File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1021/acsbiomaterials.8b01228
- Scopus: eid_2-s2.0-85061227896
- WOS: WOS:000480826400004
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Modeling and Simulations of the Dynamic Behaviors of Actin-Based Cytoskeletal Networks
Title | Modeling and Simulations of the Dynamic Behaviors of Actin-Based Cytoskeletal Networks |
---|---|
Authors | |
Keywords | cytoskeletal network mechanical behavior theory modeling finite element method molecular dynamics simulation |
Issue Date | 2019 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/toc/abseba/current |
Citation | ACS Biomaterials Science & Engineering, 2019, v. 5 n. 8, p. 3720-3734 How to Cite? |
Abstract | The cytoskeleton, a dynamic network of biopolymers with their associated cross-linking and motor proteins, is responsible for stabilizing cell shape and driving cell movement. This paper aims to provide an overview of the theoretical and computational approaches that have been developed to understand the dynamic behaviors and underlying mechanisms of actin-based cytoskeletal networks, connecting their microscopic structure to macroscopic performance across various scales, with implications for the observed nonlinear stress–strain relation, viscoelastic properties, stiffening induced by active motors as well as their biological functions in important processes such as cell adhesion, motility, and mechanosensing. In the future, more sophisticated constitutive theories, continuum level, and molecular dynamics-based simulations of biopolymer networks are expected to provide critical insights for understanding the material–structure–function relation in the cytoskeleton of cells and guiding the development of active biomimetic materials. |
Persistent Identifier | http://hdl.handle.net/10722/275062 |
ISSN | 2023 Impact Factor: 5.4 2023 SCImago Journal Rankings: 1.086 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gong, B | - |
dc.contributor.author | WEI, X | - |
dc.contributor.author | Qian, J | - |
dc.contributor.author | Lin, Y | - |
dc.date.accessioned | 2019-09-10T02:34:40Z | - |
dc.date.available | 2019-09-10T02:34:40Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | ACS Biomaterials Science & Engineering, 2019, v. 5 n. 8, p. 3720-3734 | - |
dc.identifier.issn | 2373-9878 | - |
dc.identifier.uri | http://hdl.handle.net/10722/275062 | - |
dc.description.abstract | The cytoskeleton, a dynamic network of biopolymers with their associated cross-linking and motor proteins, is responsible for stabilizing cell shape and driving cell movement. This paper aims to provide an overview of the theoretical and computational approaches that have been developed to understand the dynamic behaviors and underlying mechanisms of actin-based cytoskeletal networks, connecting their microscopic structure to macroscopic performance across various scales, with implications for the observed nonlinear stress–strain relation, viscoelastic properties, stiffening induced by active motors as well as their biological functions in important processes such as cell adhesion, motility, and mechanosensing. In the future, more sophisticated constitutive theories, continuum level, and molecular dynamics-based simulations of biopolymer networks are expected to provide critical insights for understanding the material–structure–function relation in the cytoskeleton of cells and guiding the development of active biomimetic materials. | - |
dc.language | eng | - |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/toc/abseba/current | - |
dc.relation.ispartof | ACS Biomaterials Science & Engineering | - |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html]. | - |
dc.subject | cytoskeletal network | - |
dc.subject | mechanical behavior | - |
dc.subject | theory modeling | - |
dc.subject | finite element method | - |
dc.subject | molecular dynamics simulation | - |
dc.title | Modeling and Simulations of the Dynamic Behaviors of Actin-Based Cytoskeletal Networks | - |
dc.type | Article | - |
dc.identifier.email | Lin, Y: ylin@hkucc.hku.hk | - |
dc.identifier.authority | Lin, Y=rp00080 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/acsbiomaterials.8b01228 | - |
dc.identifier.scopus | eid_2-s2.0-85061227896 | - |
dc.identifier.hkuros | 304186 | - |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 3720 | - |
dc.identifier.epage | 3734 | - |
dc.identifier.isi | WOS:000480826400004 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 2373-9878 | - |