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Article: The Paradoxical Effect of Deep Brain Stimulation on Memory

TitleThe Paradoxical Effect of Deep Brain Stimulation on Memory
Authors
Keywordsmemory
neuromodulation
deep brain stimulation
dementia
anxiety
Issue Date2020
PublisherBuck Institute for Age Research. The Journal's web site is located at http://www.aginganddisease.org
Citation
Aging and Disease, 2020, v. 11 n. 1, p. 179-190 How to Cite?
AbstractDeep brain stimulation (DBS) is a promising treatment for many memory-related disorders including dementia, anxiety, and addiction. However, the use of DBS can be a paradoxical conundrum—dementia treatments aim to improve memory, whereas anxiety or addiction treatments aim to suppress maladaptive memory. In this review, the key hypotheses on how DBS affects memory are highlighted. We consolidate the findings and conclusions from the current research on the effects of DBS on memory in attempt to make sense of the bidirectional nature of DBS in disrupting and enhancing memory. Based on the current literature, we hypothesize that the timing of DBS plays a key role in its contradictory effects, and therefore, we propose a consolidated model of how DBS can both disrupt and enhance memory.
Persistent Identifierhttp://hdl.handle.net/10722/272730
ISSN
2023 Impact Factor: 7.0
2023 SCImago Journal Rankings: 1.922
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTan, SZK-
dc.contributor.authorFung, ML-
dc.contributor.authorKoh, J-
dc.contributor.authorChan, YS-
dc.contributor.authorLim, LW-
dc.date.accessioned2019-08-06T09:15:28Z-
dc.date.available2019-08-06T09:15:28Z-
dc.date.issued2020-
dc.identifier.citationAging and Disease, 2020, v. 11 n. 1, p. 179-190-
dc.identifier.issn2152-5250-
dc.identifier.urihttp://hdl.handle.net/10722/272730-
dc.description.abstractDeep brain stimulation (DBS) is a promising treatment for many memory-related disorders including dementia, anxiety, and addiction. However, the use of DBS can be a paradoxical conundrum—dementia treatments aim to improve memory, whereas anxiety or addiction treatments aim to suppress maladaptive memory. In this review, the key hypotheses on how DBS affects memory are highlighted. We consolidate the findings and conclusions from the current research on the effects of DBS on memory in attempt to make sense of the bidirectional nature of DBS in disrupting and enhancing memory. Based on the current literature, we hypothesize that the timing of DBS plays a key role in its contradictory effects, and therefore, we propose a consolidated model of how DBS can both disrupt and enhance memory.-
dc.languageeng-
dc.publisherBuck Institute for Age Research. The Journal's web site is located at http://www.aginganddisease.org-
dc.relation.ispartofAging and Disease-
dc.subjectmemory-
dc.subjectneuromodulation-
dc.subjectdeep brain stimulation-
dc.subjectdementia-
dc.subjectanxiety-
dc.titleThe Paradoxical Effect of Deep Brain Stimulation on Memory-
dc.typeArticle-
dc.identifier.emailFung, M-L: fungml@hku.hk-
dc.identifier.emailKoh, J: kohjh@HKUCC-COM.hku.hk-
dc.identifier.emailChan, Y-S: yschan@hku.hk-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.authorityFung, M-L=rp00433-
dc.identifier.authorityChan, Y-S=rp00318-
dc.identifier.authorityLim, LW=rp02088-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.14336/AD.2019.0511-
dc.identifier.scopuseid_2-s2.0-85078230419-
dc.identifier.hkuros300765-
dc.identifier.hkuros309360-
dc.identifier.hkuros316104-
dc.identifier.volume11-
dc.identifier.issue1-
dc.identifier.spage179-
dc.identifier.epage190-
dc.identifier.isiWOS:000507513900015-
dc.publisher.placeUnited States-
dc.identifier.issnl2152-5250-

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