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Article: Cumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification

TitleCumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification
Authors
Keywordscoronary artery disease
rheumatoid
arthritisosteogenesis
inflammation
endothelial progenitor cells
Issue Date2019
PublisherWiley Open Access: Creative Commons Attribution Non-Commercial. The Journal's web site is located at http://jaha.ahajournals.org/
Citation
Journal of the American Heart Association, 2019, v. 8 n. 11, article no. e011540 How to Cite?
AbstractBackground: Rheumatic diseases are related to both abnormal bone turnover and atherogenesis, but a mechanistic link was missing. Methods and Results: We investigated the effect of cumulative rheumatic inflammation (CRI) on risk of coronary calcification in a retrospective cohort of 145 rheumatoid arthritis patients. A time‐adjusted aggregate CRI score was derived by conglomerating all quarterly biomarker encounters of serum C‐reactive protein over 60 months immediately preceding computed tomography coronary angiography. Flow cytometry was performed to measure the osteocalcin‐positive (OCN+) CD34+KDR+ and OCN+CD34+ circulating endothelial progenitor cells (EPCs). Conventional early circulating EPCs CD34+CD133+KDR+ was determined. Coronary calcification was defined as any Agatston score >0. 50% of patients (n=72/145) had coronary calcification. CRI score was associated with presence of coronary calcification (P=0.004) (multivariable‐adjusted: highest versus lowest quartile: odds ratio=5.6 [95% CI 1.1–28.9], P=0.041). Receiver operating characteristics curve revealed divergent behavior of OCN‐expressing circulating EPCs (OCN+CD34+EPCs: area under the curve=0.60, P=0.034; OCN+CD34+KDR+EPCs: area under the curve=0.59, P=0.053, positive predictors) versus conventional early EPCs (CD34+CD133+KDR+: area under the curve=0.60, P=0.034, negative predictor) for coronary calcification, which persisted after multivariable adjustments (OCN+CD34+KDR+ [>75th percentile]: odds ratio=7.2 [95% CI 1.8–27.9], P=0.005; OCN+CD34+EPCs [>75th percentile]: odds ratio=6.0 [95% CI 1.5–23.3], P=0.010; CD34+CD133+KDR+ [>75th percentile: odds ratio=0.3 [95% CI 0.1–1.0], P=0.053). Intriguingly, the CRI score was associated with increased OCN+CD34+EPCs (highest versus lowest quartile: B=+25.6 [95% CI 0.8–50.5] [×103/mL peripheral blood], P=0.043), but reduced CD34+CD133+KDR+EPCs (highest versus lowest quartile: B=−16.2 [95% CI −31.5 to −0.9], P=0.038). Conclusions: Preceding 60 months of CRI is associated with increased risk of coronary calcification and altered OCN expression in circulating EPCs.
Persistent Identifierhttp://hdl.handle.net/10722/274543
ISSN
2023 Impact Factor: 5.0
2023 SCImago Journal Rankings: 2.126
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, YH-
dc.contributor.authorNgai, MC-
dc.contributor.authorChen, Y-
dc.contributor.authorWu, MZ-
dc.contributor.authorYU, YJ-
dc.contributor.authorZHEN, Z-
dc.contributor.authorLai, K-
dc.contributor.authorCheung, T-
dc.contributor.authorHo, LM-
dc.contributor.authorChung, HY-
dc.contributor.authorLau, WCS-
dc.contributor.authorTse, HF-
dc.contributor.authorYiu, KH-
dc.date.accessioned2019-08-18T15:03:49Z-
dc.date.available2019-08-18T15:03:49Z-
dc.date.issued2019-
dc.identifier.citationJournal of the American Heart Association, 2019, v. 8 n. 11, article no. e011540-
dc.identifier.issn2047-9980-
dc.identifier.urihttp://hdl.handle.net/10722/274543-
dc.description.abstractBackground: Rheumatic diseases are related to both abnormal bone turnover and atherogenesis, but a mechanistic link was missing. Methods and Results: We investigated the effect of cumulative rheumatic inflammation (CRI) on risk of coronary calcification in a retrospective cohort of 145 rheumatoid arthritis patients. A time‐adjusted aggregate CRI score was derived by conglomerating all quarterly biomarker encounters of serum C‐reactive protein over 60 months immediately preceding computed tomography coronary angiography. Flow cytometry was performed to measure the osteocalcin‐positive (OCN+) CD34+KDR+ and OCN+CD34+ circulating endothelial progenitor cells (EPCs). Conventional early circulating EPCs CD34+CD133+KDR+ was determined. Coronary calcification was defined as any Agatston score >0. 50% of patients (n=72/145) had coronary calcification. CRI score was associated with presence of coronary calcification (P=0.004) (multivariable‐adjusted: highest versus lowest quartile: odds ratio=5.6 [95% CI 1.1–28.9], P=0.041). Receiver operating characteristics curve revealed divergent behavior of OCN‐expressing circulating EPCs (OCN+CD34+EPCs: area under the curve=0.60, P=0.034; OCN+CD34+KDR+EPCs: area under the curve=0.59, P=0.053, positive predictors) versus conventional early EPCs (CD34+CD133+KDR+: area under the curve=0.60, P=0.034, negative predictor) for coronary calcification, which persisted after multivariable adjustments (OCN+CD34+KDR+ [>75th percentile]: odds ratio=7.2 [95% CI 1.8–27.9], P=0.005; OCN+CD34+EPCs [>75th percentile]: odds ratio=6.0 [95% CI 1.5–23.3], P=0.010; CD34+CD133+KDR+ [>75th percentile: odds ratio=0.3 [95% CI 0.1–1.0], P=0.053). Intriguingly, the CRI score was associated with increased OCN+CD34+EPCs (highest versus lowest quartile: B=+25.6 [95% CI 0.8–50.5] [×103/mL peripheral blood], P=0.043), but reduced CD34+CD133+KDR+EPCs (highest versus lowest quartile: B=−16.2 [95% CI −31.5 to −0.9], P=0.038). Conclusions: Preceding 60 months of CRI is associated with increased risk of coronary calcification and altered OCN expression in circulating EPCs.-
dc.languageeng-
dc.publisherWiley Open Access: Creative Commons Attribution Non-Commercial. The Journal's web site is located at http://jaha.ahajournals.org/-
dc.relation.ispartofJournal of the American Heart Association-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcoronary artery disease-
dc.subjectrheumatoid-
dc.subjectarthritisosteogenesis-
dc.subjectinflammation-
dc.subjectendothelial progenitor cells-
dc.titleCumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification-
dc.typeArticle-
dc.identifier.emailChen, Y: cheny818@hku.hk-
dc.identifier.emailWu, MZ: wmz513@hku.hk-
dc.identifier.emailLai, K: kwhlai@hku.hk-
dc.identifier.emailCheung, T: tcheungt@HKUCC-COM.hku.hk-
dc.identifier.emailHo, LM: lmho@hku.hk-
dc.identifier.emailChung, HY: jameschy@hku.hk-
dc.identifier.emailLau, WCS: cslau@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.authorityCheung, T=rp01682-
dc.identifier.authorityHo, LM=rp00360-
dc.identifier.authorityChung, HY=rp02330-
dc.identifier.authorityLau, WCS=rp01348-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityYiu, KH=rp01490-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1161/JAHA.118.011540-
dc.identifier.pmid31130038-
dc.identifier.pmcidPMC6585350-
dc.identifier.scopuseid_2-s2.0-85066942239-
dc.identifier.hkuros302267-
dc.identifier.volume8-
dc.identifier.issue11-
dc.identifier.spagearticle no. e011540-
dc.identifier.epagearticle no. e011540-
dc.identifier.isiWOS:000484576200014-
dc.publisher.placeUnited States-
dc.identifier.issnl2047-9980-

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