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- Publisher Website: 10.1124/pr.118.017178
- Scopus: eid_2-s2.0-85072662034
- PMID: 31554644
- WOS: WOS:000500540700007
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Article: Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products
Title | Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products |
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Authors | |
Keywords | animal model arteriosclerosis atherosclerosis cholesterol transport cholesterol esterification |
Issue Date | 2019 |
Publisher | American Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://www.pharmrev.org/ |
Citation | Pharmacological Reviews, 2019, v. 71 n. 4, p. 596-670 How to Cite? |
Abstract | Foam cell formation and further accumulation in the subendothelial space of the vascular wall is a hallmark of atherosclerotic lesions. Targeting foam cell formation in the atherosclerotic lesions can be a promising approach to treat and prevent atherosclerosis. The formation of foam cells is determined by the balanced effects of three major interrelated biologic processes, including lipid uptake, cholesterol esterification, and cholesterol efflux. Natural products are a promising source for new lead structures. Multiple natural products and pharmaceutical agents can inhibit foam cell formation and thus exhibit antiatherosclerotic capacity by suppressing lipid uptake, cholesterol esterification, and/or promoting cholesterol ester hydrolysis and cholesterol efflux. This review summarizes recent findings on these three biologic processes and natural products with demonstrated potential to target such processes. Discussed also are potential future directions for studying the mechanisms of foam cell formation and the development of foam cell-targeted therapeutic strategies. |
Persistent Identifier | http://hdl.handle.net/10722/277731 |
ISSN | 2023 Impact Factor: 19.3 2023 SCImago Journal Rankings: 6.050 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, D | - |
dc.contributor.author | Yang, Y | - |
dc.contributor.author | Lei, Y | - |
dc.contributor.author | Tzvetkov, NT | - |
dc.contributor.author | Liu, X | - |
dc.contributor.author | Yeung, AWK | - |
dc.contributor.author | Xu, S | - |
dc.contributor.author | Atanasov, AG | - |
dc.date.accessioned | 2019-10-04T08:00:11Z | - |
dc.date.available | 2019-10-04T08:00:11Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Pharmacological Reviews, 2019, v. 71 n. 4, p. 596-670 | - |
dc.identifier.issn | 0031-6997 | - |
dc.identifier.uri | http://hdl.handle.net/10722/277731 | - |
dc.description.abstract | Foam cell formation and further accumulation in the subendothelial space of the vascular wall is a hallmark of atherosclerotic lesions. Targeting foam cell formation in the atherosclerotic lesions can be a promising approach to treat and prevent atherosclerosis. The formation of foam cells is determined by the balanced effects of three major interrelated biologic processes, including lipid uptake, cholesterol esterification, and cholesterol efflux. Natural products are a promising source for new lead structures. Multiple natural products and pharmaceutical agents can inhibit foam cell formation and thus exhibit antiatherosclerotic capacity by suppressing lipid uptake, cholesterol esterification, and/or promoting cholesterol ester hydrolysis and cholesterol efflux. This review summarizes recent findings on these three biologic processes and natural products with demonstrated potential to target such processes. Discussed also are potential future directions for studying the mechanisms of foam cell formation and the development of foam cell-targeted therapeutic strategies. | - |
dc.language | eng | - |
dc.publisher | American Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://www.pharmrev.org/ | - |
dc.relation.ispartof | Pharmacological Reviews | - |
dc.subject | animal model | - |
dc.subject | arteriosclerosis | - |
dc.subject | atherosclerosis | - |
dc.subject | cholesterol transport | - |
dc.subject | cholesterol esterification | - |
dc.title | Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products | - |
dc.type | Article | - |
dc.identifier.email | Yeung, AWK: ndyeung@hku.hk | - |
dc.identifier.authority | Yeung, AWK=rp02143 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1124/pr.118.017178 | - |
dc.identifier.pmid | 31554644 | - |
dc.identifier.scopus | eid_2-s2.0-85072662034 | - |
dc.identifier.hkuros | 306843 | - |
dc.identifier.volume | 71 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 596 | - |
dc.identifier.epage | 670 | - |
dc.identifier.isi | WOS:000500540700007 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0031-6997 | - |