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Conference Paper: DWI predicts surgical outcome in advanced ovarian cancer

TitleDWI predicts surgical outcome in advanced ovarian cancer
Authors
Issue Date2019
PublisherSpringerOpen. The Journal's web site is located at http://www.springer.com/medicine/radiology/journal/13244
Citation
European Congress of Radiology 25th Annual Meeting, Vienna, Austria, 27 February - 3 March 2019. In Insights into Imaging , 2019, v. 10 n. Suppl. 1, p. S264, article no. B-0370 How to Cite?
AbstractPurpose: To evaluate the values of DWI-derived tumour burden of peritoneal carcinomatosis (PC) and its biology in determining the surgical outcome in advanced ovarian cancer (AOC). Methods and Materials: Thirty-four AOC patients were prospectively recruited with pre-surgical DWI (b=0, 400, 800 s/mm2 ). Tumours with intermediate apparent diffusion coefficient (ADC) segmented by k-means clustering were used for solid tumour volume (STV) calculation discarding fatty, fibrous or cystic tissues. A functional peritoneal cancer index (fPCI) was generated by adding up all STVs from 13 abdominopelvic regions with additional points if porto hepatis, mesentery or bowel serosa were involved. Mean ADC was measured from 3 selected lesions with the largest STVs. At surgery, the surgical PCI (sPCI), surgical duration and surgical outcome (complete cytoreductive surgery or with residual disease) were recorded. Mann-Whitney U test, Pearson correlation (r) and logistic regressions were performed. Results: Patients who achieved complete cytoreductive surgery had lower fPCI (4.30 vs 10.18) and sPCI (5.70 vs 12.00) but higher ADC (0.97 vs 0.73) than patients with residual disease (p < 0.005). fPCI was significantly correlated with sPCI (r=0.899, p<0.001) and surgical duration (r=0.528, p=0.001). fPCI, sPCI and ADC (r=0.507, 0.529, -0.562) were significantly correlated with residual disease (p<0.005). Both fPCI and ADC were significant in univariate and multivariate analyses (p<0.05; accuracy=82.4%, sensitivity=72.7%, specificity = 87.0%). Conclusion: Pre-surgical fPCI and ADC were significant predictors for complete cytoreductive surgery in AOC.
Persistent Identifierhttp://hdl.handle.net/10722/275246
ISSN
2019 Impact Factor: 3.579
2015 SCImago Journal Rankings: 1.004

 

DC FieldValueLanguage
dc.contributor.authorAn, H-
dc.contributor.authorLee, EYP-
dc.contributor.authorPerucho, JAU-
dc.contributor.authorChiu, WHK-
dc.contributor.authorChu, MYM-
dc.contributor.authorTse, KY-
dc.date.accessioned2019-09-10T02:38:38Z-
dc.date.available2019-09-10T02:38:38Z-
dc.date.issued2019-
dc.identifier.citationEuropean Congress of Radiology 25th Annual Meeting, Vienna, Austria, 27 February - 3 March 2019. In Insights into Imaging , 2019, v. 10 n. Suppl. 1, p. S264, article no. B-0370-
dc.identifier.issn1869-4101-
dc.identifier.urihttp://hdl.handle.net/10722/275246-
dc.description.abstractPurpose: To evaluate the values of DWI-derived tumour burden of peritoneal carcinomatosis (PC) and its biology in determining the surgical outcome in advanced ovarian cancer (AOC). Methods and Materials: Thirty-four AOC patients were prospectively recruited with pre-surgical DWI (b=0, 400, 800 s/mm2 ). Tumours with intermediate apparent diffusion coefficient (ADC) segmented by k-means clustering were used for solid tumour volume (STV) calculation discarding fatty, fibrous or cystic tissues. A functional peritoneal cancer index (fPCI) was generated by adding up all STVs from 13 abdominopelvic regions with additional points if porto hepatis, mesentery or bowel serosa were involved. Mean ADC was measured from 3 selected lesions with the largest STVs. At surgery, the surgical PCI (sPCI), surgical duration and surgical outcome (complete cytoreductive surgery or with residual disease) were recorded. Mann-Whitney U test, Pearson correlation (r) and logistic regressions were performed. Results: Patients who achieved complete cytoreductive surgery had lower fPCI (4.30 vs 10.18) and sPCI (5.70 vs 12.00) but higher ADC (0.97 vs 0.73) than patients with residual disease (p < 0.005). fPCI was significantly correlated with sPCI (r=0.899, p<0.001) and surgical duration (r=0.528, p=0.001). fPCI, sPCI and ADC (r=0.507, 0.529, -0.562) were significantly correlated with residual disease (p<0.005). Both fPCI and ADC were significant in univariate and multivariate analyses (p<0.05; accuracy=82.4%, sensitivity=72.7%, specificity = 87.0%). Conclusion: Pre-surgical fPCI and ADC were significant predictors for complete cytoreductive surgery in AOC.-
dc.languageeng-
dc.publisherSpringerOpen. The Journal's web site is located at http://www.springer.com/medicine/radiology/journal/13244-
dc.relation.ispartofInsights into Imaging-
dc.relation.ispartofEuropean Congress of Radiology 25th Annual Meeting, 2019-
dc.titleDWI predicts surgical outcome in advanced ovarian cancer-
dc.typeConference_Paper-
dc.identifier.emailLee, EYP: eyplee77@hku.hk-
dc.identifier.emailChiu, WHK: kwhchiu@hku.hk-
dc.identifier.emailChu, MYM: chumy@hku.hk-
dc.identifier.emailTse, KY: tseky@hku.hk-
dc.identifier.authorityLee, EYP=rp01456-
dc.identifier.authorityChiu, WHK=rp02074-
dc.identifier.authorityTse, KY=rp02391-
dc.identifier.hkuros303951-
dc.identifier.hkuros312795-
dc.identifier.volume10-
dc.identifier.issueSuppl. 1-
dc.identifier.spageS264-
dc.identifier.epageS264-
dc.publisher.placeGermany-

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