reduction (ARRadj). This study is registered with ClinicalTrials.gov, number NCT01865513. Findings: Between June 16, 2014, and April 29, 2015, data from 22 803 patients were collected. The use of neuromuscular blocking agents was associated with an increased incidence of postoperative pulmonary complications in patients who had undergone general anaesthesia (1658 [7·6%] of 21 694); ORadj 1·86, 95% CI 1·53–2·26; ARRadj −4·4%, 95% CI −5·5 to −3·2). Only 2·3% of high-risk surgical patients and those with adverse respiratory profiles were anaesthetised without neuromuscular blocking agents. The use of neuromuscular monitoring (ORadj 1·31, 95% CI 1·15–1·49; ARRadj −2·6%, 95% CI −3·9 to −1·4) and the administration of reversal agents (1·23, 1·07–1·41; −1·9%, −3·2 to −0·7) were not associated with a decreased risk of postoperative pulmonary complications. Neither the choice of sugammadex instead of neostigmine for reversal (ORadj 1·03, 95% CI 0·85–1·25; ARRadj −0·3%, 95% CI −2·4 to 1·5) nor extubation at a train-of-four ratio of 0·9 or more (1·03, 0·82–1·31; −0·4%, −3·5 to 2·2) was associated with better pulmonary outcomes. Interpretation: We showed that the use of neuromuscular blocking drugs in general anaesthesia is associated with an increased risk of postoperative pulmonary complications. Anaesthetists must balance the potential benefits of neuromuscular blockade against the increased risk of postoperative pulmonary complications. Funding: European Society of Anaesthesiology.-
dc.languageeng-
dc.relation.ispartofThe Lancet Respiratory Medicine-
dc.titlePost-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S2213-2600(18)30294-7-
dc.identifier.pmid30224322-
dc.identifier.scopuseid_2-s2.0-85060297287-
dc.identifier.volume7-
dc.identifier.issue2-
dc.identifier.spage129-
dc.identifier.epage140-
dc.identifier.eissn2213-2619-
dc.identifier.isiWOS:000457172000023-
dc.identifier.f1000734035849-
dc.identifier.issnl2213-2600-

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