File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Survival differences in multiple myeloma in Latin America and Asia: a comparison involving 3664 patients from regional registries

TitleSurvival differences in multiple myeloma in Latin America and Asia: a comparison involving 3664 patients from regional registries
Authors
KeywordsMultiple myeloma
Survival analysis
Latin America and Asia
Issue Date2019
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htm
Citation
Annals of Hematology, 2019, v. 98 n. 4, p. 941-949 How to Cite?
AbstractIn previous observational studies, we have separately characterized patients with multiple myeloma (MM) both from Latin America (LA) and from Asia. Here, we analyze these two datasets jointly, in order to assess the overall survival (OS) in these two world regions. Data were available from 3664 patients (1968 from LA and 1696 from Asia); all of whom diagnosed between 1998 and 2007. Approximately, 26% of patients in both world regions underwent transplantation. OS (from diagnosis of MM) was explored with Kaplan–Meier analyses and Cox proportional hazards models. Patients from LA were significantly younger and had hypercalcemia more often than Asian patients, who in turn had higher proportions of anemia and International Staging System (ISS) stage III disease. The median OS was 56 months in LA, and 47 months in Asia (hazard ratio [HR] = 0.83; 95% confidence interval [CI], 0.76 to 0.91; P < 0.001). In multivariable analysis, age, ISS stage III, anemia, hypercalcemia, and world region remained significantly associated with OS (P < 0.001 for all covariates). These results were largely driven by patients not undergoing transplantation, as no difference in OS emerged between the two world regions in univariable or multivariable analysis for transplanted patients. Despite adverse prognostic features differentially favoring each region, and adjusting for such differences, we found an OS advantage for patients from LA, in comparison with contemporaneous patients from Asia. Whether this is due to different biological features, differences in access to novel agents (especially thalidomide in earlier periods of the study), unmeasured confounders, or the play of chance, remain unknown.
Persistent Identifierhttp://hdl.handle.net/10722/272289
ISSN
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 0.912
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHungria, VTM-
dc.contributor.authorLee, JH-
dc.contributor.authorMaiolino, A-
dc.contributor.authorde Queiroz Crusoe, E-
dc.contributor.authorMartinez, G-
dc.contributor.authorBittencourt, R-
dc.contributor.authorDuarte, GO-
dc.contributor.authorFantl, DB-
dc.contributor.authorNavarro, JR-
dc.contributor.authorConte, G-
dc.contributor.authorGomez-Almaguer, D-
dc.contributor.authorRuiz-Argüelles, GJ-
dc.contributor.authorKim, K-
dc.contributor.authorShimizu, K-
dc.contributor.authorChen, W-
dc.contributor.authorHuang, SY-
dc.contributor.authorChng, WJ-
dc.contributor.authorChim, CS-
dc.contributor.authorNawarawong, W-
dc.contributor.authorDurie, B-
dc.date.accessioned2019-07-20T10:39:21Z-
dc.date.available2019-07-20T10:39:21Z-
dc.date.issued2019-
dc.identifier.citationAnnals of Hematology, 2019, v. 98 n. 4, p. 941-949-
dc.identifier.issn0939-5555-
dc.identifier.urihttp://hdl.handle.net/10722/272289-
dc.description.abstractIn previous observational studies, we have separately characterized patients with multiple myeloma (MM) both from Latin America (LA) and from Asia. Here, we analyze these two datasets jointly, in order to assess the overall survival (OS) in these two world regions. Data were available from 3664 patients (1968 from LA and 1696 from Asia); all of whom diagnosed between 1998 and 2007. Approximately, 26% of patients in both world regions underwent transplantation. OS (from diagnosis of MM) was explored with Kaplan–Meier analyses and Cox proportional hazards models. Patients from LA were significantly younger and had hypercalcemia more often than Asian patients, who in turn had higher proportions of anemia and International Staging System (ISS) stage III disease. The median OS was 56 months in LA, and 47 months in Asia (hazard ratio [HR] = 0.83; 95% confidence interval [CI], 0.76 to 0.91; P < 0.001). In multivariable analysis, age, ISS stage III, anemia, hypercalcemia, and world region remained significantly associated with OS (P < 0.001 for all covariates). These results were largely driven by patients not undergoing transplantation, as no difference in OS emerged between the two world regions in univariable or multivariable analysis for transplanted patients. Despite adverse prognostic features differentially favoring each region, and adjusting for such differences, we found an OS advantage for patients from LA, in comparison with contemporaneous patients from Asia. Whether this is due to different biological features, differences in access to novel agents (especially thalidomide in earlier periods of the study), unmeasured confounders, or the play of chance, remain unknown.-
dc.languageeng-
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htm-
dc.relation.ispartofAnnals of Hematology-
dc.subjectMultiple myeloma-
dc.subjectSurvival analysis-
dc.subjectLatin America and Asia-
dc.titleSurvival differences in multiple myeloma in Latin America and Asia: a comparison involving 3664 patients from regional registries-
dc.typeArticle-
dc.identifier.emailChim, CS: jcschim@hku.hk-
dc.identifier.authorityChim, CS=rp00408-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00277-019-03602-4-
dc.identifier.pmid30729281-
dc.identifier.scopuseid_2-s2.0-85061178671-
dc.identifier.hkuros299541-
dc.identifier.volume98-
dc.identifier.issue4-
dc.identifier.spage941-
dc.identifier.epage949-
dc.identifier.isiWOS:000461545800015-
dc.publisher.placeGermany-
dc.identifier.issnl0939-5555-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats