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- Publisher Website: 10.1016/j.jebdp.2018.06.008
- Scopus: eid_2-s2.0-85056288111
- PMID: 30926100
- WOS: WOS:000462355700004
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Article: A meta-epidemiological review of meta-analysis on anti-caries effect of arginine-containing formulations
| Title | A meta-epidemiological review of meta-analysis on anti-caries effect of arginine-containing formulations |
|---|---|
| Authors | |
| Keywords | Arginine Caries Meta-analysis Prevention |
| Issue Date | 2019 |
| Publisher | Mosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jebdp |
| Citation | Journal of Evidence-Based Dental Practice, 2019, v. 19 n. 1, p. 28-33 How to Cite? |
| Abstract | BACKGROUND:
Several significant issues on clinical trials reporting the effect of arginine-containing dental products have been addressed in systematic reviews and meta-analyses identifying the need for high-quality randomized clinical trials. A further methodological analysis of the given systematic reviews with meta-analysis on arginine products might provide information for future high-quality randomized clinical trials and current clinical practice.
OBJECTIVE(S):
The objective was to perform a meta-epidemiological assessment of meta-analyses reporting the anticaries effect of arginine-containing formulations.
METHODS:
The data on risk-of-bias assessment, effect size measure, dispersion of estimated precision, and follow-up period were summarized for the meta-epidemiological review analysis.
RESULTS:
Studies with larger magnitude of effect sizes might present with unclear random sequence generation and unclear allocation concealment representing the selection bias. There was a significant strong negative correlation between the follow-up time and dispersion of precision estimates (rs = -0.79, P = .034).
CONCLUSION:
Results show that clinical trials on arginine dental products have methodological shortcomings. Both the selection bias and follow-up period influence the effect size magnitude and subsequent precision dispersion during evidence synthesis in clinical trials on arginine-containing dental products.
Copyright © 2018 Elsevier Inc. All rights reserved. |
| Description | Link to Free access |
| Persistent Identifier | http://hdl.handle.net/10722/274809 |
| ISSN | 2023 Impact Factor: 4.1 2023 SCImago Journal Rankings: 1.023 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Bijle, MNA | - |
| dc.contributor.author | Ekamabram, M | - |
| dc.contributor.author | Lo, ECM | - |
| dc.contributor.author | Yiu, CKY | - |
| dc.date.accessioned | 2019-09-10T02:29:14Z | - |
| dc.date.available | 2019-09-10T02:29:14Z | - |
| dc.date.issued | 2019 | - |
| dc.identifier.citation | Journal of Evidence-Based Dental Practice, 2019, v. 19 n. 1, p. 28-33 | - |
| dc.identifier.issn | 1532-3382 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/274809 | - |
| dc.description | Link to Free access | - |
| dc.description.abstract | BACKGROUND: Several significant issues on clinical trials reporting the effect of arginine-containing dental products have been addressed in systematic reviews and meta-analyses identifying the need for high-quality randomized clinical trials. A further methodological analysis of the given systematic reviews with meta-analysis on arginine products might provide information for future high-quality randomized clinical trials and current clinical practice. OBJECTIVE(S): The objective was to perform a meta-epidemiological assessment of meta-analyses reporting the anticaries effect of arginine-containing formulations. METHODS: The data on risk-of-bias assessment, effect size measure, dispersion of estimated precision, and follow-up period were summarized for the meta-epidemiological review analysis. RESULTS: Studies with larger magnitude of effect sizes might present with unclear random sequence generation and unclear allocation concealment representing the selection bias. There was a significant strong negative correlation between the follow-up time and dispersion of precision estimates (rs = -0.79, P = .034). CONCLUSION: Results show that clinical trials on arginine dental products have methodological shortcomings. Both the selection bias and follow-up period influence the effect size magnitude and subsequent precision dispersion during evidence synthesis in clinical trials on arginine-containing dental products. Copyright © 2018 Elsevier Inc. All rights reserved. | - |
| dc.language | eng | - |
| dc.publisher | Mosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jebdp | - |
| dc.relation.ispartof | Journal of Evidence-Based Dental Practice | - |
| dc.subject | Arginine | - |
| dc.subject | Caries | - |
| dc.subject | Meta-analysis | - |
| dc.subject | Prevention | - |
| dc.title | A meta-epidemiological review of meta-analysis on anti-caries effect of arginine-containing formulations | - |
| dc.type | Article | - |
| dc.identifier.email | Lo, ECM: edward-lo@hku.hk | - |
| dc.identifier.email | Yiu, CKY: ckyyiu@hkucc.hku.hk | - |
| dc.identifier.authority | Lo, ECM=rp00015 | - |
| dc.identifier.authority | Yiu, CKY=rp00018 | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1016/j.jebdp.2018.06.008 | - |
| dc.identifier.pmid | 30926100 | - |
| dc.identifier.scopus | eid_2-s2.0-85056288111 | - |
| dc.identifier.hkuros | 303878 | - |
| dc.identifier.volume | 19 | - |
| dc.identifier.issue | 1 | - |
| dc.identifier.spage | 28 | - |
| dc.identifier.epage | 33 | - |
| dc.identifier.isi | WOS:000462355700004 | - |
| dc.publisher.place | United States | - |
| dc.identifier.issnl | 1532-3382 | - |