File Download
  Links for fulltext
     (May Require Subscription)

Article: Effectiveness of partial and full influenza vaccination in children aged <9 years in Hong Kong, 2011-2019

TitleEffectiveness of partial and full influenza vaccination in children aged <9 years in Hong Kong, 2011-2019
Authors
Keywordsinfluenza
child
Hong Kong
influenza vaccines
orthomyxoviridae
Issue Date2019
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/
Citation
Journal of Infectious Diseases, 2019, v. 220 n. 10, p. 1568-1576 How to Cite?
AbstractINTRODUCTION: Two doses of influenza vaccination are recommended for previously unvaccinated children aged <9 years, and receipt of one dose is sometimes termed 'partial vaccination'. We assessed the vaccine effectiveness (VE) against influenza hospitalization of partial and full influenza vaccination among children in Hong Kong. METHODS: Using the test-negative design we enrolled 23,187 children aged <9 years admitted to hospitals with acute respiratory illness between September 2011 through to March 2019. Vaccination and influenza status were recorded. Fully vaccinated children included those vaccinated with two doses, or one dose if they were previously vaccinated. Partially vaccinated children included those who should receive two doses but received only one dose. We estimated VE using conditional logistic regression models matching on epidemiological week. RESULTS: Overall VE estimates among fully and partially vaccinated children were 73% (95% confidence interval, CI: 69% ,77%) and 31% (95% CI: 8%, 48%), respectively. Consistently higher VE was observed in fully vaccinated children against each influenza type/subtype. VE of partial vaccination did not vary by age groups. CONCLUSIONS: Partial vaccination was significantly less effective than full vaccination. Our study supports the current recommendation of two doses of influenza vaccination in previously unvaccinated children <9 years of age.
Persistent Identifierhttp://hdl.handle.net/10722/276150
ISSN
2019 Impact Factor: 5.022
2015 SCImago Journal Rankings: 4.000

 

DC FieldValueLanguage
dc.contributor.authorChua, HY-
dc.contributor.authorChiu, SSS-
dc.contributor.authorChan, LY-
dc.contributor.authorFeng, S-
dc.contributor.authorKwan, YW-
dc.contributor.authorWong, JSC-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorCowling, BJ-
dc.date.accessioned2019-09-10T02:56:58Z-
dc.date.available2019-09-10T02:56:58Z-
dc.date.issued2019-
dc.identifier.citationJournal of Infectious Diseases, 2019, v. 220 n. 10, p. 1568-1576-
dc.identifier.issn0022-1899-
dc.identifier.urihttp://hdl.handle.net/10722/276150-
dc.description.abstractINTRODUCTION: Two doses of influenza vaccination are recommended for previously unvaccinated children aged <9 years, and receipt of one dose is sometimes termed 'partial vaccination'. We assessed the vaccine effectiveness (VE) against influenza hospitalization of partial and full influenza vaccination among children in Hong Kong. METHODS: Using the test-negative design we enrolled 23,187 children aged <9 years admitted to hospitals with acute respiratory illness between September 2011 through to March 2019. Vaccination and influenza status were recorded. Fully vaccinated children included those vaccinated with two doses, or one dose if they were previously vaccinated. Partially vaccinated children included those who should receive two doses but received only one dose. We estimated VE using conditional logistic regression models matching on epidemiological week. RESULTS: Overall VE estimates among fully and partially vaccinated children were 73% (95% confidence interval, CI: 69% ,77%) and 31% (95% CI: 8%, 48%), respectively. Consistently higher VE was observed in fully vaccinated children against each influenza type/subtype. VE of partial vaccination did not vary by age groups. CONCLUSIONS: Partial vaccination was significantly less effective than full vaccination. Our study supports the current recommendation of two doses of influenza vaccination in previously unvaccinated children <9 years of age.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/-
dc.relation.ispartofJournal of Infectious Diseases-
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Infectious Diseases following peer review. The definitive publisher-authenticated version Journal of Infectious Diseases, 2019, v. 220 n. 10, p. 1568-1576 is available online at: https://academic.oup.com/jid/article-abstract/220/10/1568/5530568?redirectedFrom=fulltext-
dc.subjectinfluenza-
dc.subjectchild-
dc.subjectHong Kong-
dc.subjectinfluenza vaccines-
dc.subjectorthomyxoviridae-
dc.titleEffectiveness of partial and full influenza vaccination in children aged <9 years in Hong Kong, 2011-2019-
dc.typeArticle-
dc.identifier.emailChiu, SSS: ssschiu@hku.hk-
dc.identifier.emailChan, LY: laiyin@hkucc.hku.hk-
dc.identifier.emailFeng, S: shuofeng@connect.hku.hk-
dc.identifier.emailKwan, YW: ywmkwan@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.authorityChiu, SSS=rp00421-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityCowling, BJ=rp01326-
dc.description.naturepostprint-
dc.identifier.doi10.1093/infdis/jiz361-
dc.identifier.hkuros304458-
dc.identifier.volume220-
dc.identifier.issue10-
dc.identifier.spage1568-
dc.identifier.epage1576-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats