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- Publisher Website: 10.1007/s10735-018-9788-x
- Scopus: eid_2-s2.0-85052058220
- PMID: 30066216
- WOS: WOS:000445760300005
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Article: Constitutive activation of β-catenin in ameloblasts leads to incisor enamel hypomineralization
Title | Constitutive activation of β-catenin in ameloblasts leads to incisor enamel hypomineralization |
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Authors | |
Keywords | β-Catenin Ameloblast Enamel Hypomineralization |
Issue Date | 2018 |
Publisher | Springer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1567-2379 |
Citation | Journal of Molecular Histology, 2018, v. 49 n. 5, p. 499-507 How to Cite? |
Abstract | Enamel is the hardest tissue with the highest degree of mineralization protecting the dental pulp from injury in vertebrates. The ameloblasts differentiated from ectoderm-derived epithelial cells are a single cell layer and are important for the enamel formation and mineralization. Wnt/β-catenin signaling has been proven to exert an important role in the mineralization of bone, dentin and cementum. Little was known about the regulatory mechanism of Wnt/β-catenin signaling pathway in ameloblasts during amelogenesis, especially in the mineralization of enamel. To investigate the role of β-catenin in ameloblasts, we established Amelx-Cre; β-catenin∆ex3fl/fl (CA-β-catenin) mice, which could constitutive activate β-catenin in ameloblasts. It showed the delayed mineralization and eventual hypomineralization in the incisor enamel of CA-β-catenin mice. Meanwhile, the amelogenesis-related proteinases Mmp20 and Klk4 were decreased in the incisors of CA-β-catenin mice. These data indicated that β-catenin plays an essential role in differentiation and function of ameloblasts during amelogenesis. |
Persistent Identifier | http://hdl.handle.net/10722/279122 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.784 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Fan, L | - |
dc.contributor.author | Deng, S | - |
dc.contributor.author | Sui, X | - |
dc.contributor.author | Liu, M | - |
dc.contributor.author | Cheng, S | - |
dc.contributor.author | Wang, Y | - |
dc.contributor.author | Gao, Y | - |
dc.contributor.author | Chu, CH | - |
dc.contributor.author | Zhang, Q | - |
dc.date.accessioned | 2019-10-21T02:19:58Z | - |
dc.date.available | 2019-10-21T02:19:58Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Journal of Molecular Histology, 2018, v. 49 n. 5, p. 499-507 | - |
dc.identifier.issn | 1567-2379 | - |
dc.identifier.uri | http://hdl.handle.net/10722/279122 | - |
dc.description.abstract | Enamel is the hardest tissue with the highest degree of mineralization protecting the dental pulp from injury in vertebrates. The ameloblasts differentiated from ectoderm-derived epithelial cells are a single cell layer and are important for the enamel formation and mineralization. Wnt/β-catenin signaling has been proven to exert an important role in the mineralization of bone, dentin and cementum. Little was known about the regulatory mechanism of Wnt/β-catenin signaling pathway in ameloblasts during amelogenesis, especially in the mineralization of enamel. To investigate the role of β-catenin in ameloblasts, we established Amelx-Cre; β-catenin∆ex3fl/fl (CA-β-catenin) mice, which could constitutive activate β-catenin in ameloblasts. It showed the delayed mineralization and eventual hypomineralization in the incisor enamel of CA-β-catenin mice. Meanwhile, the amelogenesis-related proteinases Mmp20 and Klk4 were decreased in the incisors of CA-β-catenin mice. These data indicated that β-catenin plays an essential role in differentiation and function of ameloblasts during amelogenesis. | - |
dc.language | eng | - |
dc.publisher | Springer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1567-2379 | - |
dc.relation.ispartof | Journal of Molecular Histology | - |
dc.subject | β-Catenin | - |
dc.subject | Ameloblast | - |
dc.subject | Enamel | - |
dc.subject | Hypomineralization | - |
dc.title | Constitutive activation of β-catenin in ameloblasts leads to incisor enamel hypomineralization | - |
dc.type | Article | - |
dc.identifier.email | Chu, CH: chchu@hku.hk | - |
dc.identifier.authority | Chu, CH=rp00022 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s10735-018-9788-x | - |
dc.identifier.pmid | 30066216 | - |
dc.identifier.scopus | eid_2-s2.0-85052058220 | - |
dc.identifier.hkuros | 307234 | - |
dc.identifier.volume | 49 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 499 | - |
dc.identifier.epage | 507 | - |
dc.identifier.isi | WOS:000445760300005 | - |
dc.publisher.place | Netherlands | - |
dc.identifier.issnl | 1567-2379 | - |