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Article: The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation
Title | The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation |
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Authors | |
Keywords | DNA methylation DNMT1 UHRF1 USP7 ubiquitination |
Issue Date | 2018 |
Publisher | MDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/genes |
Citation | Genes, 2018, v. 9 n. 12, p. 600 How to Cite? |
Abstract | Mammalian DNMT1 is mainly responsible for maintenance DNA methylation that is critical in maintaining stem cell pluripotency and controlling lineage specification during early embryonic development. A number of studies have demonstrated that DNMT1 is an auto-inhibited enzyme and its enzymatic activity is allosterically regulated by a number of interacting partners. UHRF1 has previously been reported to regulate DNMT1 in multiple ways, including control of substrate specificity and the proper genome targeting. In this review, we discuss the recent advances in our understanding of the regulation of DNMT1 enzymatic activity by UHRF1 and highlight a number of unresolved questions. |
Persistent Identifier | http://hdl.handle.net/10722/278062 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.817 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xie, S | - |
dc.contributor.author | Qian, C | - |
dc.date.accessioned | 2019-10-04T08:06:46Z | - |
dc.date.available | 2019-10-04T08:06:46Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Genes, 2018, v. 9 n. 12, p. 600 | - |
dc.identifier.issn | 2073-4425 | - |
dc.identifier.uri | http://hdl.handle.net/10722/278062 | - |
dc.description.abstract | Mammalian DNMT1 is mainly responsible for maintenance DNA methylation that is critical in maintaining stem cell pluripotency and controlling lineage specification during early embryonic development. A number of studies have demonstrated that DNMT1 is an auto-inhibited enzyme and its enzymatic activity is allosterically regulated by a number of interacting partners. UHRF1 has previously been reported to regulate DNMT1 in multiple ways, including control of substrate specificity and the proper genome targeting. In this review, we discuss the recent advances in our understanding of the regulation of DNMT1 enzymatic activity by UHRF1 and highlight a number of unresolved questions. | - |
dc.language | eng | - |
dc.publisher | MDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/genes | - |
dc.relation.ispartof | Genes | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | DNA methylation | - |
dc.subject | DNMT1 | - |
dc.subject | UHRF1 | - |
dc.subject | USP7 | - |
dc.subject | ubiquitination | - |
dc.title | The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation | - |
dc.type | Article | - |
dc.identifier.email | Xie, S: xiesi@hku.hk | - |
dc.identifier.email | Qian, C: cmqian@hku.hk | - |
dc.identifier.authority | Qian, C=rp01371 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/genes9120600 | - |
dc.identifier.scopus | eid_2-s2.0-85058512224 | - |
dc.identifier.hkuros | 306092 | - |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 600 | - |
dc.identifier.epage | 600 | - |
dc.identifier.isi | WOS:000454717800034 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 2073-4425 | - |