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Conference Paper: A Systematic Study on the Anti-Tumor Effect of Combinatorial miRNA Expression in Hepatocellular Carcinoma
Title | A Systematic Study on the Anti-Tumor Effect of Combinatorial miRNA Expression in Hepatocellular Carcinoma |
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Authors | |
Issue Date | 2019 |
Publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ |
Citation | Proceedings of the American Association for Cancer Research (AACR) Annual Meeting 2019, Atlanta, USA, 29 March - 3 April 2019. In Cancer Research, 2019, v. 79 n. 13, Suppl., Abstract 2589 How to Cite? |
Abstract | Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer mortality worldwide. Treatment options for HCC patients are limited, especially for those with advanced HCC. Deregulation of microRNA (miRNA) expression is frequently observed in HCC, and many cellular targets of miRNAs are genetic regulators of tumorigenesis. In addition, miRNAs interact with each other to coordinate targeted gene expressions. The potential of devising combinatorial miRNA-based therapies for HCC, however, remains largely unexplored. Here, we performed high-throughput CombiGEM screens to characterize the anti-tumorigenic effect of combinatorial miRNA expression. We assembled a library of 1,849 pairwise combinations for 43 human miRNAs that are downregulated in HCC patients/cell lines, and identified four miRNA combinations that exert anti-proliferative effect in HCC cells both in vitro and in vivo. Further experiments are underway to validate and characterize the anti-tumor effect of these newly identified miRNA combinations in HCC. |
Description | Session PO.MCB10.03 - miRNA-based Diagnostics and Therapeutics |
Persistent Identifier | http://hdl.handle.net/10722/274600 |
ISSN | 2023 Impact Factor: 12.5 2023 SCImago Journal Rankings: 3.468 |
DC Field | Value | Language |
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dc.contributor.author | Xu, F | - |
dc.contributor.author | Tong, M | - |
dc.contributor.author | Ma, SKY | - |
dc.contributor.author | Wong, SL | - |
dc.date.accessioned | 2019-08-18T15:05:03Z | - |
dc.date.available | 2019-08-18T15:05:03Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Proceedings of the American Association for Cancer Research (AACR) Annual Meeting 2019, Atlanta, USA, 29 March - 3 April 2019. In Cancer Research, 2019, v. 79 n. 13, Suppl., Abstract 2589 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | http://hdl.handle.net/10722/274600 | - |
dc.description | Session PO.MCB10.03 - miRNA-based Diagnostics and Therapeutics | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer mortality worldwide. Treatment options for HCC patients are limited, especially for those with advanced HCC. Deregulation of microRNA (miRNA) expression is frequently observed in HCC, and many cellular targets of miRNAs are genetic regulators of tumorigenesis. In addition, miRNAs interact with each other to coordinate targeted gene expressions. The potential of devising combinatorial miRNA-based therapies for HCC, however, remains largely unexplored. Here, we performed high-throughput CombiGEM screens to characterize the anti-tumorigenic effect of combinatorial miRNA expression. We assembled a library of 1,849 pairwise combinations for 43 human miRNAs that are downregulated in HCC patients/cell lines, and identified four miRNA combinations that exert anti-proliferative effect in HCC cells both in vitro and in vivo. Further experiments are underway to validate and characterize the anti-tumor effect of these newly identified miRNA combinations in HCC. | - |
dc.language | eng | - |
dc.publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ | - |
dc.relation.ispartof | Cancer Research | - |
dc.relation.ispartof | Proceedings of the American Association for Cancer Research (AACR) Annual Meeting 2019 | - |
dc.title | A Systematic Study on the Anti-Tumor Effect of Combinatorial miRNA Expression in Hepatocellular Carcinoma | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Tong, M: caroltm@hku.hk | - |
dc.identifier.email | Ma, SKY: stefma@hku.hk | - |
dc.identifier.email | Wong, SL: aslw@hku.hk | - |
dc.identifier.authority | Tong, M=rp02568 | - |
dc.identifier.authority | Ma, SKY=rp00506 | - |
dc.identifier.authority | Wong, SL=rp02139 | - |
dc.description.nature | abstract | - |
dc.identifier.doi | 10.1158/1538-7445.AM2019-2589 | - |
dc.identifier.hkuros | 301307 | - |
dc.identifier.volume | 79 | - |
dc.identifier.issue | 13, Suppl. | - |
dc.identifier.spage | Abstract 2589 | - |
dc.identifier.epage | Abstract 2589 | - |
dc.publisher.place | United States | - |