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Article: Relationship of pericardial fat with lipoprotein distribution: The Multi-Ethnic study of atherosclerosis

TitleRelationship of pericardial fat with lipoprotein distribution: The Multi-Ethnic study of atherosclerosis
Authors
KeywordsCardiovascular disease
Lipids
Lipoproteins
Pericardial fat
Subclinical atherosclerosis
Issue Date2015
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
Citation
Atherosclerosis, 2015, v. 241 n. 2, p. 664-670 How to Cite?
AbstractObjective: Pericardial fat and lipoprotein abnormalities contribute to increased risk of cardiovascular disease (CVD). We investigated the relationship between pericardial fat volume and lipoprotein distribution, and whether the association of pericardial fat volume with subclinical atherosclerosis and incident CVD events differs according to lipoprotein distribution. Methods: We analyzed data from 5407 participants from the Multi-Ethnic Study of Atherosclerosis who had measurements of pericardial fat volume, lipoprotein distribution, carotid intima-media thickness (IMT), and coronary artery calcium (CAC). All participants were free of clinically apparent CVD at baseline. Incident CVD was defined as any adjudicated CVD event. Results: After adjusting for demographic factors, traditional risk factors, and biomarkers of inflammation and hemostasis, a larger pericardial fat volume was associated with higher large VLDL particle (VLDL-P) concentration and small HDL particle (HDL-P) concentration, and smaller HDL-P size (regression coefficients = 0.585 nmol/L, 0.366 μmol/L, and −0.025 nm per SD increase in pericardial fat volume respectively, all P < 0.05). The association of pericardial fat volume with large VLDL-P concentration and HDL-P size, but not small HDL-P concentration, remained significant after further adjusting for each other as well as LDL cholesterol, HDL cholesterol, and triglycerides. The relationship of pericardial fat volume with incident CVD events, carotid IMT, and prevalence and severity of CAC did not differ by quartiles of large VLDL-P concentration, small HDL-P concentration, or HDL-P size (P for interaction>0.05). Conclusion: Pericardial fat is associated with atherogenic lipoprotein abnormalities. However, its relationship with subclinical atherosclerosis and incident CVD events does not differ according to lipoprotein distribution.
Persistent Identifierhttp://hdl.handle.net/10722/274417
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.461
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorOng, KL-
dc.contributor.authorDing, J-
dc.contributor.authorMcClelland, RL-
dc.contributor.authorCheung, BMY-
dc.contributor.authorCriqui, MH-
dc.contributor.authorBarter, PJ-
dc.contributor.authorRye, KA-
dc.contributor.authorAllison, MA-
dc.date.accessioned2019-08-18T15:01:18Z-
dc.date.available2019-08-18T15:01:18Z-
dc.date.issued2015-
dc.identifier.citationAtherosclerosis, 2015, v. 241 n. 2, p. 664-670-
dc.identifier.issn0021-9150-
dc.identifier.urihttp://hdl.handle.net/10722/274417-
dc.description.abstractObjective: Pericardial fat and lipoprotein abnormalities contribute to increased risk of cardiovascular disease (CVD). We investigated the relationship between pericardial fat volume and lipoprotein distribution, and whether the association of pericardial fat volume with subclinical atherosclerosis and incident CVD events differs according to lipoprotein distribution. Methods: We analyzed data from 5407 participants from the Multi-Ethnic Study of Atherosclerosis who had measurements of pericardial fat volume, lipoprotein distribution, carotid intima-media thickness (IMT), and coronary artery calcium (CAC). All participants were free of clinically apparent CVD at baseline. Incident CVD was defined as any adjudicated CVD event. Results: After adjusting for demographic factors, traditional risk factors, and biomarkers of inflammation and hemostasis, a larger pericardial fat volume was associated with higher large VLDL particle (VLDL-P) concentration and small HDL particle (HDL-P) concentration, and smaller HDL-P size (regression coefficients = 0.585 nmol/L, 0.366 μmol/L, and −0.025 nm per SD increase in pericardial fat volume respectively, all P < 0.05). The association of pericardial fat volume with large VLDL-P concentration and HDL-P size, but not small HDL-P concentration, remained significant after further adjusting for each other as well as LDL cholesterol, HDL cholesterol, and triglycerides. The relationship of pericardial fat volume with incident CVD events, carotid IMT, and prevalence and severity of CAC did not differ by quartiles of large VLDL-P concentration, small HDL-P concentration, or HDL-P size (P for interaction>0.05). Conclusion: Pericardial fat is associated with atherogenic lipoprotein abnormalities. However, its relationship with subclinical atherosclerosis and incident CVD events does not differ according to lipoprotein distribution.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis-
dc.relation.ispartofAtherosclerosis-
dc.subjectCardiovascular disease-
dc.subjectLipids-
dc.subjectLipoproteins-
dc.subjectPericardial fat-
dc.subjectSubclinical atherosclerosis-
dc.titleRelationship of pericardial fat with lipoprotein distribution: The Multi-Ethnic study of atherosclerosis-
dc.typeArticle-
dc.identifier.emailCheung, BMY: mycheung@hkucc.hku.hk-
dc.identifier.authorityCheung, BMY=rp01321-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.atherosclerosis.2015.06.027-
dc.identifier.pmid26117404-
dc.identifier.pmcidPMC4510019-
dc.identifier.scopuseid_2-s2.0-84932644477-
dc.identifier.hkuros302232-
dc.identifier.volume241-
dc.identifier.issue2-
dc.identifier.spage664-
dc.identifier.epage670-
dc.identifier.isiWOS:000360100700048-
dc.publisher.placeIreland-
dc.identifier.issnl0021-9150-

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