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Book Chapter: Monkey Models and HIV Vaccine Research

TitleMonkey Models and HIV Vaccine Research
Authors
KeywordsSIV
HIV
SHIV
AIDS
Vaccine
Issue Date2018
PublisherSpringer
Citation
Monkey Models and HIV Vaccine Research. In Zhang, L and Lewin, SR (Eds.), HIV vaccines and cure : the path towards finding an effective cure and vaccine, p. 97-124. Singapore: Springer, 2018 How to Cite?
HIV vaccines and cure : the path towards finding an effective cure and vaccine, p. 97-124 How to Cite?
AbstractSince the discovery of acquired immunodeficiency syndrome (AIDS) in 1981, it has been extremely difficult to develop an effective vaccine or a therapeutic cure despite over 36 years of global efforts. One of the major reasons is due to the lack of an immune-competent animal model that supports live human immunodeficiency virus (HIV) infection and disease progression such that vaccine-induced correlates of protection and efficacy can be determined clearly before human trials. Nevertheless, rhesus macaques infected with simian immunodeficiency virus (SIV) and chimeric simian human immunodeficiency virus (SHIV) have served as invaluable models not only for understanding AIDS pathogenesis but also for studying HIV vaccine and cure. In this chapter, therefore, we summarize major scientific evidence generated in these models since the beginning of the AIDS pandemic. Hopefully, the accumulated knowledge and lessons contributed by thousands of scientists will be useful in promoting the search of an ultimate solution to end HIV/AIDS.
DescriptionAdvances in Experimental Medicine and Biology book series link_to_subscribed_fulltext
Persistent Identifierhttp://hdl.handle.net/10722/275602
ISBN
ISSN
2021 Impact Factor: 3.650
2023 SCImago Journal Rankings: 0.244
ISI Accession Number ID
Series/Report no.Advances in Experimental Medicine and Biology

 

DC FieldValueLanguage
dc.contributor.authorChen, Z-
dc.date.accessioned2019-09-10T02:45:49Z-
dc.date.available2019-09-10T02:45:49Z-
dc.date.issued2018-
dc.identifier.citationMonkey Models and HIV Vaccine Research. In Zhang, L and Lewin, SR (Eds.), HIV vaccines and cure : the path towards finding an effective cure and vaccine, p. 97-124. Singapore: Springer, 2018-
dc.identifier.citationHIV vaccines and cure : the path towards finding an effective cure and vaccine, p. 97-124-
dc.identifier.isbn9789811304835-
dc.identifier.issn0065-2598-
dc.identifier.urihttp://hdl.handle.net/10722/275602-
dc.descriptionAdvances in Experimental Medicine and Biology book series link_to_subscribed_fulltext -
dc.description.abstractSince the discovery of acquired immunodeficiency syndrome (AIDS) in 1981, it has been extremely difficult to develop an effective vaccine or a therapeutic cure despite over 36 years of global efforts. One of the major reasons is due to the lack of an immune-competent animal model that supports live human immunodeficiency virus (HIV) infection and disease progression such that vaccine-induced correlates of protection and efficacy can be determined clearly before human trials. Nevertheless, rhesus macaques infected with simian immunodeficiency virus (SIV) and chimeric simian human immunodeficiency virus (SHIV) have served as invaluable models not only for understanding AIDS pathogenesis but also for studying HIV vaccine and cure. In this chapter, therefore, we summarize major scientific evidence generated in these models since the beginning of the AIDS pandemic. Hopefully, the accumulated knowledge and lessons contributed by thousands of scientists will be useful in promoting the search of an ultimate solution to end HIV/AIDS.-
dc.languageeng-
dc.publisherSpringer-
dc.relation.ispartofHIV vaccines and cure : the path towards finding an effective cure and vaccine-
dc.relation.ispartofHIV疫苗与治疗-
dc.relation.ispartofseriesAdvances in Experimental Medicine and Biology-
dc.subjectSIV-
dc.subjectHIV-
dc.subjectSHIV-
dc.subjectAIDS-
dc.subjectVaccine-
dc.titleMonkey Models and HIV Vaccine Research-
dc.typeBook_Chapter-
dc.identifier.emailChen, Z: zchenai@hku.hk-
dc.identifier.authorityChen, Z=rp00243-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/978-981-13-0484-2-
dc.identifier.hkuros303927-
dc.identifier.volumeMonkey Models and HIV Vaccine Research-
dc.identifier.spage97-
dc.identifier.epage124-
dc.identifier.eissn2214-8019-
dc.identifier.isiWOS:000453886500006-
dc.publisher.placeSingapore-
dc.identifier.issnl0065-2598-

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