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Article: Guanidinium-based "molecular glues" for modulation of biomolecular functions

TitleGuanidinium-based "molecular glues" for modulation of biomolecular functions
Authors
Issue Date2017
Citation
Chemical Society Reviews, 2017, v. 46, n. 21, p. 6480-6491 How to Cite?
Abstract© 2017 The Royal Society of Chemistry. Molecular adhesion based on multivalent interactions plays essential roles in various biological processes. Hence, "molecular glues" that can adhere to biomolecules may modulate biomolecular functions and therefore can be applied to therapeutics. This tutorial review describes design strategies for developing adhesive motifs for biomolecules based on multivalent interactions. We highlight a guanidinium ion-based salt-bridge as a key interaction for adhesion to biomolecules and discuss the application of molecular glues for manipulation of biomolecular assemblies, drug delivery systems, and modulation of biomolecular functions.
Persistent Identifierhttp://hdl.handle.net/10722/276557
ISSN
2023 Impact Factor: 40.4
2023 SCImago Journal Rankings: 12.511
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMogaki, Rina-
dc.contributor.authorHashim, P. K.-
dc.contributor.authorOkuro, Kou-
dc.contributor.authorAida, Takuzo-
dc.date.accessioned2019-09-18T08:33:58Z-
dc.date.available2019-09-18T08:33:58Z-
dc.date.issued2017-
dc.identifier.citationChemical Society Reviews, 2017, v. 46, n. 21, p. 6480-6491-
dc.identifier.issn0306-0012-
dc.identifier.urihttp://hdl.handle.net/10722/276557-
dc.description.abstract© 2017 The Royal Society of Chemistry. Molecular adhesion based on multivalent interactions plays essential roles in various biological processes. Hence, "molecular glues" that can adhere to biomolecules may modulate biomolecular functions and therefore can be applied to therapeutics. This tutorial review describes design strategies for developing adhesive motifs for biomolecules based on multivalent interactions. We highlight a guanidinium ion-based salt-bridge as a key interaction for adhesion to biomolecules and discuss the application of molecular glues for manipulation of biomolecular assemblies, drug delivery systems, and modulation of biomolecular functions.-
dc.languageeng-
dc.relation.ispartofChemical Society Reviews-
dc.titleGuanidinium-based "molecular glues" for modulation of biomolecular functions-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c7cs00647k-
dc.identifier.pmid29034942-
dc.identifier.scopuseid_2-s2.0-85032633739-
dc.identifier.volume46-
dc.identifier.issue21-
dc.identifier.spage6480-
dc.identifier.epage6491-
dc.identifier.eissn1460-4744-
dc.identifier.isiWOS:000413933800004-
dc.identifier.issnl0306-0012-

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