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Article: Effects of Lactobacillus rhamnosus GG and Escherichia coli Nissle 1917 cell-free supernatants on modulation of mucin and cytokine secretion on Human Intestinal Epithelial HT29‐MTX Cells

TitleEffects of Lactobacillus rhamnosus GG and Escherichia coli Nissle 1917 cell-free supernatants on modulation of mucin and cytokine secretion on Human Intestinal Epithelial HT29‐MTX Cells
Authors
Keywordscytokine
Escherichia coli Nissle 1917
intestinal immune response
Lactobacillus rhamnosus GG
mucins
Issue Date2018
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-1147
Citation
Journal of Food Science, 2018, v. 83 n. 7, p. 1999-2007 How to Cite?
AbstractThis study examined modulation effects of cell‐free supernatants of two commonly studied probiotic bacteria Lactobacillus rhamnosus GG (LGG) and Escherichia coli Nissle 1917 (EcN) on mucin and cytokine profiles of human intestinal epithelial HT29‐MTX cells. It was found that LGG and EcN supernatants differentially modulated MUC5AC and MUC5B mRNA and protein, and total mucin‐like glycoprotein secretion. Regarding modulation of cytokine profiles, LGG supernatants moderately influenced the secretion of anti‐inflammatory cytokines such as interleukin (IL)‐4, IL‐5, and IL‐10, while those of EcN exerted a broad proinflammatory effect to intestinal epithelial cells by inducing the secretion of proinflammatory cytokines such as IL‐8, monocyte chemotactic protein‐1, transforming growth factor α, tumor necrosis factor α, granulocyte macrophage colony‐stimulating factor, and interferon γ. These results suggested that LGG and EcN might produce different bioactive products that display differential modulation of mucin and cytokines, which may contribute to intestinal health and/or defense against bacteria/pathogens. Practical Application: The results suggested that LGG and EcN might produce different bioactive products that display differential modulation of mucin and cytokines, which may contribute to intestinal health and/or defense against bacteria/pathogens.
Persistent Identifierhttp://hdl.handle.net/10722/277398
ISSN
2020 Impact Factor: 3.167
2020 SCImago Journal Rankings: 0.772
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWAN, MLY-
dc.contributor.authorChen, Z-
dc.contributor.authorShah, NPS-
dc.contributor.authorEl-Nezami, H-
dc.date.accessioned2019-09-20T08:50:19Z-
dc.date.available2019-09-20T08:50:19Z-
dc.date.issued2018-
dc.identifier.citationJournal of Food Science, 2018, v. 83 n. 7, p. 1999-2007-
dc.identifier.issn0022-1147-
dc.identifier.urihttp://hdl.handle.net/10722/277398-
dc.description.abstractThis study examined modulation effects of cell‐free supernatants of two commonly studied probiotic bacteria Lactobacillus rhamnosus GG (LGG) and Escherichia coli Nissle 1917 (EcN) on mucin and cytokine profiles of human intestinal epithelial HT29‐MTX cells. It was found that LGG and EcN supernatants differentially modulated MUC5AC and MUC5B mRNA and protein, and total mucin‐like glycoprotein secretion. Regarding modulation of cytokine profiles, LGG supernatants moderately influenced the secretion of anti‐inflammatory cytokines such as interleukin (IL)‐4, IL‐5, and IL‐10, while those of EcN exerted a broad proinflammatory effect to intestinal epithelial cells by inducing the secretion of proinflammatory cytokines such as IL‐8, monocyte chemotactic protein‐1, transforming growth factor α, tumor necrosis factor α, granulocyte macrophage colony‐stimulating factor, and interferon γ. These results suggested that LGG and EcN might produce different bioactive products that display differential modulation of mucin and cytokines, which may contribute to intestinal health and/or defense against bacteria/pathogens. Practical Application: The results suggested that LGG and EcN might produce different bioactive products that display differential modulation of mucin and cytokines, which may contribute to intestinal health and/or defense against bacteria/pathogens.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-1147-
dc.relation.ispartofJournal of Food Science-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectcytokine-
dc.subjectEscherichia coli Nissle 1917-
dc.subjectintestinal immune response-
dc.subjectLactobacillus rhamnosus GG-
dc.subjectmucins-
dc.titleEffects of Lactobacillus rhamnosus GG and Escherichia coli Nissle 1917 cell-free supernatants on modulation of mucin and cytokine secretion on Human Intestinal Epithelial HT29‐MTX Cells-
dc.typeArticle-
dc.identifier.emailChen, Z: fwmcheng@hku.hk-
dc.identifier.emailShah, NPS: npshah@hku.hk-
dc.identifier.emailEl-Nezami, H: elnezami@hkucc.hku.hk-
dc.identifier.authorityShah, NPS=rp01571-
dc.identifier.authorityEl-Nezami, H=rp00694-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/1750-3841.14168-
dc.identifier.pmid29863797-
dc.identifier.scopuseid_2-s2.0-85049835992-
dc.identifier.hkuros305753-
dc.identifier.volume83-
dc.identifier.issue7-
dc.identifier.spage1999-
dc.identifier.epage2007-
dc.identifier.isiWOS:000438216600028-
dc.publisher.placeUnited States-
dc.identifier.issnl0022-1147-

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