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Article: Highly efficient photothermal nanoagent achieved by harvesting energy via excited-state intramolecular motion within nanoparticles

TitleHighly efficient photothermal nanoagent achieved by harvesting energy via excited-state intramolecular motion within nanoparticles
Authors
Issue Date2019
PublisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2019, v. 10 n. 1, p. article no. 768 How to Cite?
AbstractThe exciting applications of molecular motion are still limited and are in urgent pursuit, although some fascinating concepts such as molecular motors and molecular machines have been proposed for years. Utilizing molecular motion in a nanoplatform for practical application has been scarcely explored due to some unconquered challenges such as how to achieve effective molecular motion in the aggregate state within nanoparticles. Here, we introduce a class of near infrared-absorbing organic molecules with intramolecular motion-induced photothermy inside nanoparticles, which enables most absorbed light energy to dissipate as heat. Such a property makes the nanoparticles a superior photoacoustic imaging agent compared to widely used methylene blue and semiconducting polymer nanoparticles and allow them for high-contrast photoacoustic imaging of tumours in live mice. This study not only provides a strategy for developing advanced photothermal/photoacoustic imaging nanoagents, but also enables molecular motion in a nanoplatform to find a way for practical application.
Persistent Identifierhttp://hdl.handle.net/10722/273836
ISSN
2020 Impact Factor: 14.919
2015 SCImago Journal Rankings: 6.539
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhao, Z-
dc.contributor.authorChen, C-
dc.contributor.authorWu, WT-
dc.contributor.authorWang, FF-
dc.contributor.authorDu, L-
dc.contributor.authorZhang, XY-
dc.contributor.authorXiong, Y-
dc.contributor.authorHe, XW-
dc.contributor.authorCai, YJ-
dc.contributor.authorKwok, RTK-
dc.contributor.authorLam, JWY-
dc.contributor.authorGao, XK-
dc.contributor.authorSun, PC-
dc.contributor.authorPhillips, DL-
dc.contributor.authorDing, D-
dc.contributor.authorTang, BZ-
dc.date.accessioned2019-08-18T14:49:32Z-
dc.date.available2019-08-18T14:49:32Z-
dc.date.issued2019-
dc.identifier.citationNature Communications, 2019, v. 10 n. 1, p. article no. 768-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/273836-
dc.description.abstractThe exciting applications of molecular motion are still limited and are in urgent pursuit, although some fascinating concepts such as molecular motors and molecular machines have been proposed for years. Utilizing molecular motion in a nanoplatform for practical application has been scarcely explored due to some unconquered challenges such as how to achieve effective molecular motion in the aggregate state within nanoparticles. Here, we introduce a class of near infrared-absorbing organic molecules with intramolecular motion-induced photothermy inside nanoparticles, which enables most absorbed light energy to dissipate as heat. Such a property makes the nanoparticles a superior photoacoustic imaging agent compared to widely used methylene blue and semiconducting polymer nanoparticles and allow them for high-contrast photoacoustic imaging of tumours in live mice. This study not only provides a strategy for developing advanced photothermal/photoacoustic imaging nanoagents, but also enables molecular motion in a nanoplatform to find a way for practical application.-
dc.languageeng-
dc.publisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleHighly efficient photothermal nanoagent achieved by harvesting energy via excited-state intramolecular motion within nanoparticles-
dc.typeArticle-
dc.identifier.emailDu, L: ailleen@hku.hk-
dc.identifier.emailPhillips, DL: phillips@hku.hk-
dc.identifier.authorityPhillips, DL=rp00770-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41467-019-08722-z-
dc.identifier.pmid30770816-
dc.identifier.scopuseid_2-s2.0-85061596165-
dc.identifier.hkuros300968-
dc.identifier.volume10-
dc.identifier.issue1-
dc.identifier.spagearticle no. 768-
dc.identifier.epagearticle no. 768-
dc.identifier.isiWOS:000458754700011-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl2041-1723-

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