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- Publisher Website: 10.1021/ja800491v
- Scopus: eid_2-s2.0-67849122740
- PMID: 19146374
- WOS: WOS:000264792100002
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Article: Molecular glues carrying multiple guanidinium ion pendants via an oligoether spacer: Stabilization of microtubules against depolymerization
| Title | Molecular glues carrying multiple guanidinium ion pendants via an oligoether spacer: Stabilization of microtubules against depolymerization |
|---|---|
| Authors | |
| Issue Date | 2009 |
| Citation | Journal of the American Chemical Society, 2009, v. 131, n. 5, p. 1626-1627 How to Cite? |
| Abstract | Dendron G1(Gu+) |
| Persistent Identifier | http://hdl.handle.net/10722/276842 |
| ISSN | 2023 Impact Factor: 14.4 2023 SCImago Journal Rankings: 5.489 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Okuro, Kou | - |
| dc.contributor.author | Kinbara, Kazushi | - |
| dc.contributor.author | Tsumoto, Kouhei | - |
| dc.contributor.author | Lshii, Noriyuki | - |
| dc.contributor.author | Aida, Takuzo | - |
| dc.date.accessioned | 2019-09-18T08:34:49Z | - |
| dc.date.available | 2019-09-18T08:34:49Z | - |
| dc.date.issued | 2009 | - |
| dc.identifier.citation | Journal of the American Chemical Society, 2009, v. 131, n. 5, p. 1626-1627 | - |
| dc.identifier.issn | 0002-7863 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/276842 | - |
| dc.description.abstract | Dendron G1(Gu<sup>+</sup>)<inf>9</inf>R and linear peptide oligomer Asn(TEG-Gu<sup>+</sup>)<inf>9</inf>, decorated with multiple guanidinium (Gu<sup>+</sup>) ions as sticky pendants via an oligo(oxyethylene) spacer, adhere to BSA and protein assemblies such as microtubules in aqueous buffers. Using fluorescently labeled G1(Gu<sup>+</sup>)<inf>9</inf> with pyrenyl and rhodamine focal cores, the adhesion process can be visualized by FRET or confocal laser scanning microscopy. The adhesion to microtubules leads to their stabilization against depolymerization into α/βtubulin heterodimer components, where the effects of G1(Gu+)9R and Asn(TEG-Gu+)9 are comparable to that of paclitaxel, known as an anticancer drug. Since G1(Gu<sup>+</sup>) <inf>9</inf> and Asn(TEG-Gu<sup>+</sup>)<inf>9</inf> are superior to lower-generation G0(Gu<sup>+</sup>)<inf>3</inf>OMe and arginine nonamer, respectively, the multivalency of the interaction and a conformational flexibility of the oligoether spacers play a crucial role in the efficient adhesion to proteins. Copyright © 2009 American Chemical Society. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Journal of the American Chemical Society | - |
| dc.title | Molecular glues carrying multiple guanidinium ion pendants via an oligoether spacer: Stabilization of microtubules against depolymerization | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1021/ja800491v | - |
| dc.identifier.pmid | 19146374 | - |
| dc.identifier.scopus | eid_2-s2.0-67849122740 | - |
| dc.identifier.volume | 131 | - |
| dc.identifier.issue | 5 | - |
| dc.identifier.spage | 1626 | - |
| dc.identifier.epage | 1627 | - |
| dc.identifier.isi | WOS:000264792100002 | - |
| dc.identifier.issnl | 0002-7863 | - |