File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1111/bcpt.13295
- Scopus: eid_2-s2.0-85088412522
- PMID: 31310708
- WOS: WOS:000479513900001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Hypoxic augmentation: The tale of a strange contraction
Title | Hypoxic augmentation: The tale of a strange contraction |
---|---|
Authors | |
Keywords | 3′,5′‐cyclic inosine monophosphate endothelium‐dependent vasoconstriction hypoxia NAD(P)H:quinone oxidoreductase 1 soluble guanylyl cyclase |
Issue Date | 2020 |
Publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1742-7843/ |
Citation | Basic and Clinical Pharmacology and Toxicology, 2020, v. 127 n. 2, p. 59-66 How to Cite? |
Abstract | Almost fifty years ago, experiments on isolated veins showed that acute hypoxia augments venoconstrictor responses in vitro and that such facilitation relied on anaerobic glycolysis. Over the years, this phenomenon was extended to a number of arterial preparations of different species and revisited, from a mechanistic point of view, with the successive demonstration that it depends on calcium handling in the vascular smooth muscle cells, is endothelium‐dependent and requires the production of nitric oxide (NO) by endothelial nitric oxide synthase (eNOS) and the activation of soluble guanylyl cyclase (sGC). However, rather than the vasodilator cyclic nucleotide 3′,5′‐cyclic guanosine monophosphate (cGMP), its canonical product, the latter enzyme produces 3′,5′‐cyclic inosine monophosphate (cIMP) instead during acute hypoxia; this non‐canonical cyclic nucleotide facilitates the contractile process in the vascular smooth muscle cells. This ‘biased’ activity of soluble guanylyl cyclase appears to involve stimulation of NAD(P)H:quinone oxidoreductase 1 (NQO‐1). The exact interactions between hypoxia, anaerobic metabolism and NQO‐1 leading to biased activity of soluble guanylyl cyclase remain to be established. |
Persistent Identifier | http://hdl.handle.net/10722/273997 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.744 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vanhoutte, PM | - |
dc.contributor.author | Leung, SWS | - |
dc.date.accessioned | 2019-08-18T14:52:59Z | - |
dc.date.available | 2019-08-18T14:52:59Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Basic and Clinical Pharmacology and Toxicology, 2020, v. 127 n. 2, p. 59-66 | - |
dc.identifier.issn | 1742-7835 | - |
dc.identifier.uri | http://hdl.handle.net/10722/273997 | - |
dc.description.abstract | Almost fifty years ago, experiments on isolated veins showed that acute hypoxia augments venoconstrictor responses in vitro and that such facilitation relied on anaerobic glycolysis. Over the years, this phenomenon was extended to a number of arterial preparations of different species and revisited, from a mechanistic point of view, with the successive demonstration that it depends on calcium handling in the vascular smooth muscle cells, is endothelium‐dependent and requires the production of nitric oxide (NO) by endothelial nitric oxide synthase (eNOS) and the activation of soluble guanylyl cyclase (sGC). However, rather than the vasodilator cyclic nucleotide 3′,5′‐cyclic guanosine monophosphate (cGMP), its canonical product, the latter enzyme produces 3′,5′‐cyclic inosine monophosphate (cIMP) instead during acute hypoxia; this non‐canonical cyclic nucleotide facilitates the contractile process in the vascular smooth muscle cells. This ‘biased’ activity of soluble guanylyl cyclase appears to involve stimulation of NAD(P)H:quinone oxidoreductase 1 (NQO‐1). The exact interactions between hypoxia, anaerobic metabolism and NQO‐1 leading to biased activity of soluble guanylyl cyclase remain to be established. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1742-7843/ | - |
dc.relation.ispartof | Basic and Clinical Pharmacology and Toxicology | - |
dc.rights | Preprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | 3′,5′‐cyclic inosine monophosphate | - |
dc.subject | endothelium‐dependent vasoconstriction | - |
dc.subject | hypoxia | - |
dc.subject | NAD(P)H:quinone oxidoreductase 1 | - |
dc.subject | soluble guanylyl cyclase | - |
dc.title | Hypoxic augmentation: The tale of a strange contraction | - |
dc.type | Article | - |
dc.identifier.email | Vanhoutte, PM: vanhoutt@hku.hk | - |
dc.identifier.email | Leung, SWS: swsleung@hku.hk | - |
dc.identifier.authority | Vanhoutte, PM=rp00238 | - |
dc.identifier.authority | Leung, SWS=rp00235 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1111/bcpt.13295 | - |
dc.identifier.pmid | 31310708 | - |
dc.identifier.scopus | eid_2-s2.0-85088412522 | - |
dc.identifier.hkuros | 302378 | - |
dc.identifier.volume | 127 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 59 | - |
dc.identifier.epage | 66 | - |
dc.identifier.isi | WOS:000479513900001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1742-7835 | - |