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- Publisher Website: 10.1016/j.semnephrol.2018.05.018
- Scopus: eid_2-s2.0-85052652213
- PMID: 30177020
- WOS: WOS:000443239900007
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Article: Role of Mesangial-Podocytic-Tubular Cross-Talk in IgA Nephropathy
Title | Role of Mesangial-Podocytic-Tubular Cross-Talk in IgA Nephropathy |
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Authors | |
Keywords | IgAN Cross-talk Mesangial cell Podocyte Tubular |
Issue Date | 2018 |
Publisher | WB Saunders Co. The Journal's web site is located at http://www.seminarsinnephrology.org/ |
Citation | Seminars in Nephrology, 2018, v. 38 n. 5, p. 485-495 How to Cite? |
Abstract | IgA nephropathy (IgAN), a common primary glomerulonephritis worldwide, is associated with a substantial risk of progression to end-stage renal failure. The disease runs a highly variable clinical course with frequent involvement of tubulointerstitial damage. A subgroup of IgAN with proximal tubular epithelial cells (PTECs) and tubulointerstitial damage often is associated with rapid progression to end-stage renal failure. Human mesangial cell–derived mediators lead to podocyte and tubulointerstitial injury via mesangial-podocytic-tubular cross-talk. Although mesangial-podocytic communication plays a pathogenic role in podocytic injury, the implication of a podocyte-PTEC cross-talk pathway in the progression of tubulointerstitial injury in IgAN should not be underscored. We review the role of mesangial-podocytic-tubular cross-talk in the progression of IgAN. We discuss how podocytopathy in IgAN promotes subsequent PTEC dysfunction and whether tubulointerstitial injury affects the propagation of podocytic injury in IgAN. A thorough understanding of the cross-talk mechanisms among mesangial cells, podocytes, and PTECs may lead to better design of potential therapeutic options for IgAN. |
Persistent Identifier | http://hdl.handle.net/10722/275088 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.855 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Leung, JCK | - |
dc.contributor.author | Lai, KN | - |
dc.contributor.author | Tang, SCW | - |
dc.date.accessioned | 2019-09-10T02:35:12Z | - |
dc.date.available | 2019-09-10T02:35:12Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Seminars in Nephrology, 2018, v. 38 n. 5, p. 485-495 | - |
dc.identifier.issn | 0270-9295 | - |
dc.identifier.uri | http://hdl.handle.net/10722/275088 | - |
dc.description.abstract | IgA nephropathy (IgAN), a common primary glomerulonephritis worldwide, is associated with a substantial risk of progression to end-stage renal failure. The disease runs a highly variable clinical course with frequent involvement of tubulointerstitial damage. A subgroup of IgAN with proximal tubular epithelial cells (PTECs) and tubulointerstitial damage often is associated with rapid progression to end-stage renal failure. Human mesangial cell–derived mediators lead to podocyte and tubulointerstitial injury via mesangial-podocytic-tubular cross-talk. Although mesangial-podocytic communication plays a pathogenic role in podocytic injury, the implication of a podocyte-PTEC cross-talk pathway in the progression of tubulointerstitial injury in IgAN should not be underscored. We review the role of mesangial-podocytic-tubular cross-talk in the progression of IgAN. We discuss how podocytopathy in IgAN promotes subsequent PTEC dysfunction and whether tubulointerstitial injury affects the propagation of podocytic injury in IgAN. A thorough understanding of the cross-talk mechanisms among mesangial cells, podocytes, and PTECs may lead to better design of potential therapeutic options for IgAN. | - |
dc.language | eng | - |
dc.publisher | WB Saunders Co. The Journal's web site is located at http://www.seminarsinnephrology.org/ | - |
dc.relation.ispartof | Seminars in Nephrology | - |
dc.subject | IgAN | - |
dc.subject | Cross-talk | - |
dc.subject | Mesangial cell | - |
dc.subject | Podocyte | - |
dc.subject | Tubular | - |
dc.title | Role of Mesangial-Podocytic-Tubular Cross-Talk in IgA Nephropathy | - |
dc.type | Article | - |
dc.identifier.email | Leung, JCK: jckleung@hku.hk | - |
dc.identifier.email | Lai, KN: knlai@hku.hk | - |
dc.identifier.email | Tang, SCW: scwtang@hku.hk | - |
dc.identifier.authority | Leung, JCK=rp00448 | - |
dc.identifier.authority | Lai, KN=rp00324 | - |
dc.identifier.authority | Tang, SCW=rp00480 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.semnephrol.2018.05.018 | - |
dc.identifier.pmid | 30177020 | - |
dc.identifier.scopus | eid_2-s2.0-85052652213 | - |
dc.identifier.hkuros | 303440 | - |
dc.identifier.volume | 38 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 485 | - |
dc.identifier.epage | 495 | - |
dc.identifier.isi | WOS:000443239900007 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0270-9295 | - |