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- Publisher Website: 10.1002/anie.201502075
- Scopus: eid_2-s2.0-84930194013
- PMID: 25873526
- WOS: WOS:000355229800025
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Article: Palladium(0)/PAr3-catalyzed intermolecular amination of C(sp3)-H bonds: Synthesis of β-amino acids
| Title | Palladium(0)/PAr3-catalyzed intermolecular amination of C(sp3)-H bonds: Synthesis of β-amino acids |
|---|---|
| Authors | |
| Keywords | synthetic methods amination amino acids C-H activation palladium |
| Issue Date | 2015 |
| Citation | Angewandte Chemie - International Edition, 2015, v. 54, n. 22, p. 6545-6549 How to Cite? |
| Abstract | © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. An intermolecular C(sp3)-H amination using a Pd0/PAr3 catalyst was developed. The reaction begins with oxidative addition of R2N-OBz to a Pd0/PAr3 catalyst and subsequent cleavage of a C(sp3)-H bond by the generated Pd-NR2 intermediate. The catalytic cycle proceeds without the need for external oxidants in a similar manner to the extensively studied palladium(0)-catalyzed C-H arylation reactions. The electron-deficient triarylphosphine ligand is crucial for this C(sp3)-H amination reaction to occur. |
| Persistent Identifier | http://hdl.handle.net/10722/276494 |
| ISSN | 2023 Impact Factor: 16.1 2023 SCImago Journal Rankings: 5.300 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | He, Jian | - |
| dc.contributor.author | Shigenari, Toshihiko | - |
| dc.contributor.author | Yu, Jin Quan | - |
| dc.date.accessioned | 2019-09-18T08:33:46Z | - |
| dc.date.available | 2019-09-18T08:33:46Z | - |
| dc.date.issued | 2015 | - |
| dc.identifier.citation | Angewandte Chemie - International Edition, 2015, v. 54, n. 22, p. 6545-6549 | - |
| dc.identifier.issn | 1433-7851 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/276494 | - |
| dc.description.abstract | © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. An intermolecular C(sp3)-H amination using a Pd0/PAr3 catalyst was developed. The reaction begins with oxidative addition of R2N-OBz to a Pd0/PAr3 catalyst and subsequent cleavage of a C(sp3)-H bond by the generated Pd-NR2 intermediate. The catalytic cycle proceeds without the need for external oxidants in a similar manner to the extensively studied palladium(0)-catalyzed C-H arylation reactions. The electron-deficient triarylphosphine ligand is crucial for this C(sp3)-H amination reaction to occur. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Angewandte Chemie - International Edition | - |
| dc.subject | synthetic methods | - |
| dc.subject | amination | - |
| dc.subject | amino acids | - |
| dc.subject | C-H activation | - |
| dc.subject | palladium | - |
| dc.title | Palladium(0)/PAr3-catalyzed intermolecular amination of C(sp3)-H bonds: Synthesis of β-amino acids | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1002/anie.201502075 | - |
| dc.identifier.pmid | 25873526 | - |
| dc.identifier.scopus | eid_2-s2.0-84930194013 | - |
| dc.identifier.volume | 54 | - |
| dc.identifier.issue | 22 | - |
| dc.identifier.spage | 6545 | - |
| dc.identifier.epage | 6549 | - |
| dc.identifier.eissn | 1521-3773 | - |
| dc.identifier.isi | WOS:000355229800025 | - |
| dc.identifier.issnl | 1433-7851 | - |