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Article: Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study

TitleRespiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study
Authors
KeywordsAdenovirus
Cardiac complications
Influenza
Parainfluenza virus
Respiratory tract infection
Issue Date2019
PublisherElsevier Ltd. The Journal's web site is located at http://www.journals.elsevier.com/clinical-microbiology-and-infection/
Citation
Clinical Microbiology and Infection, 2019, Epub How to Cite?
AbstractObjectives: To determine the viral epidemiology and clinical characteristics of patients with and without clinically apparent respiratory tract infection. Methods: This prospective cohort study was conducted during the 2018 winter influenza season. Adult patients with fever/respiratory symptoms (fever/RS group) were age- and sex-matched with patients without fever/RS (non-fever/RS group) in a 1:1 ratio. Respiratory viruses were tested using NxTAG™ Respiratory Pathogen Panel IVD, a commercially-available multiplex PCR panel. Results: A total of 214 acutely hospitalized patients were included in the final analysis, consisting of 107 with fever/RS (fever/RS group), and 107 age- and sex-matched patients without fever/RS (non-fever/RS group). Respiratory viruses were detected in 34.1% (73/214) of patients, and co-infection occurred in 7.9% (17/214) of patients. The incidence of respiratory virus was higher in the fever/RS group than in the non-fever/RS group (44.9% (48/107) versus 23.4% (25/107), p 0.001). Influenza B virus, enterovirus/rhinovirus and coronaviruses were detected more frequently in the fever/RS group, whereas parainfluenza virus 4B and adenovirus were detected more frequently in the non-fever/RS group. Among the non-fever/RS group, chest discomfort was more common among patients tested positive for respiratory viruses than those without respiratory virus detected (44% (11/25) versus 22% (18/82), p 0.04). Conclusions: Respiratory viruses can be frequently detected among hospitalized patients without typical features of respiratory tract infection. These patients may be a source of nosocomial outbreaks. © 2019 European Society of Clinical Microbiology and Infectious Diseases
Persistent Identifierhttp://hdl.handle.net/10722/273960
ISSN
2020 Impact Factor: 8.067
2015 SCImago Journal Rankings: 2.530
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTo, KKW-
dc.contributor.authorChan, KH-
dc.contributor.authorHo, J-
dc.contributor.authorPang, PKP-
dc.contributor.authorHo, DTY-
dc.contributor.authorChang, ACH-
dc.contributor.authorSeng, CW-
dc.contributor.authorYip, CCY-
dc.contributor.authorCheng, CCV-
dc.contributor.authorHung, IFN-
dc.contributor.authorYuen, KY-
dc.date.accessioned2019-08-18T14:52:12Z-
dc.date.available2019-08-18T14:52:12Z-
dc.date.issued2019-
dc.identifier.citationClinical Microbiology and Infection, 2019, Epub-
dc.identifier.issn1198-743X-
dc.identifier.urihttp://hdl.handle.net/10722/273960-
dc.description.abstractObjectives: To determine the viral epidemiology and clinical characteristics of patients with and without clinically apparent respiratory tract infection. Methods: This prospective cohort study was conducted during the 2018 winter influenza season. Adult patients with fever/respiratory symptoms (fever/RS group) were age- and sex-matched with patients without fever/RS (non-fever/RS group) in a 1:1 ratio. Respiratory viruses were tested using NxTAG™ Respiratory Pathogen Panel IVD, a commercially-available multiplex PCR panel. Results: A total of 214 acutely hospitalized patients were included in the final analysis, consisting of 107 with fever/RS (fever/RS group), and 107 age- and sex-matched patients without fever/RS (non-fever/RS group). Respiratory viruses were detected in 34.1% (73/214) of patients, and co-infection occurred in 7.9% (17/214) of patients. The incidence of respiratory virus was higher in the fever/RS group than in the non-fever/RS group (44.9% (48/107) versus 23.4% (25/107), p 0.001). Influenza B virus, enterovirus/rhinovirus and coronaviruses were detected more frequently in the fever/RS group, whereas parainfluenza virus 4B and adenovirus were detected more frequently in the non-fever/RS group. Among the non-fever/RS group, chest discomfort was more common among patients tested positive for respiratory viruses than those without respiratory virus detected (44% (11/25) versus 22% (18/82), p 0.04). Conclusions: Respiratory viruses can be frequently detected among hospitalized patients without typical features of respiratory tract infection. These patients may be a source of nosocomial outbreaks. © 2019 European Society of Clinical Microbiology and Infectious Diseases-
dc.languageeng-
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.journals.elsevier.com/clinical-microbiology-and-infection/-
dc.relation.ispartofClinical Microbiology and Infection-
dc.subjectAdenovirus-
dc.subjectCardiac complications-
dc.subjectInfluenza-
dc.subjectParainfluenza virus-
dc.subjectRespiratory tract infection-
dc.titleRespiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study-
dc.typeArticle-
dc.identifier.emailTo, KKW: kelvinto@hku.hk-
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hk-
dc.identifier.emailCheng, CCV: vcccheng@hkucc.hku.hk-
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authorityTo, KKW=rp01384-
dc.identifier.authorityChan, KH=rp01921-
dc.identifier.authorityHung, IFN=rp00508-
dc.identifier.authorityYuen, KY=rp00366-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cmi.2019.04.012-
dc.identifier.pmid31004768-
dc.identifier.scopuseid_2-s2.0-85065922865-
dc.identifier.hkuros301134-
dc.identifier.isiWOS:000499092200017-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1198-743X-

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