File Download
There are no files associated with this item.
Supplementary
-
Citations:
- Appears in Collections:
Conference Paper: Role of periapical diseases in development of medication-related osteonecrosis of the jaw
Title | Role of periapical diseases in development of medication-related osteonecrosis of the jaw |
---|---|
Authors | |
Issue Date | 2018 |
Publisher | European Association of Oral Medicine. |
Citation | 14th Biennial Congress of the European Association of Oral Medicine (EAOM) in conjunction with the World Workshop VII on Oral Medicine, Göteborg, Sweden, 27-29 September 2018 How to Cite? |
Abstract | Objectives: This study aimed to assess the effect of zoledronic acid on the development of medication-related osteonecrosis of the jaw (MRONJ) using an immunocompromised mice model with periapical disease.
Materials and Methods: Thirty C57BL/6N mice were randomly divided into three groups (N=10). All animals were subjected to bilateral ovariectomy and then treated with saline (Veh), zoledronic acid (ZA) or concomitant zoledronic acid and dexamethasone (ZA/Dx) for 12 weeks. Eight weeks after starting drug administration, pulpal exposure was conducted on the lower left first molar. Four weeks after pulpal exposure, all mice were sacrificed, and the mandibles were collected for radiological and histological examinations.
Results: Micro computed tomography (μ-CT) examination showed significantly reduced periapical bone resorption in ZA/Dx group and decreased periodontal bone resorption in both ZA and ZA/Dx groups. Higher bone mineral density and strengthened microstructure were found in ZA and ZA/Dx groups. More empty lacunae were found in ZA and ZA/Dx groups.
Conclusions: Apical periodontitis aggravates MRONJ under immunocompromised circumstances. Concurrent use of ZA and steroids inhibits alveolar bone resorption but increases the risk of developing MRONJ. |
Description | Poster Presentation - no. Sat-07 |
Persistent Identifier | http://hdl.handle.net/10722/278324 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rao, N | - |
dc.contributor.author | Zheng, L | - |
dc.date.accessioned | 2019-10-04T08:11:48Z | - |
dc.date.available | 2019-10-04T08:11:48Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | 14th Biennial Congress of the European Association of Oral Medicine (EAOM) in conjunction with the World Workshop VII on Oral Medicine, Göteborg, Sweden, 27-29 September 2018 | - |
dc.identifier.uri | http://hdl.handle.net/10722/278324 | - |
dc.description | Poster Presentation - no. Sat-07 | - |
dc.description.abstract | Objectives: This study aimed to assess the effect of zoledronic acid on the development of medication-related osteonecrosis of the jaw (MRONJ) using an immunocompromised mice model with periapical disease. Materials and Methods: Thirty C57BL/6N mice were randomly divided into three groups (N=10). All animals were subjected to bilateral ovariectomy and then treated with saline (Veh), zoledronic acid (ZA) or concomitant zoledronic acid and dexamethasone (ZA/Dx) for 12 weeks. Eight weeks after starting drug administration, pulpal exposure was conducted on the lower left first molar. Four weeks after pulpal exposure, all mice were sacrificed, and the mandibles were collected for radiological and histological examinations. Results: Micro computed tomography (μ-CT) examination showed significantly reduced periapical bone resorption in ZA/Dx group and decreased periodontal bone resorption in both ZA and ZA/Dx groups. Higher bone mineral density and strengthened microstructure were found in ZA and ZA/Dx groups. More empty lacunae were found in ZA and ZA/Dx groups. Conclusions: Apical periodontitis aggravates MRONJ under immunocompromised circumstances. Concurrent use of ZA and steroids inhibits alveolar bone resorption but increases the risk of developing MRONJ. | - |
dc.language | eng | - |
dc.publisher | European Association of Oral Medicine. | - |
dc.relation.ispartof | 14th Biennial Congress of the European Association of Oral Medicine (EAOM), in conjunction with the World Workshop on Oral Medicine VII | - |
dc.title | Role of periapical diseases in development of medication-related osteonecrosis of the jaw | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Zheng, L: lwzheng@hkucc.hku.hk | - |
dc.identifier.authority | Zheng, L=rp01411 | - |
dc.identifier.hkuros | 307020 | - |
dc.publisher.place | Sweden | - |