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Article: A black phosphorus/manganese dioxide nanoplatform: Oxygen self-supply monitoring, photodynamic therapy enhancement and feedback

TitleA black phosphorus/manganese dioxide nanoplatform: Oxygen self-supply monitoring, photodynamic therapy enhancement and feedback
Authors
KeywordsBiosensors
Black phosphorus
Manganese dioxide
Fluorescent probes
Photodynamic therapy
Oxygen self-supply
Issue Date2019
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation
Biomaterials, 2019, v. 192, p. 179-188 How to Cite?
AbstractSelecting the timing of laser treatment is an important task for improving O2-dependent photodynamic therapy (PDT) efficiency. Here, a black phosphorus-based strategy was developed for dual-mode monitoring oxygen self-supply, enhancing photodynamic therapy, and feeding back therapeutic effect. The hybridized nanoplatform (R-MnO2-FBP) was prepared by assembly of Rhodamine B (RhB)-encapsulated manganese dioxide (R-MnO2) as O2 supplier and indicator, and fluorescein isothiocyanate (FITC)-labelled peptide-functionalized black phosphorus as the theranostic agent. The time-dependent assays suggested that the O2 release was proportional to the liberation of Mn2+ and RhB in the R-MnO2-FBP system. After specific delivery into cancer cells, R-MnO2-FBP was dissociated in the acidic and H2O2-rich environment and generated oxygen to overcome hypoxia-associated PDT resistance. In the meantime, it released both Mn2+and RhB dye, leading to dual-mode (magnetic resonance imaging/fluorescence imaging) monitoring of the oxygen self-supply process. More significantly, the imaging-guided PDT in hypoxic cells displayed 51.6% of cell apoptosis at optimizing timing of laser application, which could also be confirmed by the FITC fluorescence recovery induced by the activated caspase-3 in apoptotic cells. In vivo photonic therapy by R-MnO2-FBP further demonstrated the ability of R-MnO2-FBP to choose the timing of laser application, providing an efficient approach for the enhancement of PDT process.
Persistent Identifierhttp://hdl.handle.net/10722/271935
ISSN
2019 Impact Factor: 10.317
2015 SCImago Journal Rankings: 3.565
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, J-
dc.contributor.authorDu, P-
dc.contributor.authorLiu, T-
dc.contributor.authorWong, BJC-
dc.contributor.authorWang, W-
dc.contributor.authorJu, H-
dc.contributor.authorLei, J-
dc.date.accessioned2019-07-20T10:32:24Z-
dc.date.available2019-07-20T10:32:24Z-
dc.date.issued2019-
dc.identifier.citationBiomaterials, 2019, v. 192, p. 179-188-
dc.identifier.issn0142-9612-
dc.identifier.urihttp://hdl.handle.net/10722/271935-
dc.description.abstractSelecting the timing of laser treatment is an important task for improving O2-dependent photodynamic therapy (PDT) efficiency. Here, a black phosphorus-based strategy was developed for dual-mode monitoring oxygen self-supply, enhancing photodynamic therapy, and feeding back therapeutic effect. The hybridized nanoplatform (R-MnO2-FBP) was prepared by assembly of Rhodamine B (RhB)-encapsulated manganese dioxide (R-MnO2) as O2 supplier and indicator, and fluorescein isothiocyanate (FITC)-labelled peptide-functionalized black phosphorus as the theranostic agent. The time-dependent assays suggested that the O2 release was proportional to the liberation of Mn2+ and RhB in the R-MnO2-FBP system. After specific delivery into cancer cells, R-MnO2-FBP was dissociated in the acidic and H2O2-rich environment and generated oxygen to overcome hypoxia-associated PDT resistance. In the meantime, it released both Mn2+and RhB dye, leading to dual-mode (magnetic resonance imaging/fluorescence imaging) monitoring of the oxygen self-supply process. More significantly, the imaging-guided PDT in hypoxic cells displayed 51.6% of cell apoptosis at optimizing timing of laser application, which could also be confirmed by the FITC fluorescence recovery induced by the activated caspase-3 in apoptotic cells. In vivo photonic therapy by R-MnO2-FBP further demonstrated the ability of R-MnO2-FBP to choose the timing of laser application, providing an efficient approach for the enhancement of PDT process.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials-
dc.relation.ispartofBiomaterials-
dc.subjectBiosensors-
dc.subjectBlack phosphorus-
dc.subjectManganese dioxide-
dc.subjectFluorescent probes-
dc.subjectPhotodynamic therapy-
dc.subjectOxygen self-supply-
dc.titleA black phosphorus/manganese dioxide nanoplatform: Oxygen self-supply monitoring, photodynamic therapy enhancement and feedback-
dc.typeArticle-
dc.identifier.emailWang, W: wangwp@hku.hk-
dc.identifier.authorityWang, W=rp02227-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biomaterials.2018.10.018-
dc.identifier.pmid30453214-
dc.identifier.scopuseid_2-s2.0-85057154053-
dc.identifier.hkuros298810-
dc.identifier.volume192-
dc.identifier.spage179-
dc.identifier.epage188-
dc.identifier.isiWOS:000456902000015-
dc.publisher.placeNetherlands-

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