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Conference Paper: A Luminescence Turn-On Assay for Acetylcholinesterase Activity and Inhibitor Screening Based on Supramolecular Self-Assembly of Alkynylplatinum(II) Complexes on Coordination Polymer
| Title | A Luminescence Turn-On Assay for Acetylcholinesterase Activity and Inhibitor Screening Based on Supramolecular Self-Assembly of Alkynylplatinum(II) Complexes on Coordination Polymer |
|---|---|
| Authors | |
| Issue Date | 2019 |
| Publisher | The Chinese University of Hong Kong. |
| Citation | The 26th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, Hong Kong, 4 May 2019, p. INORG-47 How to Cite? |
| Abstract | A new approach toward acetylcholinesterase (AChE) detection has been demonstrated based on the electrostatic interactions between anionic alkynylplatinum(II) complex molecules and cationic coordination polymer, together with the spectroscopic and emission characteristics of alkynylplatinum(II) complexes upon supramolecular selfassembly. This process involves strengthening of distinct noncovalent Pt(II)···Pt(II) and π-π stacking interactions, which is evidenced by UVvis absorption, emission, and resonance light scattering results. Such a method has been applied to AChE inhibitor
screening, which is important as the demand for AChE inhibitor assays arises along with the drug development for Alzheimer’s disease. It affords an emission turn-on response and operates in a continuous and label-free fashion. The low-energy red emission and large Stokes shift of alkynylplatinum(II) complexes are advantageous to biological applications.
Reference: Law A. S.-Y.; Yeung M. C.-L.; Yam V. W.-W. ACS Appl. Mater. Interfaces, 2019, 11,
47994808. |
| Description | Organizer: Department of Chemistry, The Chinese University of Hong Kong |
| Persistent Identifier | http://hdl.handle.net/10722/275223 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Law, ASY | - |
| dc.contributor.author | Yeung, CLM | - |
| dc.contributor.author | Yam, VWW | - |
| dc.date.accessioned | 2019-09-10T02:38:08Z | - |
| dc.date.available | 2019-09-10T02:38:08Z | - |
| dc.date.issued | 2019 | - |
| dc.identifier.citation | The 26th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, Hong Kong, 4 May 2019, p. INORG-47 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/275223 | - |
| dc.description | Organizer: Department of Chemistry, The Chinese University of Hong Kong | - |
| dc.description.abstract | A new approach toward acetylcholinesterase (AChE) detection has been demonstrated based on the electrostatic interactions between anionic alkynylplatinum(II) complex molecules and cationic coordination polymer, together with the spectroscopic and emission characteristics of alkynylplatinum(II) complexes upon supramolecular selfassembly. This process involves strengthening of distinct noncovalent Pt(II)···Pt(II) and π-π stacking interactions, which is evidenced by UVvis absorption, emission, and resonance light scattering results. Such a method has been applied to AChE inhibitor screening, which is important as the demand for AChE inhibitor assays arises along with the drug development for Alzheimer’s disease. It affords an emission turn-on response and operates in a continuous and label-free fashion. The low-energy red emission and large Stokes shift of alkynylplatinum(II) complexes are advantageous to biological applications. Reference: Law A. S.-Y.; Yeung M. C.-L.; Yam V. W.-W. ACS Appl. Mater. Interfaces, 2019, 11, 47994808. | - |
| dc.language | eng | - |
| dc.publisher | The Chinese University of Hong Kong. | - |
| dc.relation.ispartof | The 26th Symposium on Chemistry Postgraduate Research in Hong Kong, 2019 | - |
| dc.title | A Luminescence Turn-On Assay for Acetylcholinesterase Activity and Inhibitor Screening Based on Supramolecular Self-Assembly of Alkynylplatinum(II) Complexes on Coordination Polymer | - |
| dc.type | Conference_Paper | - |
| dc.identifier.email | Yam, VWW: wwyam@hku.hk | - |
| dc.identifier.authority | Yam, VWW=rp00822 | - |
| dc.identifier.hkuros | 304932 | - |
| dc.identifier.spage | INORG-47 | - |
| dc.identifier.epage | INORG-47 | - |
| dc.publisher.place | Hong Kong | - |