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Article: Overexpression of Pin1 and rho signaling partners correlates with metastatic behavior and poor recurrence-free survival of hepatocellular carcinoma patients

TitleOverexpression of Pin1 and rho signaling partners correlates with metastatic behavior and poor recurrence-free survival of hepatocellular carcinoma patients
Authors
KeywordsPin1
RhoA
RhoC
Metastasis
Issue Date2019
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmccancer/
Citation
BMC Cancer, 2019, v. 19, p. article no. 713 How to Cite?
AbstractBackground: Identification of molecular markers for early detection or prediction of metastasis is crucial for both management of HCC patient postoperative treatment and identify new therapeutic targets to inhibit HCC progression and metastasis. In the current study, we investigated the clinical correlation between Pin1, RhoA and RhoC and their association with HCC metastasis. Methods: Using a randomized study design of primary HCC samples from 139 patients, we determined messenger RNA expression of Pin1, RhoA and RhoC and their prognostic value. Results: Our findings demonstrated for the first time the clinical correlation of Pin1 in HCC metastasis. Pin1, RhoA and RhoC transcript levels were significantly higher in HCC specimens when compared with the paired adjacent non-tumorous liver. Pin1 overexpression was closely correlated with that of RhoA (R = 0.562, p < 0.001) and RhoC (R = 0.529, p < 0.001), and their co-overexpressions correlated with metastatic HCC (p = 0.000012) and poor recurrence-free survival of HCC patients (p < 0.00001), which showed better prognostic significance than either Pin1, RhoA or RhoC overexpression alone. Co-overexpressions of Pin1 + RhoA/RhoC were also an independent factor for predicting development of metastasis after curative resection in our multivariate regression model (p < 0.001). Conclusion: Pin1, RhoA and RhoC co-overexpressions are prognostic factor for metastatic HCC and predict poor recurrence-free survival.
Persistent Identifierhttp://hdl.handle.net/10722/275132
ISSN
2018 Impact Factor: 2.933
2015 SCImago Journal Rankings: 1.627
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorNg, L-
dc.contributor.authorKwan, V-
dc.contributor.authorChow, A-
dc.contributor.authorYau, TCC-
dc.contributor.authorPoon, RTP-
dc.contributor.authorPang, R-
dc.contributor.authorLaw, WL-
dc.date.accessioned2019-09-10T02:36:08Z-
dc.date.available2019-09-10T02:36:08Z-
dc.date.issued2019-
dc.identifier.citationBMC Cancer, 2019, v. 19, p. article no. 713-
dc.identifier.issn1471-2407-
dc.identifier.urihttp://hdl.handle.net/10722/275132-
dc.description.abstractBackground: Identification of molecular markers for early detection or prediction of metastasis is crucial for both management of HCC patient postoperative treatment and identify new therapeutic targets to inhibit HCC progression and metastasis. In the current study, we investigated the clinical correlation between Pin1, RhoA and RhoC and their association with HCC metastasis. Methods: Using a randomized study design of primary HCC samples from 139 patients, we determined messenger RNA expression of Pin1, RhoA and RhoC and their prognostic value. Results: Our findings demonstrated for the first time the clinical correlation of Pin1 in HCC metastasis. Pin1, RhoA and RhoC transcript levels were significantly higher in HCC specimens when compared with the paired adjacent non-tumorous liver. Pin1 overexpression was closely correlated with that of RhoA (R = 0.562, p < 0.001) and RhoC (R = 0.529, p < 0.001), and their co-overexpressions correlated with metastatic HCC (p = 0.000012) and poor recurrence-free survival of HCC patients (p < 0.00001), which showed better prognostic significance than either Pin1, RhoA or RhoC overexpression alone. Co-overexpressions of Pin1 + RhoA/RhoC were also an independent factor for predicting development of metastasis after curative resection in our multivariate regression model (p < 0.001). Conclusion: Pin1, RhoA and RhoC co-overexpressions are prognostic factor for metastatic HCC and predict poor recurrence-free survival.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmccancer/-
dc.relation.ispartofBMC Cancer-
dc.rightsBMC Cancer. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectPin1-
dc.subjectRhoA-
dc.subjectRhoC-
dc.subjectMetastasis-
dc.titleOverexpression of Pin1 and rho signaling partners correlates with metastatic behavior and poor recurrence-free survival of hepatocellular carcinoma patients-
dc.typeArticle-
dc.identifier.emailNg, L: luing@hku.hk-
dc.identifier.emailYau, TCC: tyaucc@hku.hk-
dc.identifier.emailPoon, RTP: poontp@hku.hk-
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hk-
dc.identifier.authorityNg, L=rp02207-
dc.identifier.authorityYau, TCC=rp01466-
dc.identifier.authorityPoon, RTP=rp00446-
dc.identifier.authorityPang, R=rp00274-
dc.identifier.authorityLaw, WL=rp00436-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s12885-019-5919-3-
dc.identifier.pmid31324164-
dc.identifier.pmcidPMC6642482-
dc.identifier.scopuseid_2-s2.0-85069433253-
dc.identifier.hkuros304769-
dc.identifier.volume19-
dc.identifier.spagearticle no. 713-
dc.identifier.epagearticle no. 713-
dc.publisher.placeUnited Kingdom-

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