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Article: Randomized controlled trial of TDCS on cognition in 201 seniors with mild neurocognitive disorder
Title | Randomized controlled trial of TDCS on cognition in 201 seniors with mild neurocognitive disorder |
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Authors | |
Keywords | Brain Prefrontal Cortex Anodal transcranial |
Issue Date | 2019 |
Publisher | Wiley Open Access: Creative Commons Attribution Non-Commercial No Derivatives. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2328-9503 |
Citation | Annals of Clinical and Translational Neurology, 2019, v. 6 n. 10, p. 1938-1948 How to Cite? |
Abstract | Objective:
To examine the efficacy and safety of combined transcranial direct current stimulation (tDCS) and working memory training (WMT) in enhancing the cognitive functions for individuals with mild neurocognitive disorder due to AD (NCD‐AD).
Methods:
In this double‐blind, sham‐controlled randomized clinical trial (RCT), 201 patients with NCD‐AD were randomly assigned for a 4‐week intervention of either a combination of tDCS and WMT, sham tDCS and WMT, or tDCS and control cognitive training (CCT). Global cognition and domain‐specific cognitive function were assessed before and after the intervention with Alzheimer's disease assessment scale‐cognitive subscale (ADAS‐Cog), category verbal fluency test, logical memory, digit, and visual span tests.
Results:
Study participants did not show intervention group differences in baseline demographics, or cognitive characteristics (ANOVA). Cognitive enhancement was found across three groups after 4 weeks intervention. Combined tDCS‐WMT group showed significantly greater improvement compared with single‐modality groups in delayed recall (P = 0.043, η2 = 0.036) and working memory capacity (P = 0.04, η2 = 0.038) at 4th week, and logical memory at 12th week (P = 0.042, η2 = 0.037). Adverse events, including skin lesions (2.2%), were similar between groups.
Interpretation:
tDCS or WMT could be a safe, feasible, and effective intervention for individuals with NCD‐AD. A combination of tDCS and WMT presents greater cognitive enhancement, which may highlight the potential synergistic effects of combined modality intervention on cognition. |
Persistent Identifier | http://hdl.handle.net/10722/279197 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 1.695 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lu, H | - |
dc.contributor.author | Chan, SSM | - |
dc.contributor.author | Chan, WC | - |
dc.contributor.author | Lin, C | - |
dc.contributor.author | Cheng, CPW | - |
dc.contributor.author | Lam, LCW | - |
dc.date.accessioned | 2019-10-21T02:21:23Z | - |
dc.date.available | 2019-10-21T02:21:23Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Annals of Clinical and Translational Neurology, 2019, v. 6 n. 10, p. 1938-1948 | - |
dc.identifier.issn | 2328-9503 | - |
dc.identifier.uri | http://hdl.handle.net/10722/279197 | - |
dc.description.abstract | Objective: To examine the efficacy and safety of combined transcranial direct current stimulation (tDCS) and working memory training (WMT) in enhancing the cognitive functions for individuals with mild neurocognitive disorder due to AD (NCD‐AD). Methods: In this double‐blind, sham‐controlled randomized clinical trial (RCT), 201 patients with NCD‐AD were randomly assigned for a 4‐week intervention of either a combination of tDCS and WMT, sham tDCS and WMT, or tDCS and control cognitive training (CCT). Global cognition and domain‐specific cognitive function were assessed before and after the intervention with Alzheimer's disease assessment scale‐cognitive subscale (ADAS‐Cog), category verbal fluency test, logical memory, digit, and visual span tests. Results: Study participants did not show intervention group differences in baseline demographics, or cognitive characteristics (ANOVA). Cognitive enhancement was found across three groups after 4 weeks intervention. Combined tDCS‐WMT group showed significantly greater improvement compared with single‐modality groups in delayed recall (P = 0.043, η2 = 0.036) and working memory capacity (P = 0.04, η2 = 0.038) at 4th week, and logical memory at 12th week (P = 0.042, η2 = 0.037). Adverse events, including skin lesions (2.2%), were similar between groups. Interpretation: tDCS or WMT could be a safe, feasible, and effective intervention for individuals with NCD‐AD. A combination of tDCS and WMT presents greater cognitive enhancement, which may highlight the potential synergistic effects of combined modality intervention on cognition. | - |
dc.language | eng | - |
dc.publisher | Wiley Open Access: Creative Commons Attribution Non-Commercial No Derivatives. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2328-9503 | - |
dc.relation.ispartof | Annals of Clinical and Translational Neurology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Brain | - |
dc.subject | Prefrontal Cortex | - |
dc.subject | Anodal transcranial | - |
dc.title | Randomized controlled trial of TDCS on cognition in 201 seniors with mild neurocognitive disorder | - |
dc.type | Article | - |
dc.identifier.email | Chan, WC: waicchan@hku.hk | - |
dc.identifier.email | Cheng, CPW: chengpsy@hku.hk | - |
dc.identifier.authority | Chan, WC=rp01687 | - |
dc.identifier.authority | Cheng, CPW=rp02333 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1002/acn3.50823 | - |
dc.identifier.pmid | 31529691 | - |
dc.identifier.pmcid | PMC6801176 | - |
dc.identifier.scopus | eid_2-s2.0-85073597105 | - |
dc.identifier.hkuros | 308002 | - |
dc.identifier.volume | 6 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 1938 | - |
dc.identifier.epage | 1948 | - |
dc.identifier.isi | WOS:000486935000001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2328-9503 | - |