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Conference Paper: Postnatal refinement of circuit plasticity for spatial navigation

TitlePostnatal refinement of circuit plasticity for spatial navigation
Authors
Issue Date2019
PublisherSpringer. The Journal's web site is located at https://link.springer.com/journal/12576
Citation
Proceedings of the 9th Federation of the Asian and Oceanian Physiological Society Congress (FAOPS2019) in conjunction with the 96th Annual Meeting of The Physiological Society of Japan: Philosophy of Life: Function and Mechanisms, Kobe, Japan, 28-31 March 2019. In Journal of Physiological Sciences, 2019, v. 69 n. Suppl. 1, p. S16, abstract no. S7-3 How to Cite?
AbstractThe formation and consolidation of neural networks for a specific function are dependent on maturation of synaptic elements in the circuit. We hypothesize that synaptic efficacy of vestibular neurons undergoes postnatal tuning to sharpen spatial coding for the presentation of relevant behaviors. Whole-cell patch-clamp data from the vestibular nucleus (VN) of neonatal rodents indicated that endocannabinoid, serotonin and orexin could tune the efficacy of GABA transmission. The impact of such neuromodulators on postnatal emergence of vestibular- dependent graviceptive reflex was revealed using specific agonist/antagonist delivered to the neonatal VN; the deficits in spatial cognition so caused lasted well into adulthood. However, similar perturbations in juvenile animals posed no effect. To study whether the observed effects were due to perturbation of GABA circuits, we directly attenuated GABA transmission in the neonatal VN and found similar behavioral deficits. Optogenetic activation of inhibitory VN interneurons in these animals revealed permanent reorganization of inhibitory input to projection neurons. We reason that this underlies derangement of spatial maps in the forebrain of the experimental animals with spatial cognition deficits. Altogether, we show that neuro modulators tune GABA transmission and are instrumental in developmental consolidation of the vestibular circuitry for spatial recognition.
DescriptionSymposium7 (S7) From synaptic and network plasticity to behavior - no. S7-3
Persistent Identifierhttp://hdl.handle.net/10722/272767
ISSN
2020 Impact Factor: 2.781
2020 SCImago Journal Rankings: 0.968

 

DC FieldValueLanguage
dc.contributor.authorChan, YS-
dc.contributor.authorWu, LK-
dc.contributor.authorShi, W-
dc.contributor.authorJiang, Q-
dc.contributor.authorMa, CW-
dc.contributor.authorShum, DKY-
dc.date.accessioned2019-08-06T09:16:11Z-
dc.date.available2019-08-06T09:16:11Z-
dc.date.issued2019-
dc.identifier.citationProceedings of the 9th Federation of the Asian and Oceanian Physiological Society Congress (FAOPS2019) in conjunction with the 96th Annual Meeting of The Physiological Society of Japan: Philosophy of Life: Function and Mechanisms, Kobe, Japan, 28-31 March 2019. In Journal of Physiological Sciences, 2019, v. 69 n. Suppl. 1, p. S16, abstract no. S7-3-
dc.identifier.issn1880-6546-
dc.identifier.urihttp://hdl.handle.net/10722/272767-
dc.descriptionSymposium7 (S7) From synaptic and network plasticity to behavior - no. S7-3-
dc.description.abstractThe formation and consolidation of neural networks for a specific function are dependent on maturation of synaptic elements in the circuit. We hypothesize that synaptic efficacy of vestibular neurons undergoes postnatal tuning to sharpen spatial coding for the presentation of relevant behaviors. Whole-cell patch-clamp data from the vestibular nucleus (VN) of neonatal rodents indicated that endocannabinoid, serotonin and orexin could tune the efficacy of GABA transmission. The impact of such neuromodulators on postnatal emergence of vestibular- dependent graviceptive reflex was revealed using specific agonist/antagonist delivered to the neonatal VN; the deficits in spatial cognition so caused lasted well into adulthood. However, similar perturbations in juvenile animals posed no effect. To study whether the observed effects were due to perturbation of GABA circuits, we directly attenuated GABA transmission in the neonatal VN and found similar behavioral deficits. Optogenetic activation of inhibitory VN interneurons in these animals revealed permanent reorganization of inhibitory input to projection neurons. We reason that this underlies derangement of spatial maps in the forebrain of the experimental animals with spatial cognition deficits. Altogether, we show that neuro modulators tune GABA transmission and are instrumental in developmental consolidation of the vestibular circuitry for spatial recognition.-
dc.languageeng-
dc.publisherSpringer. The Journal's web site is located at https://link.springer.com/journal/12576-
dc.relation.ispartof9th Federation of the Asian and Oceanian Physiological Society Congress (FAOPS2019)-
dc.relation.ispartofJournal of Physiological Sciences-
dc.titlePostnatal refinement of circuit plasticity for spatial navigation-
dc.typeConference_Paper-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.emailWu, LK: lwu03@hku.hk-
dc.identifier.emailMa, CW: cwma2010@hku.hk-
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hk-
dc.identifier.authorityChan, YS=rp00318-
dc.identifier.authorityShum, DKY=rp00321-
dc.identifier.hkuros300597-
dc.identifier.volume69-
dc.identifier.issueSuppl. 1-
dc.identifier.spageS16-
dc.identifier.epageS16-
dc.publisher.placeJapan-
dc.identifier.issnl1880-6546-

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