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Article: Reductively Cleavable Nanocaplets for siRNA Delivery by Template-Assisted Oxidative Polymerization

TitleReductively Cleavable Nanocaplets for siRNA Delivery by Template-Assisted Oxidative Polymerization
Authors
Hashim, P. K.Okuro, KouSasaki, ShigekazuHoashi, YasutakaAida, Takuzo
Issue Date2015
Citation
Journal of the American Chemical Society, 2015, v. 137, n. 50, p. 15608-15611 How to Cite?
DOI: http://dx.doi.org/10.1021/jacs.5b08948
Abstract© 2015 American Chemical Society. A series of water-soluble telechelic dithiol monomers bearing multiple guanidinium ion (Gu+) units in their main chains were synthesized for packaging siRNA by template-assisted oxidative polymerization at their thiol termini. In the presence of siRNA, oxidative polymerization of TEGGu4 affords a uniform-sized (7 ± 2 nm) nanocaplet containing siRNA (PTEGGu4siRNA; PTEGGu4 = polymerized TEGGu4). When this small conjugate is incubated with live cells, cellular uptake occurs, and the nanocaplet undergoes depolymerization in the reductive cytosolic environment to liberate the packaged siRNA. Consequently, gene expression in the live cells is suppressed.
Persistent Identifierhttp://hdl.handle.net/10722/276707
ISSN
0002-7863
2023 Impact Factor: 14.4
2023 SCImago Journal Rankings: 5.489
ISI Accession Number ID
WOS:000367562800004

 

DC FieldValueLanguage
dc.contributor.authorHashim, P. K.-
dc.contributor.authorOkuro, Kou-
dc.contributor.authorSasaki, Shigekazu-
dc.contributor.authorHoashi, Yasutaka-
dc.contributor.authorAida, Takuzo-
dc.date.accessioned2019-09-18T08:34:24Z-
dc.date.available2019-09-18T08:34:24Z-
dc.date.issued2015-
dc.identifier.citationJournal of the American Chemical Society, 2015, v. 137, n. 50, p. 15608-15611-
dc.identifier.issn0002-7863-
dc.identifier.urihttp://hdl.handle.net/10722/276707-
dc.description.abstract© 2015 American Chemical Society. A series of water-soluble telechelic dithiol monomers bearing multiple guanidinium ion (Gu+) units in their main chains were synthesized for packaging siRNA by template-assisted oxidative polymerization at their thiol termini. In the presence of siRNA, oxidative polymerization of TEGGu4 affords a uniform-sized (7 ± 2 nm) nanocaplet containing siRNA (PTEGGu4siRNA; PTEGGu4 = polymerized TEGGu4). When this small conjugate is incubated with live cells, cellular uptake occurs, and the nanocaplet undergoes depolymerization in the reductive cytosolic environment to liberate the packaged siRNA. Consequently, gene expression in the live cells is suppressed.-
dc.languageeng-
dc.relation.ispartofJournal of the American Chemical Society-
dc.titleReductively Cleavable Nanocaplets for siRNA Delivery by Template-Assisted Oxidative Polymerization-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/jacs.5b08948-
dc.identifier.pmid26648391-
dc.identifier.scopuseid_2-s2.0-84952837744-
dc.identifier.volume137-
dc.identifier.issue50-
dc.identifier.spage15608-
dc.identifier.epage15611-
dc.identifier.eissn1520-5126-
dc.identifier.isiWOS:000367562800004-
dc.identifier.issnl0002-7863-

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