Comparison of Liver Apparent Diffusion Coefficient (ADC) Measurement Using Single-shot and Multi-shot Diffusion-weighted EPI

Abstract

Diffusion-weighted imaging has been shown useful in measuring liver apparent diffusion coefficient (ADC) that can provide valuable information for clinical diagnosis. Single-shot diffusion-weighted echo-planar imaging (ssDW-EPI) is the preferred acquisition technique for ADC measurement on clinical MRI scanner. Recently, a multiplexed sensitivity encoding (MUSE) framework has been developed to reconstruct high-quality multi-shot DW-EPI (msDW-EPI) image in brain. In this study, we aim to evaluate the msDW-EPI technique on liver ADC measurement by quantitatively comparing measured ADC values obtained from either msDW-EPI or ssDW-EPI.