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Article: Role of Tear Film Biomarkers in the Diagnosis and Management of Dry Eye Disease
Title | Role of Tear Film Biomarkers in the Diagnosis and Management of Dry Eye Disease |
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Authors | |
Keywords | Diagnosis Dry eye disease Inflammation Systematic review Tear film biomarkers |
Issue Date | 2019 |
Publisher | Wolters Kluwer - Medknow Publications and Media Pvt. Ltd.. The Journal's web site is located at http://www.e-tjo.org |
Citation | Taiwan Journal of Ophthalmology, 2019, v. 9 n. 3, p. 150-159 How to Cite? |
Abstract | In recent years, there has been increasing scientific interest in the use of tear film biomarkers in the diagnosis and management of dry eye disease, owning to their potential important roles in the pathogenesis of ocular surface damage, as well as the technical feasibility of tear sample collection techniques. An Entrez Pubmed search was conducted on the 2nd of March 2019 to include papers investigating the use of tear film biomarkers in DED, and results were classified according to whether the DED is associated with systemic inflammatory disease or not, and further classified within each section according to the molecular nature of the biomarker for further discussion. A total of 58 relevant articles were reviewed. Certain cytokines, including IL-6, TNF-α, IL-17, IL-8 were found by a number of studies to consistently reflect disease severity well and had strong correlations with tear film metrics and tests for ocular surface damage in dry eye without systemic inflammatory disease. For dry eye with systemic inflammatory disease, IL-17, IL-8, IL-1RA were shown to be consistently higher in affected eyes and correlated well with ocular surface disease severity in more than one type of inflammatory disease. With the advancement in technology and lowered costs in the future, tear film biomarker counts would allow better diagnosis and monitoring of dry eye disease, as well as facilitate personalized treatment strategies. |
Persistent Identifier | http://hdl.handle.net/10722/272723 |
ISSN | 2023 Impact Factor: 1.0 2023 SCImago Journal Rankings: 0.420 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Fong, PY | - |
dc.contributor.author | Shih, KC | - |
dc.contributor.author | Lam, PY | - |
dc.contributor.author | Chan, TCY | - |
dc.contributor.author | Jhanji, V | - |
dc.contributor.author | Tong, L | - |
dc.date.accessioned | 2019-08-06T09:15:21Z | - |
dc.date.available | 2019-08-06T09:15:21Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Taiwan Journal of Ophthalmology, 2019, v. 9 n. 3, p. 150-159 | - |
dc.identifier.issn | 2211-5056 | - |
dc.identifier.uri | http://hdl.handle.net/10722/272723 | - |
dc.description.abstract | In recent years, there has been increasing scientific interest in the use of tear film biomarkers in the diagnosis and management of dry eye disease, owning to their potential important roles in the pathogenesis of ocular surface damage, as well as the technical feasibility of tear sample collection techniques. An Entrez Pubmed search was conducted on the 2nd of March 2019 to include papers investigating the use of tear film biomarkers in DED, and results were classified according to whether the DED is associated with systemic inflammatory disease or not, and further classified within each section according to the molecular nature of the biomarker for further discussion. A total of 58 relevant articles were reviewed. Certain cytokines, including IL-6, TNF-α, IL-17, IL-8 were found by a number of studies to consistently reflect disease severity well and had strong correlations with tear film metrics and tests for ocular surface damage in dry eye without systemic inflammatory disease. For dry eye with systemic inflammatory disease, IL-17, IL-8, IL-1RA were shown to be consistently higher in affected eyes and correlated well with ocular surface disease severity in more than one type of inflammatory disease. With the advancement in technology and lowered costs in the future, tear film biomarker counts would allow better diagnosis and monitoring of dry eye disease, as well as facilitate personalized treatment strategies. | - |
dc.language | eng | - |
dc.publisher | Wolters Kluwer - Medknow Publications and Media Pvt. Ltd.. The Journal's web site is located at http://www.e-tjo.org | - |
dc.relation.ispartof | Taiwan Journal of Ophthalmology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Diagnosis | - |
dc.subject | Dry eye disease | - |
dc.subject | Inflammation | - |
dc.subject | Systematic review | - |
dc.subject | Tear film biomarkers | - |
dc.title | Role of Tear Film Biomarkers in the Diagnosis and Management of Dry Eye Disease | - |
dc.type | Article | - |
dc.identifier.email | Shih, KC: kcshih@hku.hk | - |
dc.identifier.authority | Shih, KC=rp01374 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.4103/tjo.tjo_56_19 | - |
dc.identifier.scopus | eid_2-s2.0-85072389194 | - |
dc.identifier.hkuros | 300018 | - |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 150 | - |
dc.identifier.epage | 159 | - |
dc.identifier.isi | WOS:000572108300003 | - |
dc.publisher.place | India | - |
dc.identifier.issnl | 2211-5056 | - |