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- Publisher Website: 10.1021/acsami.8b08606
- Scopus: eid_2-s2.0-85049247857
- PMID: 29939711
- WOS: WOS:000439528400031
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Article: Bone Targeted Delivery of SDF-1 via Alendronate Functionalized Nanoparticles in Guiding Stem Cell Migration
| Title | Bone Targeted Delivery of SDF-1 via Alendronate Functionalized Nanoparticles in Guiding Stem Cell Migration |
|---|---|
| Authors | |
| Keywords | bone targeting gene delivery stem cell homing SDF-1 osteoporosis therapy |
| Issue Date | 2018 |
| Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/aamick |
| Citation | ACS Applied Materials & Interfaces, 2018, v. 10 n. 28, p. 23700-23710 How to Cite? |
| Abstract | Stem cells are well-known for their great capacity for tissue regeneration. This provides a promising source for cell-based therapies in treating various bone degenerative disorders. However, the major hurdles for their application in transplantation are the poor bone marrow homing and engraftment efficiencies. Stromal cell-derived factor 1 (SDF-1) has been identified as a major stem cell homing factor. With the aims of bone targeted SDF-1 delivery and regulating MSCs migration, alendronate modified liposomal nanoparticles (Aln-Lipo) carrying SDF-1 gene were developed in this study. Alendronate modification significantly increased the mineral binding affinity of liposomes, and facilitated the gene delivery to osteoblastic cells. Up-regulated SDF-1 expression in osteoblasts triggered MSCs migration. Systemic infusion of Aln-Lipo-SDF-1 with fluorescence labeling in mice showed the accumulation in osseous tissue by biophotonic imaging. Corresponding to the delivered SDF-1, the transplanted GFP+ MSCs were attracted to bone marrow and contributed to bone regeneration. This study may provide a useful technique in regulating stem cell migration. |
| Persistent Identifier | http://hdl.handle.net/10722/278942 |
| ISSN | 2021 Impact Factor: 10.383 2020 SCImago Journal Rankings: 2.535 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | CHEN, Q | - |
| dc.contributor.author | ZHENG, C | - |
| dc.contributor.author | LI, Y | - |
| dc.contributor.author | BIAN, S | - |
| dc.contributor.author | PAN, H | - |
| dc.contributor.author | ZHAO, X | - |
| dc.contributor.author | Lu, WW | - |
| dc.date.accessioned | 2019-10-21T02:16:46Z | - |
| dc.date.available | 2019-10-21T02:16:46Z | - |
| dc.date.issued | 2018 | - |
| dc.identifier.citation | ACS Applied Materials & Interfaces, 2018, v. 10 n. 28, p. 23700-23710 | - |
| dc.identifier.issn | 1944-8244 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/278942 | - |
| dc.description.abstract | Stem cells are well-known for their great capacity for tissue regeneration. This provides a promising source for cell-based therapies in treating various bone degenerative disorders. However, the major hurdles for their application in transplantation are the poor bone marrow homing and engraftment efficiencies. Stromal cell-derived factor 1 (SDF-1) has been identified as a major stem cell homing factor. With the aims of bone targeted SDF-1 delivery and regulating MSCs migration, alendronate modified liposomal nanoparticles (Aln-Lipo) carrying SDF-1 gene were developed in this study. Alendronate modification significantly increased the mineral binding affinity of liposomes, and facilitated the gene delivery to osteoblastic cells. Up-regulated SDF-1 expression in osteoblasts triggered MSCs migration. Systemic infusion of Aln-Lipo-SDF-1 with fluorescence labeling in mice showed the accumulation in osseous tissue by biophotonic imaging. Corresponding to the delivered SDF-1, the transplanted GFP+ MSCs were attracted to bone marrow and contributed to bone regeneration. This study may provide a useful technique in regulating stem cell migration. | - |
| dc.language | eng | - |
| dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/aamick | - |
| dc.relation.ispartof | ACS Applied Materials & Interfaces | - |
| dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html]. | - |
| dc.subject | bone targeting | - |
| dc.subject | gene delivery | - |
| dc.subject | stem cell homing | - |
| dc.subject | SDF-1 | - |
| dc.subject | osteoporosis therapy | - |
| dc.title | Bone Targeted Delivery of SDF-1 via Alendronate Functionalized Nanoparticles in Guiding Stem Cell Migration | - |
| dc.type | Article | - |
| dc.identifier.email | Lu, WW: wwlu@hku.hk | - |
| dc.identifier.authority | Lu, WW=rp00411 | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1021/acsami.8b08606 | - |
| dc.identifier.pmid | 29939711 | - |
| dc.identifier.scopus | eid_2-s2.0-85049247857 | - |
| dc.identifier.hkuros | 307541 | - |
| dc.identifier.volume | 10 | - |
| dc.identifier.issue | 28 | - |
| dc.identifier.spage | 23700 | - |
| dc.identifier.epage | 23710 | - |
| dc.identifier.isi | WOS:000439528400031 | - |
| dc.publisher.place | United States | - |
| dc.identifier.issnl | 1944-8244 | - |