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Conference Paper: A retrospective study on amiodarone pulmonary toxicity in Chinese patients in Hong Kong

TitleA retrospective study on amiodarone pulmonary toxicity in Chinese patients in Hong Kong
Authors
Issue Date2017
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RES
Citation
22nd Congress of the Asian Pacific Society of Respirology (APSR), Sydney, Australia, 23–26 November 2017. In Respirology, 2017, v. 22 n. Suppl. 3, p. 23, abstract no. AO044 How to Cite?
AbstractBackground and Aim:Amiodarone is one of the most commonlyused anti-arrhythmic agents in atrial and ventricular arrhythmias. Amiodar-one pulmonary toxicity is a potentially fatal adverse effect associated withamiodarone use. Previous studies on the epidemiology and risk factors foramiodarone pulmonary toxicity showed diverse results. The objective ofthis study is to identify clinico-epidemiologic markers associated with amio-darone pulmonary toxicity in a cohort with defined amiodarone exposure.Methods:List of patients taking amiodarone who were managed inQueen Mary Hospital and Grantham Hospital from 2005 to 2015 wasretrieved. Those who fulfilled the inclusion criteria were obtained and ana-lyzed on the risk factors associated with amiodarone pulmonary toxicity.Results:A total of 25 cases with amiodarone pulmonary toxicity wereidentified among 1113 patients taking amiodarone for at least 90 days from2005 to 2015. The incidence of amiodarone pulmonary toxicity was esti-mated to be 2.2% The risk factors for amiodarone pulmonary toxicityincluded increase in age (OR 1.044, 95% CI 1.008 - 1.082, p = 0.016), ven-tricular arrhythmia (OR 2.757, 95% CI 1.262–6.024, p = 0.011), underlyinglung disease (OR 3.885, 95% CI 1.584–9.528, p = 0.003) and cumulativedose of amiodarone (OR 5.457, 95% CI 1.515–19.660 p = 0.009).Conclusion:The incidence of amiodarone pulmonary toxicity in Chi-nese patients in Hong Kong is estimated to be 2.2% in this study. Age,underlying lung disease, ventricular arrhythmia and cumulative dose ofamiodarone are associated with the development of amiodarone pulmo-nary toxicity. It is worth conducting a prospective clinical study in future tovalidate the findings observed in this study. Acknowledgements: I am grateful for the kind assistance and advice regarding statistical analysis from Mr. Dr. Hei Man Herbert Pang.
DescriptionAwarded best oral abstract - Oral Presentations: Clinical Respiratory Medicine 1
Persistent Identifierhttp://hdl.handle.net/10722/276179
ISSN
2020 Impact Factor: 6.424
2020 SCImago Journal Rankings: 1.857

 

DC FieldValueLanguage
dc.contributor.authorKwok, WC-
dc.contributor.authorMa, TF-
dc.contributor.authorPang, HMH-
dc.contributor.authorHo, JCM-
dc.date.accessioned2019-09-10T02:57:35Z-
dc.date.available2019-09-10T02:57:35Z-
dc.date.issued2017-
dc.identifier.citation22nd Congress of the Asian Pacific Society of Respirology (APSR), Sydney, Australia, 23–26 November 2017. In Respirology, 2017, v. 22 n. Suppl. 3, p. 23, abstract no. AO044-
dc.identifier.issn1323-7799-
dc.identifier.urihttp://hdl.handle.net/10722/276179-
dc.descriptionAwarded best oral abstract - Oral Presentations: Clinical Respiratory Medicine 1-
dc.description.abstractBackground and Aim:Amiodarone is one of the most commonlyused anti-arrhythmic agents in atrial and ventricular arrhythmias. Amiodar-one pulmonary toxicity is a potentially fatal adverse effect associated withamiodarone use. Previous studies on the epidemiology and risk factors foramiodarone pulmonary toxicity showed diverse results. The objective ofthis study is to identify clinico-epidemiologic markers associated with amio-darone pulmonary toxicity in a cohort with defined amiodarone exposure.Methods:List of patients taking amiodarone who were managed inQueen Mary Hospital and Grantham Hospital from 2005 to 2015 wasretrieved. Those who fulfilled the inclusion criteria were obtained and ana-lyzed on the risk factors associated with amiodarone pulmonary toxicity.Results:A total of 25 cases with amiodarone pulmonary toxicity wereidentified among 1113 patients taking amiodarone for at least 90 days from2005 to 2015. The incidence of amiodarone pulmonary toxicity was esti-mated to be 2.2% The risk factors for amiodarone pulmonary toxicityincluded increase in age (OR 1.044, 95% CI 1.008 - 1.082, p = 0.016), ven-tricular arrhythmia (OR 2.757, 95% CI 1.262–6.024, p = 0.011), underlyinglung disease (OR 3.885, 95% CI 1.584–9.528, p = 0.003) and cumulativedose of amiodarone (OR 5.457, 95% CI 1.515–19.660 p = 0.009).Conclusion:The incidence of amiodarone pulmonary toxicity in Chi-nese patients in Hong Kong is estimated to be 2.2% in this study. Age,underlying lung disease, ventricular arrhythmia and cumulative dose ofamiodarone are associated with the development of amiodarone pulmo-nary toxicity. It is worth conducting a prospective clinical study in future tovalidate the findings observed in this study. Acknowledgements: I am grateful for the kind assistance and advice regarding statistical analysis from Mr. Dr. Hei Man Herbert Pang.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RES-
dc.relation.ispartofRespirology-
dc.relation.ispartof22nd Congress of the Asian Pacific Society of Respirology (APSR), 2017-
dc.titleA retrospective study on amiodarone pulmonary toxicity in Chinese patients in Hong Kong-
dc.typeConference_Paper-
dc.identifier.emailPang, HMH: herbpang@hku.hk-
dc.identifier.emailHo, JCM: jhocm@hku.hk-
dc.identifier.authorityPang, HMH=rp01857-
dc.identifier.authorityHo, JCM=rp00258-
dc.identifier.doi10.1111/resp.13206_47-
dc.identifier.hkuros304727-
dc.identifier.volume22-
dc.identifier.issueSuppl. 3-
dc.identifier.spage23, abstract no. AO044-
dc.identifier.epage23, abstract no. AO044-
dc.publisher.placeAustralia-
dc.identifier.issnl1323-7799-

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