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Conference Paper: A Randomized Controlled Trial to Arrest Dentine Caries: 12-month Result
Title | A Randomized Controlled Trial to Arrest Dentine Caries: 12-month Result |
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Authors | |
Issue Date | 2019 |
Publisher | International Association for Dental Research. |
Citation | The 97th General Session of the International Association of Dental Research (IADR) held with the 48th Annual Meeting of the American Association for Dental Research (AADR) & the 43rd Annual Meeting of the Canadian Association for Dental Research (CADR), Vancouver, BC, Canada, 19-22 June 2019. In Journal of Dental Research, 2019, v. 98 n. Spec ISS A, p. S0598 How to Cite? |
Abstract | Objectives: The objective of this study is to compare the effectiveness of two topical fluoride application protocols in arresting coronal dentine caries of primary teeth among preschool children.
Methods: This is a double-blind, two-arm, parallel-design randomized controlled trial. Children aged 3-4 years old who had at least one coronal dentine carious lesion were randomly allocated into two groups: Group A received semi-annual application of a 25% silver nitrate (AgNO3) solution followed by a 5% sodium fluoride (NaF) varnish; and Group B received semi-annual application of a 25% AgNO3 solution followed by a 5% NaF varnish with functionalized tricalcium phosphate (fTCP). One examiner performed oral examinations every six months to assess whether the treated lesions had been arrested. Chi-square test, intention-to-treat analysis and multilevel logistic regression analysis were undertaken.
Results: Four hundred and eight children (48.5% boy) with 1,833 active carious tooth surfaces were recruited at baseline. No statistically significant differences were found between groups regarding the background, oral health-related behaviours, oral hygiene status and baseline caries status. After 12 months, 402 (98.5%) children remained in the study. The caries arrest rates at surface level were 45% and 52% for Group A and Group B, respectively (p<0.001). Results of the multilevel logistic regression showed protocol of Group B (AgNO3 plus NaF with fTCP) had a higher chance to arrest active dentine caries (OR=1.50, p=0.009). Carious lesions on buccal/palatal surfaces, in anterior teeth and in children who brushed at least twice daily had higher chance to be arrested (OR=2.56, 1.47 and 1.58 respectively, p<0.05).
Conclusions: Semi-annual application of a 25% AgNO3 solution followed by a 5% NaF varnish with fTCP is more effective in arresting dentine caries in primary teeth than the semi-annual application of a 25% AgNO3 solution followed by a 5% NaF varnish. |
Description | Poster Session - 115 - Cariology Research: Clinical Studies - Poster Presentation no. 0538 |
Persistent Identifier | http://hdl.handle.net/10722/272027 |
DC Field | Value | Language |
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dc.contributor.author | Chen, KJY | - |
dc.contributor.author | Gao, SS | - |
dc.contributor.author | Duangthip, D | - |
dc.contributor.author | Lo, ECM | - |
dc.contributor.author | Chu, CH | - |
dc.date.accessioned | 2019-07-20T10:34:14Z | - |
dc.date.available | 2019-07-20T10:34:14Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | The 97th General Session of the International Association of Dental Research (IADR) held with the 48th Annual Meeting of the American Association for Dental Research (AADR) & the 43rd Annual Meeting of the Canadian Association for Dental Research (CADR), Vancouver, BC, Canada, 19-22 June 2019. In Journal of Dental Research, 2019, v. 98 n. Spec ISS A, p. S0598 | - |
dc.identifier.uri | http://hdl.handle.net/10722/272027 | - |
dc.description | Poster Session - 115 - Cariology Research: Clinical Studies - Poster Presentation no. 0538 | - |
dc.description.abstract | Objectives: The objective of this study is to compare the effectiveness of two topical fluoride application protocols in arresting coronal dentine caries of primary teeth among preschool children. Methods: This is a double-blind, two-arm, parallel-design randomized controlled trial. Children aged 3-4 years old who had at least one coronal dentine carious lesion were randomly allocated into two groups: Group A received semi-annual application of a 25% silver nitrate (AgNO3) solution followed by a 5% sodium fluoride (NaF) varnish; and Group B received semi-annual application of a 25% AgNO3 solution followed by a 5% NaF varnish with functionalized tricalcium phosphate (fTCP). One examiner performed oral examinations every six months to assess whether the treated lesions had been arrested. Chi-square test, intention-to-treat analysis and multilevel logistic regression analysis were undertaken. Results: Four hundred and eight children (48.5% boy) with 1,833 active carious tooth surfaces were recruited at baseline. No statistically significant differences were found between groups regarding the background, oral health-related behaviours, oral hygiene status and baseline caries status. After 12 months, 402 (98.5%) children remained in the study. The caries arrest rates at surface level were 45% and 52% for Group A and Group B, respectively (p<0.001). Results of the multilevel logistic regression showed protocol of Group B (AgNO3 plus NaF with fTCP) had a higher chance to arrest active dentine caries (OR=1.50, p=0.009). Carious lesions on buccal/palatal surfaces, in anterior teeth and in children who brushed at least twice daily had higher chance to be arrested (OR=2.56, 1.47 and 1.58 respectively, p<0.05). Conclusions: Semi-annual application of a 25% AgNO3 solution followed by a 5% NaF varnish with fTCP is more effective in arresting dentine caries in primary teeth than the semi-annual application of a 25% AgNO3 solution followed by a 5% NaF varnish. | - |
dc.language | eng | - |
dc.publisher | International Association for Dental Research. | - |
dc.relation.ispartof | IADR/AADR/CADR 2019 General Session & Exhibition | - |
dc.relation.ispartof | Journal of Dental Research (Spec Issue) | - |
dc.title | A Randomized Controlled Trial to Arrest Dentine Caries: 12-month Result | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Duangthip, D: dduang@hku.hk | - |
dc.identifier.email | Lo, ECM: edward-lo@hku.hk | - |
dc.identifier.email | Chu, CH: chchu@hku.hk | - |
dc.identifier.authority | Duangthip, D=rp02457 | - |
dc.identifier.authority | Lo, ECM=rp00015 | - |
dc.identifier.authority | Chu, CH=rp00022 | - |
dc.identifier.hkuros | 298799 | - |
dc.identifier.volume | 98 | - |
dc.identifier.issue | Spec ISS A | - |
dc.identifier.spage | S0598 | - |
dc.identifier.epage | S0598 | - |
dc.publisher.place | United States | - |