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Article: Spatio-temporal release of NGF and GDNF from multi-layered nanofibrous bicomponent electrospun scaffolds

TitleSpatio-temporal release of NGF and GDNF from multi-layered nanofibrous bicomponent electrospun scaffolds
Authors
KeywordsCell culture
Electrospinning
Emulsification
Fibers
Hydraulic structures
Issue Date2018
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530
Citation
Journal of Materials Science: Materials in Medicine, 2018, v. 29 n. 7, p. article no. 102 How to Cite?
AbstractScaffolds capable of providing dual neurotrophic factor (NTF) delivery with different release kinetics, spatial delivery of NTFs at different loci and topographical guidance are promising for enhanced peripheral nerve regeneration. In this study, we have designed and fabricated multi-layered aligned-fiber scaffolds through combining emulsion electrospinning, sequential electrospinning and high-speed electrospinning (HS-ES) to modulate the release behavior of glial cell line-derived growth factor(GDNF) and nerve growth factor (NGF). GDNF and NGF were incorporated into poly(lactic-co-glycolic acid) (PLGA) fibers and poly(D,L-lactic acid) (PDLLA) fibers, respectively. Aligned fibers were obtained in each layer of multi-layered scaffolds and relatively thick tri-layered and tetra-layered scaffolds with controlled layer thickness were obtained. Their morphology, structure, properties, and the in vitro release of growth factors were examined. Dual and spatio-temporal release of GDNF and NGF with different release kinetics from multi-layered scaffolds was successfully demonstrated. High separation efficiency by PDLLA fibrous barrier layer for spatial neurotrophic factor delivery from both tri-layered scaffolds and tetra-layered scaffolds was achieved.
Persistent Identifierhttp://hdl.handle.net/10722/277119
ISSN
2019 Impact Factor: 2.489
2013 SCImago Journal Rankings: 0.897
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, C-
dc.contributor.authorLi, X-
dc.contributor.authorXu, F-
dc.contributor.authorCong, H-
dc.contributor.authorLi, Z-
dc.contributor.authorSong, Y-
dc.contributor.authorWang, M-
dc.date.accessioned2019-09-20T08:44:49Z-
dc.date.available2019-09-20T08:44:49Z-
dc.date.issued2018-
dc.identifier.citationJournal of Materials Science: Materials in Medicine, 2018, v. 29 n. 7, p. article no. 102-
dc.identifier.issn0957-4530-
dc.identifier.urihttp://hdl.handle.net/10722/277119-
dc.description.abstractScaffolds capable of providing dual neurotrophic factor (NTF) delivery with different release kinetics, spatial delivery of NTFs at different loci and topographical guidance are promising for enhanced peripheral nerve regeneration. In this study, we have designed and fabricated multi-layered aligned-fiber scaffolds through combining emulsion electrospinning, sequential electrospinning and high-speed electrospinning (HS-ES) to modulate the release behavior of glial cell line-derived growth factor(GDNF) and nerve growth factor (NGF). GDNF and NGF were incorporated into poly(lactic-co-glycolic acid) (PLGA) fibers and poly(D,L-lactic acid) (PDLLA) fibers, respectively. Aligned fibers were obtained in each layer of multi-layered scaffolds and relatively thick tri-layered and tetra-layered scaffolds with controlled layer thickness were obtained. Their morphology, structure, properties, and the in vitro release of growth factors were examined. Dual and spatio-temporal release of GDNF and NGF with different release kinetics from multi-layered scaffolds was successfully demonstrated. High separation efficiency by PDLLA fibrous barrier layer for spatial neurotrophic factor delivery from both tri-layered scaffolds and tetra-layered scaffolds was achieved.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530-
dc.relation.ispartofJournal of Materials Science: Materials in Medicine-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: http://dx.doi.org/[insert DOI]-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCell culture-
dc.subjectElectrospinning-
dc.subjectEmulsification-
dc.subjectFibers-
dc.subjectHydraulic structures-
dc.titleSpatio-temporal release of NGF and GDNF from multi-layered nanofibrous bicomponent electrospun scaffolds-
dc.typeArticle-
dc.identifier.emailWang, M: memwang@hku.hk-
dc.identifier.authorityWang, M=rp00185-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1007/s10856-018-6105-x-
dc.identifier.pmid29955977-
dc.identifier.pmcidPMC6022522-
dc.identifier.scopuseid_2-s2.0-85049144851-
dc.identifier.hkuros305999-
dc.identifier.volume29-
dc.identifier.issue7-
dc.identifier.spagearticle no. 102-
dc.identifier.epagearticle no. 102-
dc.publisher.placeUnited States-

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