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Article: Indirect effects of body mass index growth on glucose dysregulation via inflammation: Causal moderated mediation analysis
Title | Indirect effects of body mass index growth on glucose dysregulation via inflammation: Causal moderated mediation analysis |
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Authors | |
Keywords | C-reactive protein Childhood obesity Inflammation Moderated mediation Prediabetes |
Issue Date | 2019 |
Publisher | Karger Publishers Open Access. The Journal's web site is located at https://www.karger.com/Journal/Home/233731 |
Citation | Obesity Facts, 2019, v. 12 n. 3, p. 316-327 How to Cite? |
Abstract | Objective: No existing studies have examined the mediating role of chronic inflammation between obesity and dysregulated glucose homeostasis in adolescent samples. This study evaluated whether C-reactive protein (CRP), an inflammation biomarker, mediated the effects of growth (annual increase) in body mass index (BMI) on glycated hemoglobin (HbA1c). Methods: BMI and biomarker data were used from wave I to wave IV of the National Longitudinal Study of Adolescent to Adult Health (Add Health study; 4,545 adolescents; mean age = 14.9 years; 55.7% female) with valid CRP data. A causal moderated mediation analysis evaluated the direct and indirect effects of BMI slope on HbA1c via CRP across gender, with demographic and clinical characteristics as model covariates. Results: The participants displayed a linear BMI growth of 0.53–0.58 kg/m2/year throughout adolescence, with substantial interindividual variation. The BMI slope showed positive direct and indirect effects on HbA1c via CRP across gender, and there was a significant exposure-mediator interaction effect. A standardized increase in the BMI slope raised the probability of an abnormal HbA1c value by 6.0–8.5% in participants with various profiles. The total natural indirect effect accounted for 13.3–15.9% of the total effect in males and 21.2–22.7% in females. Conclusions: The findings provide support for the inflammation mechanism in the effects of adiposity on glucose homeostasis. In adolescents, excess BMI growth was linked with a higher risk of glucose dysregulation either directly or indirectly via chronic inflammation. |
Persistent Identifier | http://hdl.handle.net/10722/274113 |
ISSN | 2023 Impact Factor: 3.9 2023 SCImago Journal Rankings: 1.132 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Fong, TCT | - |
dc.date.accessioned | 2019-08-18T14:55:22Z | - |
dc.date.available | 2019-08-18T14:55:22Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Obesity Facts, 2019, v. 12 n. 3, p. 316-327 | - |
dc.identifier.issn | 1662-4025 | - |
dc.identifier.uri | http://hdl.handle.net/10722/274113 | - |
dc.description.abstract | Objective: No existing studies have examined the mediating role of chronic inflammation between obesity and dysregulated glucose homeostasis in adolescent samples. This study evaluated whether C-reactive protein (CRP), an inflammation biomarker, mediated the effects of growth (annual increase) in body mass index (BMI) on glycated hemoglobin (HbA1c). Methods: BMI and biomarker data were used from wave I to wave IV of the National Longitudinal Study of Adolescent to Adult Health (Add Health study; 4,545 adolescents; mean age = 14.9 years; 55.7% female) with valid CRP data. A causal moderated mediation analysis evaluated the direct and indirect effects of BMI slope on HbA1c via CRP across gender, with demographic and clinical characteristics as model covariates. Results: The participants displayed a linear BMI growth of 0.53–0.58 kg/m2/year throughout adolescence, with substantial interindividual variation. The BMI slope showed positive direct and indirect effects on HbA1c via CRP across gender, and there was a significant exposure-mediator interaction effect. A standardized increase in the BMI slope raised the probability of an abnormal HbA1c value by 6.0–8.5% in participants with various profiles. The total natural indirect effect accounted for 13.3–15.9% of the total effect in males and 21.2–22.7% in females. Conclusions: The findings provide support for the inflammation mechanism in the effects of adiposity on glucose homeostasis. In adolescents, excess BMI growth was linked with a higher risk of glucose dysregulation either directly or indirectly via chronic inflammation. | - |
dc.language | eng | - |
dc.publisher | Karger Publishers Open Access. The Journal's web site is located at https://www.karger.com/Journal/Home/233731 | - |
dc.relation.ispartof | Obesity Facts | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | C-reactive protein | - |
dc.subject | Childhood obesity | - |
dc.subject | Inflammation | - |
dc.subject | Moderated mediation | - |
dc.subject | Prediabetes | - |
dc.title | Indirect effects of body mass index growth on glucose dysregulation via inflammation: Causal moderated mediation analysis | - |
dc.type | Article | - |
dc.identifier.email | Fong, TCT: ttaatt@hku.hk | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1159/000500422 | - |
dc.identifier.pmid | 31132775 | - |
dc.identifier.pmcid | PMC6696889 | - |
dc.identifier.scopus | eid_2-s2.0-85067003654 | - |
dc.identifier.hkuros | 301825 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 316 | - |
dc.identifier.epage | 327 | - |
dc.identifier.isi | WOS:000476522700006 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 1662-4025 | - |