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Article: Susceptibility-weighted imaging provides complementary value to diffusion-weighted imaging in the differentiation between pyogenic brain abscesses, necrotic glioblastomas, and necrotic metastatic brain tumors

TitleSusceptibility-weighted imaging provides complementary value to diffusion-weighted imaging in the differentiation between pyogenic brain abscesses, necrotic glioblastomas, and necrotic metastatic brain tumors
Authors
KeywordsApparent diffusion coefficient
Susceptibility weighted imaging
Intralesional susceptibility signal
Brain abscess
Glioblastoma
Metastasis
Issue Date2019
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejrad
Citation
European Journal of Radiology, 2019, v. 117, p. 56-61 How to Cite?
AbstractPurpose: The purpose of this retrospective study was to investigate the differentiation of abscess and necrotic tumors, using susceptibility-weighted imaging (SWI) and apparent diffusion coefficients (ADC) either separated or combined. Methods: Imaging was performed on 26 patients with pyogenic brain abscesses, 31 patients with rim-enhancing glioblastomas, and 21 patients with rim-enhancing metastases. The degree of intralesional susceptibility signal (ILSS) was independently assessed by three observers. Average ADC in the lesion core was calculated. After receiver operating characteristic (ROC) analysis, the area under the ROC curve was compared using three different analytical models (ILSS, ADC, and ILSS-ADC combined) to differentiate abscess from the two rim-enhancing necrotic tumors. Results: The ILSS-ADC combined model had greater area under the ROC curves than ILSS or ADC used alone. In this study, the ILSS-ADC combined model showed 100% diagnostic accuracy differentiating abscesses from glioblastoma. The ADC model and the ILSS-ADC combined model performed equally well in distinguishing abscesses from metastases. Conclusion: It is concluded that SWI and ADC are complementary, and the combination of SWI and ADC may improve results compared with the use of only one model. Validation by an independent cohort is the next necessary step to broaden its applicability in routine clinical settings.
Persistent Identifierhttp://hdl.handle.net/10722/274938
ISSN
2019 Impact Factor: 2.687
2015 SCImago Journal Rankings: 1.166
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, PH-
dc.contributor.authorChung, HW-
dc.contributor.authorChang, HC-
dc.contributor.authorFu, JH-
dc.contributor.authorWang, PC-
dc.contributor.authorHsu, SH-
dc.contributor.authorHsu, SS-
dc.contributor.authorLin, HS-
dc.contributor.authorChuang, TC-
dc.date.accessioned2019-09-10T02:31:59Z-
dc.date.available2019-09-10T02:31:59Z-
dc.date.issued2019-
dc.identifier.citationEuropean Journal of Radiology, 2019, v. 117, p. 56-61-
dc.identifier.issn0720-048X-
dc.identifier.urihttp://hdl.handle.net/10722/274938-
dc.description.abstractPurpose: The purpose of this retrospective study was to investigate the differentiation of abscess and necrotic tumors, using susceptibility-weighted imaging (SWI) and apparent diffusion coefficients (ADC) either separated or combined. Methods: Imaging was performed on 26 patients with pyogenic brain abscesses, 31 patients with rim-enhancing glioblastomas, and 21 patients with rim-enhancing metastases. The degree of intralesional susceptibility signal (ILSS) was independently assessed by three observers. Average ADC in the lesion core was calculated. After receiver operating characteristic (ROC) analysis, the area under the ROC curve was compared using three different analytical models (ILSS, ADC, and ILSS-ADC combined) to differentiate abscess from the two rim-enhancing necrotic tumors. Results: The ILSS-ADC combined model had greater area under the ROC curves than ILSS or ADC used alone. In this study, the ILSS-ADC combined model showed 100% diagnostic accuracy differentiating abscesses from glioblastoma. The ADC model and the ILSS-ADC combined model performed equally well in distinguishing abscesses from metastases. Conclusion: It is concluded that SWI and ADC are complementary, and the combination of SWI and ADC may improve results compared with the use of only one model. Validation by an independent cohort is the next necessary step to broaden its applicability in routine clinical settings.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejrad-
dc.relation.ispartofEuropean Journal of Radiology-
dc.subjectApparent diffusion coefficient-
dc.subjectSusceptibility weighted imaging-
dc.subjectIntralesional susceptibility signal-
dc.subjectBrain abscess-
dc.subjectGlioblastoma-
dc.subjectMetastasis-
dc.titleSusceptibility-weighted imaging provides complementary value to diffusion-weighted imaging in the differentiation between pyogenic brain abscesses, necrotic glioblastomas, and necrotic metastatic brain tumors-
dc.typeArticle-
dc.identifier.emailChang, HC: hcchang@hku.hk-
dc.identifier.authorityChang, HC=rp02024-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejrad.2019.05.021-
dc.identifier.pmid31307653-
dc.identifier.scopuseid_2-s2.0-85066484438-
dc.identifier.hkuros303929-
dc.identifier.volume117-
dc.identifier.spage56-
dc.identifier.epage61-
dc.identifier.isiWOS:000475337200008-
dc.publisher.placeIreland-

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