File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.7150/ijbs.34785
- Scopus: eid_2-s2.0-85070992520
- PMID: 31523184
- WOS: WOS:000481578100003
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: CHL1 suppresses tumor growth and metastasis in nasopharyngeal carcinoma by repressing PI3K/AKT signaling pathway via interaction with Integrin β1 and Merlin
Title | CHL1 suppresses tumor growth and metastasis in nasopharyngeal carcinoma by repressing PI3K/AKT signaling pathway via interaction with Integrin β1 and Merlin |
---|---|
Authors | |
Keywords | nasopharyngeal carcinoma tumor suppressor gene tumor invasion tumor metastasis |
Issue Date | 2019 |
Publisher | Ivyspring International Publisher. The Journal's web site is located at http://www.biolsci.org/index.htm |
Citation | International Journal of Biological Sciences, 2019, v. 15 n. 9, p. 1802-1815 How to Cite? |
Abstract | Deletion of Chromosome 3p is one of the most frequently detected genetic alterations in nasopharyngeal carcinoma (NPC). We reported the role of a novel 3p26.3 tumor suppressor gene (TSG) CHL1 in NPC. Down-regulation of CHL1 was detected in 4/6 of NPC cell lines and 71/95 (74.7%) in clinical tissues. Ectopic expressions of CHL1 in NPC cells significantly inhibit colony formation and cell motility in functional study. By up-regulating epithelial markers and down-regulating mesenchymal markers CHL1 could induce mesenchymal-epithelial transition (MET), a key step in preventing tumor invasion and metastasis. CHL1 could also cause the inactivation of RhoA/Rac1/Cdc42 signaling pathway and inhibit the formation of stress fiber, lamellipodia, and filopodia. CHL1 could co-localize with adhesion molecule Integrin-β1, the expression of CHL1 was positively correlated with Integrin-β1 and another known tumor suppressor gene (TSG) Merlin. Down-regulation of Integrin-β1 or Merlin was significantly correlated with the poor survival rate of NPC patients. Further mechanistic studies showed that CHL1 could directly interact with integrin-β1 and link to Merlin, leading to the inactivation of integrin β1-AKT pathway. In conclusion, CHL1 is a vital tumor suppressor in the carcinogenesis of NPC. |
Persistent Identifier | http://hdl.handle.net/10722/278066 |
ISSN | 2023 Impact Factor: 8.2 2023 SCImago Journal Rankings: 2.114 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, J | - |
dc.contributor.author | JIANG, C | - |
dc.contributor.author | Fu, L | - |
dc.contributor.author | Zhu, C-L | - |
dc.contributor.author | Xiang, Y-Q | - |
dc.contributor.author | Jiang, L-X | - |
dc.contributor.author | Chen, Q | - |
dc.contributor.author | Lin, WM | - |
dc.contributor.author | CHEN, J-N | - |
dc.contributor.author | Zhang, L-Y | - |
dc.contributor.author | Liu, M | - |
dc.contributor.author | Chen, C | - |
dc.contributor.author | Tang, H | - |
dc.contributor.author | Wang, B | - |
dc.contributor.author | Tsao, SW | - |
dc.contributor.author | Kwong, DLW | - |
dc.contributor.author | Guan, X | - |
dc.date.accessioned | 2019-10-04T08:06:51Z | - |
dc.date.available | 2019-10-04T08:06:51Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | International Journal of Biological Sciences, 2019, v. 15 n. 9, p. 1802-1815 | - |
dc.identifier.issn | 1449-2288 | - |
dc.identifier.uri | http://hdl.handle.net/10722/278066 | - |
dc.description.abstract | Deletion of Chromosome 3p is one of the most frequently detected genetic alterations in nasopharyngeal carcinoma (NPC). We reported the role of a novel 3p26.3 tumor suppressor gene (TSG) CHL1 in NPC. Down-regulation of CHL1 was detected in 4/6 of NPC cell lines and 71/95 (74.7%) in clinical tissues. Ectopic expressions of CHL1 in NPC cells significantly inhibit colony formation and cell motility in functional study. By up-regulating epithelial markers and down-regulating mesenchymal markers CHL1 could induce mesenchymal-epithelial transition (MET), a key step in preventing tumor invasion and metastasis. CHL1 could also cause the inactivation of RhoA/Rac1/Cdc42 signaling pathway and inhibit the formation of stress fiber, lamellipodia, and filopodia. CHL1 could co-localize with adhesion molecule Integrin-β1, the expression of CHL1 was positively correlated with Integrin-β1 and another known tumor suppressor gene (TSG) Merlin. Down-regulation of Integrin-β1 or Merlin was significantly correlated with the poor survival rate of NPC patients. Further mechanistic studies showed that CHL1 could directly interact with integrin-β1 and link to Merlin, leading to the inactivation of integrin β1-AKT pathway. In conclusion, CHL1 is a vital tumor suppressor in the carcinogenesis of NPC. | - |
dc.language | eng | - |
dc.publisher | Ivyspring International Publisher. The Journal's web site is located at http://www.biolsci.org/index.htm | - |
dc.relation.ispartof | International Journal of Biological Sciences | - |
dc.rights | International Journal of Biological Sciences. Copyright © Ivyspring International Publisher. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | nasopharyngeal carcinoma | - |
dc.subject | tumor suppressor gene | - |
dc.subject | tumor invasion | - |
dc.subject | tumor metastasis | - |
dc.title | CHL1 suppresses tumor growth and metastasis in nasopharyngeal carcinoma by repressing PI3K/AKT signaling pathway via interaction with Integrin β1 and Merlin | - |
dc.type | Article | - |
dc.identifier.email | Tsao, SW: gswtsao@hku.hk | - |
dc.identifier.email | Kwong, DLW: dlwkwong@hku.hk | - |
dc.identifier.email | Guan, X: xyguan@hku.hk | - |
dc.identifier.authority | Tsao, SW=rp00399 | - |
dc.identifier.authority | Kwong, DLW=rp00414 | - |
dc.identifier.authority | Guan, X=rp00454 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.7150/ijbs.34785 | - |
dc.identifier.pmid | 31523184 | - |
dc.identifier.pmcid | PMC6743306 | - |
dc.identifier.scopus | eid_2-s2.0-85070992520 | - |
dc.identifier.hkuros | 306348 | - |
dc.identifier.volume | 15 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 1802 | - |
dc.identifier.epage | 1815 | - |
dc.identifier.isi | WOS:000481578100003 | - |
dc.publisher.place | Australia | - |
dc.identifier.issnl | 1449-2288 | - |